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  1. Article ; Online: COVID-19-associated venous thromboembolism: risk of recurrence and major bleeding.

    Demelo-Rodriguez, Pablo / Alonso-Beato, Rubén / Jara-Palomares, Luis / Galeano-Valle, Francisco / Bura-Riviere, Alessandra / Visonà, Adriana / Francisco, Iria / Vidal, Gemma / López-Ruiz, Antonio / Monreal, Manuel

    Research and practice in thrombosis and haemostasis

    2023  Volume 7, Issue 7, Page(s) 102206

    Abstract: ... rates of VTE recurrences and major bleeding in patients with COVID-19-associated VTE versus ... included 1,747 patients with COVID-19-associated VTE and 8,711 with VTE without COVID-19. Patients ... with COVID-19-associated VTE were more likely to be hospitalized at baseline and to present ...

    Abstract Background: Complications under anticoagulant treatment in patients with COVID-19-associated venous thromboembolism (VTE) have not been consistently reported.
    Objectives: This study aimed to compare the 90-day rates of VTE recurrences and major bleeding in patients with COVID-19-associated VTE versus those with VTE without COVID-19.
    Methods: We used the RIETE registry to compare the 3-month outcomes in patients with COVID-19-associated VTE versus those with VTE without COVID-19.
    Results: The study included 1,747 patients with COVID-19-associated VTE and 8,711 with VTE without COVID-19. Patients with COVID-19-associated VTE were more likely to be hospitalized at baseline and to present with pulmonary embolism. During the first 90 days, 123 patients (1.17%) developed VTE recurrences, and 266 (2.54%) experienced major bleeding. Patients with COVID-19-associated VTE had a similar rate of VTE recurrences (0.9% vs 1.2%) but a higher rate of major bleeding (4.6% vs 2.1%;
    Conclusion: Patients with COVID-19-associated VTE had a 5-fold higher rate of major bleeding than VTE recurrences during the first 90 days of anticoagulation. In VTE patients without COVID-19, both rates were similar. These findings highlight the importance of carefully monitoring and optimizing anticoagulation in these patients.
    Language English
    Publishing date 2023-09-20
    Publishing country United States
    Document type Journal Article
    ISSN 2475-0379
    ISSN (online) 2475-0379
    DOI 10.1016/j.rpth.2023.102206
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  2. Article ; Online: Bleeding and Bleeding Risk in COVID-19.

    Dorgalaleh, Akbar

    Seminars in thrombosis and hemostasis

    2020  Volume 46, Issue 7, Page(s) 815–818

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Prognosis ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-08
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0040-1713434
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  3. Article: Thrombosis and Bleeding Risk Scores Are Strongly Associated with Mortality in Hospitalized Patients with COVID-19: A Multicenter Cohort Study.

    Iam-Arunthai, Kunapa / Chamnanchanunt, Supat / Thungthong, Pravinwan / Intalapaporn, Poj / Nakhahes, Chajchawan / Suwanban, Tawatchai / Rojnuckarin, Ponlapat

    Journal of clinical medicine

    2024  Volume 13, Issue 5

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13051437
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  4. Article ; Online: Unfractionated Heparin Safety in COVID-19: Incidence and Risks of Bleeding Complications in Japan.

    Sato, Lubna / Iwamoto, Noriko / Kakumoto, Yuko / Tsuzuki, Shinya / Togano, Tomiteru / Ishikane, Masahiro / Okumura, Nobumasa / Yamada, Gen / Inada, Makoto / Suzuki, Tetsuya / Hojo, Masayuki / Takasaki, Jin / Sasaki, Ryo / Kimura, Akio / Teruya, Katsuji / Okamoto, Tatsuya / Hayakawa, Kayoko / Hara, Hisao / Iseki, Ken /
    Ohmagari, Norio

    Journal of atherosclerosis and thrombosis

    2024  

    Abstract: ... high. Critical COVID-19 and older age were risk factors for bleeding complications. ... propensity score matching were used to assess risk factors for bleeding complications and their impact on mortality ... aOR], 3.89; 95% confidence interval [CI], 1.01-15.0; P＜.05) and COVID-19 severity (aOR, 35.9; 95% CI ...

