Article: Interferon-induced protein Mx accumulates in nuclei of mouse cells expressing resistance to influenza viruses.
1985 Volume 140, Issue 1, Page(s) 192–196
Abstract: In mouse cells carrying the dominant influenza resistance allele Mx+ (but not in Mx- cells ... was used to demonstrate that protein Mx accumulates in the nucleus of IFN-treated Mx+ cells ... suggesting a nuclear site of action. Protein Mx is present in the nucleus of untreated influenza virus ...
| Abstract | In mouse cells carrying the dominant influenza resistance allele Mx+ (but not in Mx- cells) interferon-alpha/beta (IFN) induces an efficient antiviral state against influenza viruses and, concomitantly, the synthesis of a 75,000-Da protein (protein Mx). Here, indirect immunofluorescence using monoclonal antibodies was used to demonstrate that protein Mx accumulates in the nucleus of IFN-treated Mx+ cells, suggesting a nuclear site of action. Protein Mx is present in the nucleus of untreated influenza virus-resistant macrophages freshly explanted from the peritoneal cavity of Mx+ mice but is lost with time in culture when peritoneal macrophages become permissive for influenza virus. |
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| MeSH term(s) | Alleles ; Animals ; Antibodies, Monoclonal ; Cell Nucleus/metabolism ; Fluorescent Antibody Technique ; GTP-Binding Proteins ; Immunity, Innate ; Interferon Type I/immunology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Myxovirus Resistance Proteins ; Orthomyxoviridae/immunology ; Proteins/genetics ; Species Specificity | |||||
| Chemical Substances | Antibodies, Monoclonal ; Interferon Type I ; Mx1 protein, mouse ; Myxovirus Resistance Proteins ; Proteins ; GTP-Binding Proteins (EC 3.6.1.-) | |||||
| Language | English | |||||
| Publishing date | 1985-01-15 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 200425-2 | |||||
| ISSN | 1096-0341 ; 0042-6822 | |||||
| ISSN (online) | 1096-0341 | |||||
| ISSN | 0042-6822 | |||||
| DOI | 10.1016/0042-6822(85)90460-x | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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