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  1. Article ; Online: COVID-19-the risk of secondary transmission among households quantified.

    Donnelly, Seamas C

    QJM : monthly journal of the Association of Physicians

    2021  Volume 113, Issue 12, Page(s) 839

    MeSH term(s) COVID-19/transmission ; Family Characteristics ; Humans ; Risk Factors ; SARS-CoV-2
    Language English
    Publishing date 2021-01-05
    Publishing country England
    Document type Introductory Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcaa308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19, social determinants of transmission in the home. A population-based study.

    Soriano López, Jesús / Gómez Gómez, Jesús Humberto / Ballesta-Ruiz, Monica / Garcia-Pina, Rocio / Sánchez-Rodríguez, Inés / Bonilla-Escobar, Bertha A / Salmerón, Diego / Rodríguez, Berta Suárez / Chirlaque, Maria-Dolores

    European journal of public health

    2024  

    Abstract: ... dynamics of numerous infectious diseases. For Coronavirus Disease-2019 (COVID-19), transmission ... within the home constitutes the majority exposure context. The risk of infection in this setting can be quantified ... by the household/intra-family secondary attack rate (SAR). In the literature, there are discrepancies ...

    Abstract Background: Studying transmission within the home is essential to understand the transmission dynamics of numerous infectious diseases. For Coronavirus Disease-2019 (COVID-19), transmission within the home constitutes the majority exposure context. The risk of infection in this setting can be quantified by the household/intra-family secondary attack rate (SAR). In the literature, there are discrepancies in these values and little information about its social determinants. The aim of this study was to investigate transmission in the home by analyzing the influence of occupational social class, country of origin and gender/sex.
    Methods: This was a retrospective cohort study of a population registry of cohabiting contacts with COVID-19 cases diagnosed from 15 June to 23 December 2020, in the Murcia Region. The household SAR was analyzed considering the characteristics of the primary case (sex, age, symptoms, occupational social class, country of origin and number of people in the household) and contact (age and sex) using a multilevel binary logistic regression model.
    Results: Among the 37 727 contacts included, the intra-family SAR was 39.1%. The contacts of confirmed primary cases in the migrant population (Africa and Latin America) had higher attack rates, even after adjusting for the other variables. Older age and female sex were independent risk factors for contracting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) within the home.
    Conclusion: There was greater intra-domiciliary transmission among immigrants, likely related to the conditions of the home and situation of social vulnerability. Women were more likely to be infected by transmission from a cohabiting infected individual.
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1129243-x
    ISSN 1464-360X ; 1101-1262
    ISSN (online) 1464-360X
    ISSN 1101-1262
    DOI 10.1093/eurpub/ckae016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A stochastic contact network model for assessing outbreak risk of COVID-19 in workplaces.

    Guo, Xi / Gupta, Abhineet / Sampat, Anand / Zhai, Chengwei

    PloS one

    2022  Volume 17, Issue 1, Page(s) e0262316

    Abstract: ... plans for bringing workers back on-site, they are in need of tools to assess the risk of COVID-19 ... for their employees in the workplaces. This study aims to fill the gap in risk modeling of COVID-19 outbreaks ... for providing short-term forecasts of COVID-19 cases for workplaces and for quantifying the effectiveness ...

