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  1. Article ; Online: Emerging New Concepts of Degrader Technologies.

    Ding, Yu / Fei, Yiyan / Lu, Boxun

    Trends in pharmacological sciences

    2020  Volume 41, Issue 7, Page(s) 464–474

    Abstract: ... degrader technologies may greatly broaden the spectrum of targets that could be selectively degraded ... a promising approach for drug discovery. However, the PROTAC technology has some limitations, and emerging new ... by harnessing a second major degradation pathway in cells. We review key emerging technologies that exploit ...

    Abstract Traditional drug discovery focuses on identifying direct inhibitors of target proteins. This typically relies on a measurable biochemical readout and accessible binding sites whose occupancy influences the function of the target protein. These requirements preclude many disease-causing proteins from being 'druggable' targets, and these proteins are categorized as 'undruggable'. The proteolysis-targeting chimera (PROTAC) technology provides powerful tools to degrade these undruggable targets and has become a promising approach for drug discovery. However, the PROTAC technology has some limitations, and emerging new degrader technologies may greatly broaden the spectrum of targets that could be selectively degraded by harnessing a second major degradation pathway in cells. We review key emerging technologies that exploit the lysosomal degradation pathway and discuss their potential applications and limitations.
    MeSH term(s) Drug Discovery ; Humans ; Proteins/metabolism ; Proteolysis ; Technology
    Chemical Substances Proteins
    Keywords covid19
    Language English
    Publishing date 2020-04-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2020.04.005
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  2. Article ; Online: Emerging New Concepts of Degrader Technologies

    Ding, Yu / Fei, Yiyan / Lu, Boxun

    Trends in Pharmacological Sciences

    Abstract: ... limitations and emerging new degrader technologies may greatly broaden the spectrum of targets that could be ... emerging technologies that exploit the lysosomal degradation pathway and discuss their potential ... The proteolysis-targeting chimera (PROTAC) technology provides powerful tools to degrade these “undruggable ...

    Abstract Abstract The traditional drug discovery focuses on identifying direct inhibitors of target proteins. This approach typically relies on a specific measurable biochemical readout and amenable binding sites of which the occupancy directly influences the target protein’s function. These requirements preclude many disease-causing proteins from being “druggable” targets, and these proteins are categorized as “undruggable”. The proteolysis-targeting chimera (PROTAC) technology provides powerful tools to degrade these “undruggable” targets and has become a promising approach for drug discovery. However, the PROTAC technology may have limitations and emerging new degrader technologies may greatly broaden the spectrum of targets that could be selectively degraded by harnessing another major degradation pathway in cells. Here we review a few key emerging technologies that exploit the lysosomal degradation pathway and discuss their potential applications as well as limitations.
    Keywords covid19
    Publisher Elsevier
    Document type Article ; Online
    DOI 10.1016/j.tips.2020.04.005
    Database COVID19

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  3. Article ; Online: Two in one: the emerging concept of bifunctional antibodies.

    Rhee, Kaitlin / Zhou, Xin

    Current opinion in biotechnology

    2023  Volume 85, Page(s) 103050

    Abstract: ... now emerging as a promising new drug modality to address previously unmet needs in antibody ... specific downstream consequences such as targeted protein degradation or posttranslational modifications ...

    Abstract Therapeutic antibodies have become indispensable for treating a wide range of diseases, and their significance in drug discovery has expanded considerably over the past few decades. Bifunctional antibodies are now emerging as a promising new drug modality to address previously unmet needs in antibody therapeutics. Distinct from traditional antibodies that operate through an 'occupancy-based' inhibition mechanism, these innovative molecules recruit the protein of interest to a 'biological effector,' initiating specific downstream consequences such as targeted protein degradation or posttranslational modifications. In this review, we emphasize the potential of bifunctional antibodies to tackle diverse biomedical challenges.
    MeSH term(s) Antibodies, Bispecific ; Proteins/metabolism ; Drug Discovery
    Chemical Substances Antibodies, Bispecific ; Proteins
    Language English
    Publishing date 2023-12-23
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1052045-4
    ISSN 1879-0429 ; 0958-1669
    ISSN (online) 1879-0429
    ISSN 0958-1669
    DOI 10.1016/j.copbio.2023.103050
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  4. Article ; Online: Emerging degrader technologies engaging lysosomal pathways.

