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  1. Article ; Online: Status epilepticus and COVID-19: A systematic review.

    Dono, Fedele / Nucera, Bruna / Lanzone, Jacopo / Evangelista, Giacomo / Rinaldi, Fabrizio / Speranza, Rino / Troisi, Serena / Tinti, Lorenzo / Russo, Mirella / Di Pietro, Martina / Onofrj, Marco / Bonanni, Laura / Assenza, Giovanni / Vollono, Catello / Anzellotti, Francesca / Brigo, Francesco

    Epilepsy & behavior : E&B

    2021  Volume 118, Page(s) 107887

    Abstract: ... and status epilepticus (SE). In this systematic review, we summarized the available data on clinical ... features, diagnosis, and therapy of COVID-19-related SE.: Methods: We performed a systematic search ... coronavirus Disease (COVID-19) a pandemic. During the first and second waves of the pandemic spread, there ...

    Abstract Purpose: In March 2020, the World Health Organization declared the SARS-CoV-2 infection-related coronavirus Disease (COVID-19) a pandemic. During the first and second waves of the pandemic spread, there have been several reports of COVID-19-associated neurological manifestations, including acute seizures and status epilepticus (SE). In this systematic review, we summarized the available data on clinical features, diagnosis, and therapy of COVID-19-related SE.
    Methods: We performed a systematic search of the literature to identify data on demographics, clinical, neurophysiological, and neuroradiological data of patients with COVID-19-related SE. We used regression models (linear or logistic) with a stepwise forward method to identify features associated with mortality or severity of SE.
    Results: Thirty-nine articles were included with a total of 47 cases of SE associated with COVID-19. Age, time between the acute respiratory phase of SARS-CoV-2 infection and SE onset, and hospitalization correlated with a higher SE severity as assessed by quantitative validated scales.
    Conclusions: SE can be a neurological manifestation of SARS-CoV-2 infection. Although a possible association between SE and COVID-19 has been reported, the exact mechanisms are still not fully understood. Systemic inflammatory syndrome due to cytokine release could play a role in COVID-19-related SE.
    MeSH term(s) COVID-19 ; Humans ; Pandemics ; SARS-CoV-2 ; Seizures ; Status Epilepticus/diagnosis ; Status Epilepticus/epidemiology ; Status Epilepticus/etiology
    Language English
    Publishing date 2021-03-17
    Publishing country United States
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2021.107887
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: New-Onset Refractory Status Epilepticus Secondary to COVID-19 Infection in Adults: A Systematic Review.

    Arif, Aabiya / Chavarria, Yeny / Qamar, Mohammad Aadil / Tebha, Sameer Saleem / Butt, Mehwish / Qamar, Khulud / Yosufi, Abubakr

    Neuropsychiatric disease and treatment

    2022  Volume 18, Page(s) 1951–1961

    Abstract: ... secondary to COVID-19 were included in this review. The status epilepticus severity score (STESS) was ... of 61.6 ± 19.0-year olds. The most common type of status epilepticus reported in our study population ... Given the observed association of STESS with the aging population and IHO of status epilepticus, special attention is ...

    Abstract Background: New-onset refractory status epilepticus (NORSE) has been reported in the scientific literature as a phenomenon associated with the COVID-19 infection. Given the resurgence of the newer variants of COVID-19 added with its multi-system manifestations, this project was conducted to study the clinical picture of NORSE secondary to COVID-19 infection.
    Methods: Three electronic databases were searched using an extensive search strategy from November 2019 to December 2021. Patients reporting NORSE secondary to COVID-19 were included in this review. The status epilepticus severity score (STESS) was calculated by the study authors for individual patients. Statistical analysis was performed using SPSS version 26 with a
    Results: After screening, 12 patients were included in this study with a mean age of 61.6 ± 19.0-year olds. The most common type of status epilepticus reported in our study population was non-convulsive status epilepticus (NCSE) (7 out of 12 patients, 58.3%). The linear regression model revealed that STESS scores were significantly influenced by patients' age (
    Conclusion: Given the observed association of STESS with the aging population and IHO of status epilepticus, special attention is due to the caretakers of this population, while further studies are needed to further build upon this review.
    Language English
    Publishing date 2022-08-30
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2186503-6
    ISSN 1178-2021 ; 1176-6328
    ISSN (online) 1178-2021
    ISSN 1176-6328
    DOI 10.2147/NDT.S381018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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