Article ; Online: COVID-19 pneumonia: relationship between inflammation assessed by whole-body FDG PET/CT and short-term clinical outcome.
European journal of nuclear medicine and molecular imaging
2020 Volume 48, Issue 1, Page(s) 260–268
Abstract: ... CT data were compared with chest CT evolution and short-term clinical outcome. All inflammatory sites ... peak of the inflammatory phase in COVID-19 patients is obvious in FDG PET/CT scans. Glucose uptake is ... chest CT evolution or short-term clinical outcome.: Conclusion: Inflammatory process at the presumed ...
| Abstract | Purpose: [18F]-2-Fluoro-2-deoxy-D-glucose PET/CT (FDG PET/CT) is a sensitive and quantitative technic for detecting inflammatory process. Glucose uptake is correlated with an increased anaerobic glycolysis seen in activated inflammatory cells such as monocytes, lymphocytes, and granulocytes. The aim of the study was to assess the inflammatory status at the presumed peak of the inflammatory phase in non-critically ill patients requiring admission for COVID-19. Methods: Patients admitted with COVID-19 were prospectively enrolled. FDG PET/CT was performed from day 6 to day 14 of the onset of symptoms. Depending on FDG PET/CT findings, patients' profiles were classified as "inflammatory" or "low inflammatory." FDG PET/CT data were compared with chest CT evolution and short-term clinical outcome. All inflammatory sites were reported to screen potential extra-pulmonary tropism. Results: Thirteen patients were included. Maximum standardized uptake values ranged from 4.7 to 16.3 in lungs. All patients demonstrated increased mediastinal lymph nodes glucose uptake. Three patients (23%) presented mild nasopharyngeal, two patients (15%) bone marrow, and five patients (38%) splenic mild increase in glucose uptake. No patient had significant digestive focal or segmental glucose uptake. There was no significant physiological myocardial glucose uptake in all patients except one. There was no correlation between PET lung inflammatory status and chest CT evolution or short-term clinical outcome. Conclusion: Inflammatory process at the presumed peak of the inflammatory phase in COVID-19 patients is obvious in FDG PET/CT scans. Glucose uptake is heterogeneous and typically focused on lungs. Trial registration: NCT04441489. Registered 22 June 2020 (retrospectively registered). |
|---|---|
| MeSH term(s) | Aged ; Aged, 80 and over ; COVID-19/classification ; COVID-19/diagnostic imaging ; COVID-19/therapy ; Female ; Fluorodeoxyglucose F18 ; Heart/diagnostic imaging ; Humans ; Inflammation/diagnostic imaging ; Lung/diagnostic imaging ; Lymph Nodes/diagnostic imaging ; Male ; Middle Aged ; Positron Emission Tomography Computed Tomography ; Radiopharmaceuticals ; Treatment Outcome |
| Chemical Substances | Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-07-25 |
| Publishing country | Germany |
| Document type | Clinical Trial ; Journal Article |
| ZDB-ID | 8236-3 |
| ISSN | 1619-7089 ; 0340-6997 ; 1619-7070 |
| ISSN (online) | 1619-7089 |
| ISSN | 0340-6997 ; 1619-7070 |
| DOI | 10.1007/s00259-020-04968-8 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 1227: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.