    Abstract The COVID-19 pandemic has drastically shifted the way people work. While many businesses can operate remotely, a large number of jobs can only be performed on-site. Moreover as businesses create plans for bringing workers back on-site, they are in need of tools to assess the risk of COVID-19 for their employees in the workplaces. This study aims to fill the gap in risk modeling of COVID-19 outbreaks in facilities like offices and warehouses. We propose a simulation-based stochastic contact network model to assess the cumulative incidence in workplaces. First-generation cases are introduced as a Bernoulli random variable using the local daily new case rate as the success rate. Contact networks are established through randomly sampled daily contacts for each of the first-generation cases and successful transmissions are established based on a randomized secondary attack rate (SAR). Modification factors are provided for SAR based on changes in airflow, speaking volume, and speaking activity within a facility. Control measures such as mask wearing are incorporated through modifications in SAR. We validated the model by comparing the distribution of cumulative incidence in model simulations against real-world outbreaks in workplaces and nursing homes. The comparisons support the model's validity for estimating cumulative incidences for short forecasting periods of up to 15 days. We believe that the current study presents an effective tool for providing short-term forecasts of COVID-19 cases for workplaces and for quantifying the effectiveness of various control measures. The open source model code is made available at github.com/abhineetgupta/covid-workplace-risk.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/transmission ; Contact Tracing/methods ; Humans ; Nursing Homes ; Probability ; Stochastic Processes ; Workplace
    Language English
    Publishing date 2022-01-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0262316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Household transmission investigation for Corona Virus Disease 2019 (COVID-19) in a rural and urban population of north India.

    Yadav, Kapil / K J, Subhashini / Meena, Suneeta / Kumar, Rakesh / Kaur, Ravneet / Bairwa, Mohan / Kant, Shashi / Misra, Puneet / Rai, Sanjay K / Ahmad, Mohammad / Rahman, Anisur

    PloS one

    2023  Volume 18, Issue 10, Page(s) e0287048

    Abstract: ... and household contacts to follow strict COVID infection control measures within households ... 1%). The secondary clinical attack rate was 9.3% (95% CI: 7.2-11.8). The risk factors that showed ... secondary transmission of SARS CoV- 2, hence, index cases are recommended to self-isolate and wear masks ...

    Abstract Background: Transmissibility within closed settings, such as households, can provide a strategic way to characterize the virus transmission patterns because the denominator can be well defined. We aimed to characterize the household transmission of Severe Acute Respiratory Syndrome Coronavirus (SARS CoV-2) and its associated risk factors.
    Methods: This prospective case-ascertained study was conducted among the household contacts of laboratory-confirmed SARS CoV-2 cases residing in Ballabgarh, Haryana. We enrolled 148 index cases and their 645 household contacts between December 16, 2020 and June 24, 2021. We defined household contact as any person who had resided in the same household as a confirmed COVID-19 case. Baseline data collection and sample collection for real time- reverse transcriptase polymerase chain reaction (RT-PCR) and IgM/IgG against SARS CoV-2 were done on day 1 visit, and followed for a period of 28 days. RT-PCR was repeated on day 14 or whenever the contact is symptomatic and blood sample for serology was repeated on day 28. We estimated household secondary infection rate (SIR) and other epidemiological indicators-median incubation period and serial interval. We employed binomial logistic regression to quantify risk factors associated with infection.
    Results: The household SIR was 30.5% (95% CI: 27.1-34.1%). The secondary clinical attack rate was 9.3% (95% CI: 7.2-11.8). The risk factors that showed higher susceptibility to infection were household contacts who were the primary care giver of the case, whose index cases were symptomatic, those with underlying medical conditions, those living in overcrowded households, who were sharing toilet with the index cases and also who were not wearing a mask when coming in contact with the case. The median (IQR) incubation period was 4 days (4, 5), mean (SD) serial interval 6.4 (±2.2) days, and median (IQR) serial interval 5 days (5, 7).
    Conclusion: Households favour secondary transmission of SARS CoV- 2, hence, index cases are recommended to self-isolate and wear masks; and household contacts to follow strict COVID infection control measures within households when a family member is infected.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Urban Population ; SARS-CoV-2 ; Family Characteristics ; Family
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0287048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Household transmission investigation for Corona Virus Disease 2019 (COVID-19) in a rural and urban population of north India.

    Kapil Yadav / Subhashini K J / Suneeta Meena / Rakesh Kumar / Ravneet Kaur / Mohan Bairwa / Shashi Kant / Puneet Misra / Sanjay K Rai / Mohammad Ahmad / Anisur Rahman

    PLoS ONE, Vol 18, Iss 10, p e

    2023  Volume 0287048

    Abstract: ... interval 5 days (5, 7). Conclusion Households favour secondary transmission of SARS CoV- 2, hence, index ... contact as any person who had resided in the same household as a confirmed COVID-19 case. Baseline ... Background Transmissibility within closed settings, such as households, can provide a strategic way ...