    Ding, Yu / Xing, Dong / Fei, Yiyan / Lu, Boxun

    Chemical Society reviews

    2022  Volume 51, Issue 21, Page(s) 8832–8876

    Abstract: ... the landscape of small-molecule drugs, new degrader technologies harnessing alternative degradation machineries ... degrader technologies engaging lysosomal pathways through different mechanisms including AUTACs, AUTOTACs ... degrader technologies. Finally, we will briefly summarize the current status of these degrader technologies ...

    Abstract Targeted protein degradation (TPD) provides unprecedented opportunities for drug discovery. While the proteolysis-targeting chimera (PROTAC) technology has already entered clinical trials and changed the landscape of small-molecule drugs, new degrader technologies harnessing alternative degradation machineries, especially lysosomal pathways, have emerged and broadened the spectrum of degradable targets. We have recently proposed the concept of autophagy-tethering compounds (ATTECs) that hijack the autophagy protein microtubule-associated protein 1A/1B light chain 3 (LC3) for targeted degradation. Other groups also reported degrader technologies engaging lysosomal pathways through different mechanisms including AUTACs, AUTOTACs, LYTACs and MoDE-As. In this review, we analyse and discuss ATTECs along with other lysosomal-relevant degrader technologies. Finally, we will briefly summarize the current status of these degrader technologies and envision possible future studies.
    MeSH term(s) Proteolysis ; Drug Discovery ; Proteins/metabolism ; Autophagy ; Lysosomes/metabolism
    Chemical Substances Proteins
    Language English
    Publishing date 2022-10-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/d2cs00624c
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  5. Article ; Online: Emerging chemistries and molecular designs for flow batteries.

    Zhang, Leyuan / Feng, Ruozhu / Wang, Wei / Yu, Guihua

    Nature reviews. Chemistry

    2022  Volume 6, Issue 8, Page(s) 524–543

    Abstract: Redox flow batteries are a critical technology for large-scale energy storage, offering ... chemistry, performance metrics and characterization. The emerging concepts of hybrid battery design, redox ... targeting strategy, photoelectrode integration and organic redox-active materials present new chemistries ...

    Abstract Redox flow batteries are a critical technology for large-scale energy storage, offering the promising characteristics of high scalability, design flexibility and decoupled energy and power. In recent years, they have attracted extensive research interest, with significant advances in relevant materials chemistry, performance metrics and characterization. The emerging concepts of hybrid battery design, redox-targeting strategy, photoelectrode integration and organic redox-active materials present new chemistries for cost-effective and sustainable energy storage systems. This Review summarizes the recent development of next-generation redox flow batteries, providing a critical overview of the emerging redox chemistries of active materials from inorganics to organics. We discuss electrochemical characterizations and critical performance assessment considering the intrinsic properties of the active materials and the mechanisms that lead to degradation of energy storage capacity. In particular, we highlight the importance of advanced spectroscopic analysis and computational studies in enabling understanding of relevant mechanisms. We also outline the technical requirements for rational design of innovative materials and electrolytes to stimulate more exciting research and present the prospect of this field from aspects of both fundamental science and practical applications.
    Language English
    Publishing date 2022-06-17
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2397-3358
    ISSN (online) 2397-3358
    DOI 10.1038/s41570-022-00394-6
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  6. Article: Circularity assessment tool development for construction projects in emerging economies

    Tokazhanov, Galym / Galiyev, Olzhas / Lukyanenko, Artyom / Nauyryzbay, Aslan / Ismagulov, Rassul / Durdyev, Serdar / Turkyilmaz, Ali / Karaca, Ferhat

    Journal of cleaner production. 2022 Aug. 15, v. 362

    2022  

    Abstract: ... perform notably differently in terms of circularity depending on methods of construction, technologies ... Intending to close the loop of product life cycles and substitute for the linear economy, a new ... concept of circular economy (CE) has emerged. Although relatively novel, the concept of CE has gained ...

