Article ; Online: MAFLD in COVID-19 patients: an insidious enemy.
Expert review of gastroenterology & hepatology
2020 Volume 14, Issue 10, Page(s) 867–872
Abstract: ... viral shedding time. The presence of fibrosis in MAFLD patients is another risk factor for severity of COVID-19 ... during COVID-19 and a more severe infection occurs in patients with pre-existing liver diseases ... patients had a higher risk of progression to severe COVID-19, higher abnormal liver tests and longer ...
| Abstract | The pandemic Sars-CoV-2 infection represents a dramatic health challenge worldwide. Pneumonia is considered the major damage caused by the virus. However, recent data have highlighted the impact of the Sars-CoV-2 related disease namely COVID-19 on the liver. Hepatic abnormalities significantly increase during COVID-19 and a more severe infection occurs in patients with pre-existing liver diseases, among which the most frequent is metabolic-associated fatty liver disease (MAFLD). It has been described that MAFLD patients had a higher risk of progression to severe COVID-19, higher abnormal liver tests and longer viral shedding time. The presence of fibrosis in MAFLD patients is another risk factor for severity of COVID-19. Due to the overgrowing prevalence of MAFLD, it could be speculated that a large proportion of the population might be at risk of severe COVID-19 and the identification of these patients possibly by using liver enzymes as risk predictors may be crucial for an early diagnosis and for the management of the infection. |
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| MeSH term(s) | Aged ; Betacoronavirus ; COVID-19 ; Comorbidity ; Coronavirus Infections/epidemiology ; Fatty Liver/epidemiology ; Fatty Liver/etiology ; Female ; Global Health ; Humans ; Male ; Metabolic Syndrome/complications ; Metabolic Syndrome/epidemiology ; Pandemics ; Pneumonia, Viral/epidemiology ; Prevalence ; Risk Factors ; SARS-CoV-2 |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-08-04 |
| Publishing country | England |
| Document type | Editorial |
| ZDB-ID | 2481021-6 |
| ISSN | 1747-4132 ; 1747-4124 |
| ISSN (online) | 1747-4132 |
| ISSN | 1747-4124 |
| DOI | 10.1080/17474124.2020.1801417 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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