    Abstract Background Transmissibility within closed settings, such as households, can provide a strategic way to characterize the virus transmission patterns because the denominator can be well defined. We aimed to characterize the household transmission of Severe Acute Respiratory Syndrome Coronavirus (SARS CoV-2) and its associated risk factors. Methods This prospective case-ascertained study was conducted among the household contacts of laboratory-confirmed SARS CoV-2 cases residing in Ballabgarh, Haryana. We enrolled 148 index cases and their 645 household contacts between December 16, 2020 and June 24, 2021. We defined household contact as any person who had resided in the same household as a confirmed COVID-19 case. Baseline data collection and sample collection for real time- reverse transcriptase polymerase chain reaction (RT-PCR) and IgM/IgG against SARS CoV-2 were done on day 1 visit, and followed for a period of 28 days. RT-PCR was repeated on day 14 or whenever the contact is symptomatic and blood sample for serology was repeated on day 28. We estimated household secondary infection rate (SIR) and other epidemiological indicators-median incubation period and serial interval. We employed binomial logistic regression to quantify risk factors associated with infection. Results The household SIR was 30.5% (95% CI: 27.1-34.1%). The secondary clinical attack rate was 9.3% (95% CI: 7.2-11.8). The risk factors that showed higher susceptibility to infection were household contacts who were the primary care giver of the case, whose index cases were symptomatic, those with underlying medical conditions, those living in overcrowded households, who were sharing toilet with the index cases and also who were not wearing a mask when coming in contact with the case. The median (IQR) incubation period was 4 days (4, 5), mean (SD) serial interval 6.4 (±2.2) days, and median (IQR) serial interval 5 days (5, 7). Conclusion Households favour secondary transmission of SARS CoV- 2, hence, index cases are recommended to self-isolate ...
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol.

    Setiabudi, Wega / Hungerford, Daniel / Subramaniam, Krishanthi / Vaselli, Natasha Marcella / Shaw, Victoria E / Wilton, Moon / Vivancos, Roberto / Aston, Stephen / Platt, Gareth / Moitt, Tracy / Jones, Ashley P / Gabbay, Mark / Buchan, Iain / Carrol, Enitan D / Iturriza-Gomara, Miren / Solomon, Tom / Greenhalf, William / Naisbitt, Dean J / Adams, Emily R /
    Cunliffe, Nigel A / Turtle, Lance / French, Neil

    BMJ open

    2021  Volume 11, Issue 3, Page(s) e048317

    Abstract: ... their activity and presence of symptoms. Incidence of infection and household secondary attack rates of COVID-19 ... observational study of a cohort of households in Liverpool City Region, UK, which addresses the transmission ... Methods and analysis: Households in the Liverpool City Region, in which members have not previously ...

    Abstract Introduction: The emergence and rapid spread of COVID-19 have caused widespread and catastrophic public health and economic impact, requiring governments to restrict societal activity to reduce the spread of the disease. The role of household transmission in the population spread of SARS-CoV-2, and of host immunity in limiting transmission, is poorly understood. This paper describes a protocol for a prospective observational study of a cohort of households in Liverpool City Region, UK, which addresses the transmission of SARS-CoV-2 between household members and how immunological response to the infection changes over time.
    Methods and analysis: Households in the Liverpool City Region, in which members have not previously tested positive for SARS-CoV-2 with a nucleic acid amplification test, are followed up for an initial period of 12 weeks. Participants are asked to provide weekly self-throat and nasal swabs and record their activity and presence of symptoms. Incidence of infection and household secondary attack rates of COVID-19 are measured. Transmission of SARS-CoV-2 will be investigated against a range of demographic and behavioural variables. Blood and faecal samples are collected at several time points to evaluate immune responses to SARS-CoV-2 infection and prevalence and risk factors for faecal shedding of SARS-CoV-2, respectively.
    Ethics and dissemination: The study has received approval from the National Health Service Research Ethics Committee; REC Reference: 20/HRA/2297, IRAS Number: 283 464. Results will be disseminated through scientific conferences and peer-reviewed open access publications. A report of the findings will also be shared with participants. The study will quantify the scale and determinants of household transmission of SARS-CoV-2. Additionally, immunological responses before and during the different stages of infection will be analysed, adding to the understanding of the range of immunological response by infection severity.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/transmission ; Humans ; Observational Studies as Topic ; Prospective Studies ; Research Design ; State Medicine ; United Kingdom/epidemiology
    Language English
    Publishing date 2021-03-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2020-048317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV)