    Abstract Intending to close the loop of product life cycles and substitute for the linear economy, a new concept of circular economy (CE) has emerged. Although relatively novel, the concept of CE has gained significant momentum worldwide. CE can potentially help to solve the problem of resource depletion and environmental degradation. However, measuring circularity remains a question and a challenge for various stakeholders. This work aimed to propose an assessment tool to measure the circularity of construction projects. Through a systematic literature review, existing circularity measurement methods, tools, and actions associated with circularity in the construction industry were reviewed. A list of critical circularity actions was identified. Kazakhstan was selected as an emerging economy country to validate the tool. A survey was conducted among professionals in the construction industry to determine the importance of every action and the legislative readiness of local laws to support those actions. The proposed tool (CAT2022) was tailored to measure the circularity degree of construction projects in the selected emerging economy country. As part of the proposed circularity measurement tool, the study also provided several assessments to demonstrate the criteria in the evaluation and their fulfillment of the actions concerning circularity. The results show that projects perform notably differently in terms of circularity depending on methods of construction, technologies implemented, company business model, energy and material efficiency practices. In line with the common assumption that projects certified by green building rating systems are more “circular” than others, our findings indicated that LEED-certified buildings and buildings implementing modular construction methods tend to receive high circularity scores.
    Keywords circular economy ; construction industry ; energy ; environmental degradation ; stakeholders ; surveys ; Kazakhstan
    Language English
    Dates of publication 2022-0815
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 0959-6526
    DOI 10.1016/j.jclepro.2022.132293
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  7. Article: Ionic liquid gel microspheres as an emerging platform for constructing liquid compartment microreactors

    He, Dongqing / Cao, Dezhou / Ben, Chuxuan / Lan, Yalin / Zhang, He / Jiang, Meijiao / Wu, Shuyao / Zhang, Yu / Meng, Qing Bo / Song, Xi-Ming

    Green chemistry. 2022 Aug. 1, v. 24, no. 15

    2022  

    Abstract: Flow chemistry technology innovatively integrates the traditional independent experimental ... of the pollutants by the BiOBr@ILG-microspheres. This work provides a new research strategy for constructing liquid ... of ciprofloxacin for a long time, due to the synergic effect of the enrichment and catalytic degradation ...

    Abstract Flow chemistry technology innovatively integrates the traditional independent experimental operation processes, speeds up reaction rates and, especially, can be applied in special reactions that are hazardous or under difficult reaction conditions, being beneficial for the development of green chemistry and laboratory automation. In flow chemistry, the application of traditional pipeline microreactors is usually limited by blockage, corrosion and difficult maintenance. The micro/nanomaterials-based microreactors for flow chemistry are supposed to solve these problems. Herein, we report a novel solid–liquid composite microreactor (BiOBr@ILG-microspheres) with ionic liquid compartments based on ionic liquid gel microspheres (ILG-microspheres) and a typical photocatalyst, BiOBr. The BiOBr@ILG-microspheres show high photodegradation performance, which is attributed to the enrichment of organic substrates by the ILG-microspheres, the efficient charge transfer microenvironment of the internal ionic liquids (ILs), and the flower-like heterostructure of the microspheres that hosts abundant active sites. Furthermore, the BiOBr@ILG-microspheres are embedded in a poly(vinyl alcohol) (PVA) hydrogel to build a multi-liquid phase membrane, which exhibits promising performance in removing pollutants continuously from flowing water with an ∼100% removal rate of ciprofloxacin for a long time, due to the synergic effect of the enrichment and catalytic degradation of the pollutants by the BiOBr@ILG-microspheres. This work provides a new research strategy for constructing liquid compartment microreactors with a synergistic effect of extraction–catalysis using the novel developed ILG-microspheres, which will attract widespread interest because it is in accordance with the concept of green chemistry.
    Keywords automation ; ciprofloxacin ; corrosion ; green chemistry ; hydrogels ; ionic liquids ; liquids ; microparticles ; photocatalysts ; photolysis ; research planning ; synergism
    Language English
    Dates of publication 2022-0801
    Size p. 5952-5964.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2006274-6
    ISSN 1463-9270 ; 1463-9262
    ISSN (online) 1463-9270
    ISSN 1463-9262
    DOI 10.1039/d2gc01763f
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  8. Article ; Online: Emerging technologies in pediatric gynecology: new paradigms in women's health care.

