Article ; Online: New daily persistent headache after SARS-CoV-2 infection: a report of two cases.
2021 Volume 42, Issue 10, Page(s) 3965–3968
Abstract: ... Methods: Two patients with persistent headache and Sars-CoV-2 infection were identified. Both underwent ... with relief of symptoms.: Conclusions: Our report described two cases of probable NDPH due to SARS-CoV-2 ... both in the acute and the healing phase of the infection. New daily persistent headache (NDPH) is a primary headache ...
| Abstract | Background: The 2019 Coronavirus (SARS-CoV-2) is a novel respiratory virus which causes Coronavirus Disease19 (COVID-19). Although the predominant clinical picture of COVID-19 is represented by respiratory symptoms, neurological manifestations are being increasingly recognized. Headache, in particular migraine-like and tension types, has been largely reported in patients suffering from COVID-19 both in the acute and the healing phase of the infection. New daily persistent headache (NDPH) is a primary headache characterized by persistent and daily painful symptoms, with pain becoming continuous and non-remitting within 24 h, and lasting more than 3 months. Even though an increasing number of reports describe patients who develop a persistent headache, diagnosis of NPDH has been rarely explored in the context of COVID-19. Methods: Two patients with persistent headache and Sars-CoV-2 infection were identified. Both underwent a full clinical and neuroradiological evaluation. Blood sample with inflammatory biomarkers search was also performed. Results: According to International Classifications of Headache Disorders diagnosis of probable new daily persistent headache was made. The treatment with high doses of steroids was associated with relief of symptoms. Conclusions: Our report described two cases of probable NDPH due to SARS-CoV-2 infection. Clinical evaluation of COVID-19 patients presenting with persistent headache should take into consideration NDPH. Given the supposed major role for neuroinflammation in the genesis of Sars-CoV-2-driven NDPH, immunomodulatory therapy should be promptly started. In line with this hypothesis, we obtained a good therapeutic response to short-term high dose of corticosteroids. |
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| MeSH term(s) | COVID-19 ; Headache/drug therapy ; Headache/etiology ; Headache Disorders/diagnosis ; Headache Disorders/drug therapy ; Headache Disorders/etiology ; Humans ; Migraine Disorders ; SARS-CoV-2 | |||||
| Language | English | |||||
| Publishing date | 2021-07-15 | |||||
| Publishing country | Italy | |||||
| Document type | Case Reports ; Journal Article | |||||
| ZDB-ID | 2016546-8 | |||||
| ISSN | 1590-3478 ; 1590-1874 | |||||
| ISSN (online) | 1590-3478 | |||||
| ISSN | 1590-1874 | |||||
| DOI | 10.1007/s10072-021-05444-3 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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