    Daniel Hungerford / Neil French / Carrol Gamble / Laura Marsh / Nigel A Cunliffe / Tracy Moitt / Miren Iturriza-Gómara / Chloe Donohue / William Greenhalf / Lance Turtle / Stephen Aston / Milton Ashworth / Laura Booth / Katie Bullock / Terry Foster / Joanna Middleton / William Reynolds / Victoria E Shaw / Eve Wilcock /
    Jane Armstrong / Susan Dobson / Ashley P Jones / Wega Setiabudi / Krishanthi Subramaniam / Natasha Marcella Vaselli / Moon Wilton / Gareth Platt / Dean J Naisbitt / Emily R Adams / Lynnette Crossley / Neil Joseph / Lee D Troughton / Samantha Kilada / Katharine Abba / Victoria Simpson / Lynsey Goodwin / Rachael Daws / Shiva S Forootan / Rachel Press / Vida Spaine / Lesley Hands / Kate Bradfield / Carol McNally / Silviya Balabanova / Lynsey Finnetty / Paul J Thomson / Monday Ogese / Kareena Adair / Liam Farrell / Kanoot Jaruthamsophon

    BMJ Open, Vol 11, Iss

    a study protocol

    2021  Volume 3

    Abstract: ... and presence of symptoms. Incidence of infection and household secondary attack rates of COVID-19 are ... observational study of a cohort of households in Liverpool City Region, UK, which addresses the transmission ... Methods and analysis Households in the Liverpool City Region, in which members have not previously tested ...

    Abstract Introduction The emergence and rapid spread of COVID-19 have caused widespread and catastrophic public health and economic impact, requiring governments to restrict societal activity to reduce the spread of the disease. The role of household transmission in the population spread of SARS-CoV-2, and of host immunity in limiting transmission, is poorly understood. This paper describes a protocol for a prospective observational study of a cohort of households in Liverpool City Region, UK, which addresses the transmission of SARS-CoV-2 between household members and how immunological response to the infection changes over time.Methods and analysis Households in the Liverpool City Region, in which members have not previously tested positive for SARS-CoV-2 with a nucleic acid amplification test, are followed up for an initial period of 12 weeks. Participants are asked to provide weekly self-throat and nasal swabs and record their activity and presence of symptoms. Incidence of infection and household secondary attack rates of COVID-19 are measured. Transmission of SARS-CoV-2 will be investigated against a range of demographic and behavioural variables. Blood and faecal samples are collected at several time points to evaluate immune responses to SARS-CoV-2 infection and prevalence and risk factors for faecal shedding of SARS-CoV-2, respectively.Ethics and dissemination The study has received approval from the National Health Service Research Ethics Committee; REC Reference: 20/HRA/2297, IRAS Number: 283 464. Results will be disseminated through scientific conferences and peer-reviewed open access publications. A report of the findings will also be shared with participants. The study will quantify the scale and determinants of household transmission of SARS-CoV-2. Additionally, immunological responses before and during the different stages of infection will be analysed, adding to the understanding of the range of immunological response by infection severity.
    Keywords Medicine ; R
    Subject code 910
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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