    Wancura, Megan / McCracken, Jennifer M / Steen, Emily / Cosgriff-Hernandez, Elizabeth / Keswani, Sundeep / Hakim, Julie C-E

    Current opinion in obstetrics & gynecology

    2019  Volume 31, Issue 5, Page(s) 309–316

    Abstract: ... of pediatric, adolescent and adult gynecological patients with new innovative concepts and tools. ... Recent findings: The opportunities for concept, treatment, instrument, and knowledge-transfer innovation ... creation using magnets, improving postoperative vaginal wound healing through newly designed and degradable ...

    Abstract Purpose of review: The current review highlights the complexity of the pediatric and adolescent gynecology subspecialty as well as the recent and exciting opportunities for innovation within the field.
    Recent findings: The opportunities for concept, treatment, instrument, and knowledge-transfer innovation to better serve the specific needs of pediatric gynecology patients include novel approaches to neovagina creation using magnets, improving postoperative vaginal wound healing through newly designed and degradable vaginal stents, and complex Mullerian reconstructive surgical planning using virtual reality immersive experiential training.
    Summary: There is a significant window of opportunity to address the needs of pediatric, adolescent and adult gynecological patients with new innovative concepts and tools.
    MeSH term(s) Adolescent ; Child ; Female ; Gynecology/education ; Gynecology/methods ; Humans ; Pediatrics/education ; Pediatrics/methods ; Vagina/abnormalities ; Vagina/surgery
    Language English
    Publishing date 2019-07-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1049382-7
    ISSN 1473-656X ; 1040-872X
    ISSN (online) 1473-656X
    ISSN 1040-872X
    DOI 10.1097/GCO.0000000000000563
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  9. Article: Emerging technologies of algae‐based wastewater remediation for bio‐fertilizer production: a promising pathway to sustainable agriculture

    Zou, Yao / Zeng, Qingqing / Li, Huankai / Liu, Hui / Lu, Qian

    Journal of chemical technology and biotechnology. 2021 Mar., v. 96, no. 3

    2021  

    Abstract: ... technologies of algae‐based wastewater remediation for bio‐fertilizer production will bring human beings ... such as presence of new pollution factors in wastewater, high cost of algal biomass, contamination of algal ... into a new era of environmentally‐friendly, high‐yield, and resource‐recycling agriculture. © 2020 Society ...

    Abstract Soil degradation, overuse of chemical fertilizer, and biodiversity loss are serious problems challenging the sustainable development of modern agriculture. In recent years, owing to the advantages of algae biotechnology in nutrients recovery and soil improvement, the integration of algae‐based wastewater remediation and algal bio‐fertilizer production is emerging into the limelight. In this work, we emphasize on the progresses achieved in the fields of biomass production by algae cultivation in wastewater and application of algal bio‐fertilizers. Particularly, three types of algal bio‐fertilizers, including slow‐release bio‐fertilizer, nitrogen‐fixing cyanobacteria, and liquid bio‐fertilizer, widely evaluated and utilized in agriculture are introduced. To prevent the overly optimistic prediction of algal bio‐fertilizer in a real‐world application, we point out the challenges and technical defects, such as presence of new pollution factors in wastewater, high cost of algal biomass, contamination of algal biomass in wastewater, low productivity of algae and valuable components, high water consumption, and potential threats of cyanobacteria to the environment, that prevent the concept of integrating algae‐based wastewater remediation and algal bio‐fertilizer production from becoming a reality. Based on our knowledge and experience, potential solutions to the aforementioned problems are discussed in depth. It is expected that the emerging technologies of algae‐based wastewater remediation for bio‐fertilizer production will bring human beings into a new era of environmentally‐friendly, high‐yield, and resource‐recycling agriculture. © 2020 Society of Chemical Industry (SCI)
    Keywords algae ; biodiversity ; biofertilizers ; biomass production ; biotechnology ; humans ; liquids ; mineral fertilizers ; nitrogen-fixing cyanobacteria ; pollution ; prediction ; remediation ; soil ; soil degradation ; sustainable agriculture ; wastewater
    Language English
    Dates of publication 2021-03
    Size p. 551-563.
    Publishing place John Wiley & Sons, Ltd.
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 1479465-2
    ISSN 1097-4660 ; 0268-2575
    ISSN (online) 1097-4660
    ISSN 0268-2575
    DOI 10.1002/jctb.6602
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