    Abstract Aim: Several studies have shown the efficacy and safety of low-molecular-weight heparin use in coronavirus disease 2019 (COVID-19), but that of unfractionated heparin (UFH) has not been investigated. We investigated the prevalence of bleeding complications during UFH administration, its impact on mortality, and the risk factors of bleeding outcomes associated with UFH.
    Methods: This retrospective cohort study was conducted at a single-center tertiary care hospital, including hospitalized patients with COVID-19. The primary outcomes were measured as the prevalence of bleeding complications during hospitalization, and the secondary outcomes were thromboembolic events and 60-day mortality rates. Logistic regression analysis and propensity score matching were used to assess risk factors for bleeding complications and their impact on mortality.
    Results: Among 1035 included patients, 516 patients were treated with UFH. Twelve (2.3%) patients in the UFH group experienced major bleeding. The prevalence of major bleeding in patients treated with therapeutic-dose UFH was 9.2%. Logistic regression analysis showed that age ≥ 60 years (adjusted odds ratio [aOR], 3.89; 95% confidence interval [CI], 1.01-15.0; P＜.05) and COVID-19 severity (aOR, 35.9; 95% CI, 4.57-282; P ＜.05) were associated with major bleeding complications. After propensity score matching, 11 major and 11 non-major bleeding cases (including minor bleeding) were matched. The 60-day cumulative mortality rate between the two groups did not differ significantly (P=.13, log-rank test).
    Conclusions: The incidence of major bleeding in COVID-19 patients using therapeutic-dose UFH was relatively high. Critical COVID-19 and older age were risk factors for bleeding complications.
    Language English
    Publishing date 2024-02-14
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2011474-6
    ISSN 1880-3873 ; 1340-3478
    ISSN (online) 1880-3873
    ISSN 1340-3478
    DOI 10.5551/jat.64448
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  6. Article ; Online: Risk assessment of venous thromboembolism and bleeding in COVID-19 patients.

    Wang, Lan / Zhao, Lan / Li, Feng / Liu, Ji / Zhang, Li / Li, Qiuhong / Gu, Jin / Liang, Shuo / Zhao, Qinhua / Liu, Jinmin / Xu, Jin-Fu

    The clinical respiratory journal

    2022  Volume 16, Issue 3, Page(s) 182–189

    Abstract: ... in COVID-19. Our study aims to identify in-hospital VTE risk and bleeding risk in COVID-19 patients ... 7%) patients with COVID-19 were at high risk for VTE according to Padua prediction score and 9 (6.5 ... in-hospital VTE and bleeding risk by Padua Prediction Score and Improve bleed risk assessment model ...

    Abstract Background: The coronavirus disease 2019 (COVID-19) is a newly recognized illness that has spread rapidly all over the world. More and more reports highlight the risk of venous thromboembolism (VTE) in COVID-19. Our study aims to identify in-hospital VTE risk and bleeding risk in COVID-19 patients.
    Methods: We retrospectively studied 138 consecutively enrolled patients with COVID-19 and identified in-hospital VTE and bleeding risk by Padua Prediction Score and Improve bleed risk assessment model. The clinical data and features were analyzed in VTE patients.
    Results: Our findings identified that 23 (16.7%) patients with COVID-19 were at high risk for VTE according to Padua prediction score and 9 (6.5%) patients were at high risk of bleeding for VTE prophylaxis according to Improve prediction score. Fifteen critically ill patients faced double high risk from thrombosis (Padua score more than 4 points in all 15 [100%] patients) and hemorrhage (Improve score more than 7 points in 9 [60.0%] patients). Thrombotic events were identified in four patients (2.9%) of all COVID-19 patients. All of them were diagnosed with deep vein thrombosis by ultrasound 3 to 18 days after admission. Three (75.0%) were critically ill patients, which means that the incidence of VTE among critically ill patients was 20%. One major hemorrhage happened in critically ill patients during VTE treatment.
    Conclusion: Critically ill patients with COVID-19 suffered both a high risk of thrombosis and bleeding risks. More effective VTE prevention strategies based on an individual assessment of bleeding risks were necessary for critically ill patients with COVID-19.
    MeSH term(s) Anticoagulants/therapeutic use ; COVID-19/complications ; COVID-19/epidemiology ; Hemorrhage/epidemiology ; Hemorrhage/etiology ; Humans ; Retrospective Studies ; Risk Assessment ; Risk Factors ; SARS-CoV-2 ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/etiology ; Venous Thromboembolism/prevention & control
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-01-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2442214-9
    ISSN 1752-699X ; 1752-6981
    ISSN (online) 1752-699X
    ISSN 1752-6981
    DOI 10.1111/crj.13467
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  7. Article ; Online: Bleeding and Bleeding Risk in COVID-19

    Dorgalaleh, Akbar

    Seminars in Thrombosis and Hemostasis

    2020  Volume 46, Issue 07, Page(s) 815–818

    Keywords Hematology ; Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Georg Thieme Verlag KG
    Publishing country de
    Document type Article ; Online
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0040-1713434
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  8. Article: Bleeding and Bleeding Risk in COVID-19

    Dorgalaleh, Akbar

    Seminars in Thrombosis and Hemostasis

    (Maintaining Hemostasis and Preventing Thrombosis in COVID-19—Part I)

    2020  Volume 46, Issue 07, Page(s) 815–818

    Series title Maintaining Hemostasis and Preventing Thrombosis in COVID-19—Part I
    Language English
    Publishing date 2020-06-08
    Publisher Thieme Medical Publishers
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0040-1713434
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  9. Article ; Online: Anticoagulation and bleeding risk in patients with COVID-19.

    Musoke, Nancy / Lo, Kevin Bryan / Albano, Jeri / Peterson, Eric / Bhargav, Ruchika / Gul, Fahad / DeJoy, Robert / Salacup, Grace / Pelayo, Jerald / Tipparaju, Padmavathi / Azmaiparashvili, Zurab / Patarroyo-Aponte, Gabriel / Rangaswami, Janani

    Thrombosis research

    2020  Volume 196, Page(s) 227–230

    Abstract: ... the patterns of anticoagulation use in COVID-19 patients and the risk of related bleeding.: Methods: This is ... with Coronavirus Disease 2019 (COVID-19) while potential bleeding risks remain. Our study characterizes ... of bleeding. Bleeding in turn exhibited trends towards higher inpatient death among patients with COVID-19 ...

    Abstract Background: There is no current standardized approach to anticoagulation in patients with Coronavirus Disease 2019 (COVID-19) while potential bleeding risks remain. Our study characterizes the patterns of anticoagulation use in COVID-19 patients and the risk of related bleeding.
    Methods: This is a single center retrospective analysis of 355 adult patients with confirmed diagnosis of COVID-19 from March 1 to May 31, 2020. Chi-square was used to analyze the relationship between degree of anticoagulant dose and bleeding events by site. Multivariable logistic regression was used to look at factors associated with inpatient death.
    Results: 61% of patients were being treated with prophylactic doses of anticoagulation, while 7% and 29% were being treated with sub-therapeutic and therapeutic anticoagulation (TA) doses respectively. In 44% of patients, we found that the decision to escalate the dose of anticoagulation was based on laboratory values characterizing the severity of COVID-19 such as rising D-dimer levels. There were significantly higher rates of bleeding from non-CNS/non-GI sites (p = 0.039) and from any bleeding site overall (p = 0.019) with TA. TA was associated with significantly higher rates of inpatient death (41.6% vs 15.3% p < 0.0001) compared to those without. All patients who developed CNS hemorrhage died p = 0.011. After multivariable logistic regression, only age OR 1.04 95% CI (1.01 to 1.07) p = 0.008 and therapeutic anticoagulation was associated with inpatient mortality OR 6.16 95% CI (2.96 to 12.83) p ≤ 0.0001.
    Conclusion: The use of TA was significantly associated with increased risk of bleeding. Bleeding in turn exhibited trends towards higher inpatient death among patients with COVID-19. These findings should be interpreted with caution and larger more controlled studies are needed to verify the net effects of anticoagulation in patients with COVID-19.
    MeSH term(s) Aged ; Aged, 80 and over ; Anticoagulants/adverse effects ; COVID-19/complications ; Female ; Hemorrhage/chemically induced ; Hospital Mortality ; Humans ; Logistic Models ; Male ; Middle Aged ; Retrospective Studies ; Risk ; SARS-CoV-2
    Chemical Substances Anticoagulants
    Keywords covid19
    Language English
    Publishing date 2020-08-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2020.08.035
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  10. Article: Incidence, Risk Factors and Mortality Associated with Major Bleeding Events in Hospitalized COVID-19 Patients.

    Lucijanic, Marko / Tjesic-Drinkovic, Ida / Piskac Zivkovic, Nevenka / Pastrovic, Frane / Rob, Zrinka / Bacevac, Mersiha / Sedinic Lacko, Martina / Dzambas, Eleonora / Medic, Barbara / Vukoja, Ivan / Busic, Iva / Grgurevic, Ivica / Luksic, Ivica / Barsic, Bruno

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 8

    Abstract: ... occurrence of thrombotic events. This increases the risk of bleeding. However, data on bleeding events and ... outcomes associated with major bleeding in hospitalized COVID-19 patients. We retrospectively evaluated ... associated risk factors are scarce. Thus, we aimed to investigate the incidence, predictors and clinical ...

    Abstract Thromboprophylaxis is a mainstay of treatment of hospitalized COVID-19 patients, due to the high occurrence of thrombotic events. This increases the risk of bleeding. However, data on bleeding events and associated risk factors are scarce. Thus, we aimed to investigate the incidence, predictors and clinical outcomes associated with major bleeding in hospitalized COVID-19 patients. We retrospectively evaluated a cohort of 4014 consecutively hospitalized COVID-19 patients treated in a tertiary-level institution in the period 3/2020-3/2021. Bleeding of any kind was documented in 322 (8%) and major bleeding in 129 (3.2%) patients. A total of 129 (40.1%) bleeding events were present at the time of hospital admission, and 193 (59.9%) occurred during hospitalization. In the multivariate logistic regression analysis, intensive-care-unit treatment (adjusted odds ratio (aOR) 6.55;
    Language English
    Publishing date 2023-08-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13081699
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