LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 40

Search options

  1. Article ; Online: The

    McCoullough, Laura C / Sadauskas, Tomas / Sozzi, Vitina / Mak, Kai Yan / Mason, Hugh / Littlejohn, Margaret / Revill, Peter A

    Journal of virology

    2024  Volume 98, Issue 4, Page(s) e0153823

    Abstract: Prior to nuclear export, the hepatitis B virus (HBV) pregenomic RNA may be spliced by the host cell ... Importance: The role of hepatitis B virus (HBV) splice variants in HBV replication and pathogenesis ...

    Abstract Prior to nuclear export, the hepatitis B virus (HBV) pregenomic RNA may be spliced by the host cell spliceosome to form shorter RNA sequences known as splice variants. Due to deletions in the open reading frames, splice variants may encode novel fusion proteins. Although not essential for HBV replication, the role of splice variants and their novel fusion proteins largely remains unknown. Some splice variants and their encoded novel fusion proteins have been shown to impair or promote wild-type HBV replication
    Importance: The role of hepatitis B virus (HBV) splice variants in HBV replication and pathogenesis currently remains largely unknown. However, HBV splice variants have been associated with the development of hepatocellular carcinoma, suggesting a role in HBV pathogenesis. Several
    MeSH term(s) Humans ; DNA, Viral/genetics ; Hepatitis B/virology ; Hepatitis B virus/genetics ; Hepatitis B virus/physiology ; Liver Neoplasms ; Phenotype ; Virus Replication ; Protein Isoforms/metabolism ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Carcinoma, Hepatocellular/virology
    Chemical Substances DNA, Viral ; Protein Isoforms ; Viral Proteins
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.01538-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: The

    Ruan, Pinglang / Dai, Pei / Mao, Yu / Tang, Zhongxiang / He, Hanlin / Wu, Guojun / Qin, Ling / Tan, Yurong

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–12

    Abstract: ... respiratory syncytial virus infection. The molecular dynamics simulation analysis showed that tannic acid and daptomycin interacted ...

    Abstract The insulin-like growth factor 1 receptor (IGF1R) was recognized as a pivotal receptor that facilitated the cellular entry of RSV. Small molecule inhibitors designed to target IGF1R exhibited potential as potent antiviral agents. Through virtual screening, we conducted a screening process involving small molecule compounds derived from natural products, aiming to target the IGF1R protein against respiratory syncytial virus infection. The molecular dynamics simulation analysis showed that tannic acid and daptomycin interacted with the IGF1R. The experimental results
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2024.2309643
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: The

    Fernández-García, Leandro / Ahumada-Marchant, Constanza / Lobos-Ávila, Pablo / Brauer, Bastián / Bustos, Fernando J / Arriagada, Gloria

    Viruses

    2024  Volume 16, Issue 3

    Abstract: LTR-retrotransposons are transposable elements characterized by the presence of long terminal repeats (LTRs) directly flanking an internal coding region. They share genome organization and replication strategies with retroviruses. Steamer-like Element-1 ( ...

    Abstract LTR-retrotransposons are transposable elements characterized by the presence of long terminal repeats (LTRs) directly flanking an internal coding region. They share genome organization and replication strategies with retroviruses. Steamer-like Element-1 (
    MeSH term(s) Animals ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Internal Ribosome Entry Sites/genetics ; Retroelements/genetics ; Heterogeneous-Nuclear Ribonucleoprotein K/genetics ; Heterogeneous-Nuclear Ribonucleoprotein K/metabolism ; 5' Untranslated Regions ; Mytilus/genetics ; Mytilus/metabolism ; Protein Biosynthesis
    Chemical Substances RNA, Messenger ; Internal Ribosome Entry Sites ; Retroelements ; Heterogeneous-Nuclear Ribonucleoprotein K ; 5' Untranslated Regions
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16030403
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: The

    Barbosa, Glauce M / Morando, Maria A / Da Poian, Andrea T / Almeida, Fabio C L

    Biomolecular NMR assignments

    2023  Volume 17, Issue 1, Page(s) 23–26

    Abstract: ... in humans. It is an enveloped virus, whose genome is a positive-stranded RNA packaged by the capsid protein ... Dengue virus belongs to the Flaviviridae family, being responsible for an endemic arboviral disease ... Dengue virus capsid protein (DENVC) forms homodimers in solution organized in 4 α-helices and an intrinsically ...

    Abstract Dengue virus belongs to the Flaviviridae family, being responsible for an endemic arboviral disease in humans. It is an enveloped virus, whose genome is a positive-stranded RNA packaged by the capsid protein. Dengue virus capsid protein (DENVC) forms homodimers in solution organized in 4 α-helices and an intrinsically disordered N-terminal region. The N-terminal region is involved in the binding of membranous structures in host cells and in the recognition of nucleotides. Here we report the
    MeSH term(s) Humans ; Capsid Proteins/chemistry ; Dengue Virus/chemistry ; Dengue Virus/genetics ; Dengue Virus/metabolism ; Nuclear Magnetic Resonance, Biomolecular ; Protein Structure, Secondary ; Protein Conformation, alpha-Helical
    Chemical Substances Capsid Proteins
    Language English
    Publishing date 2023-02-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2388861-1
    ISSN 1874-270X ; 1874-2718
    ISSN (online) 1874-270X
    ISSN 1874-2718
    DOI 10.1007/s12104-022-10115-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: The

    Cubillas, Ciro / Sandoval Del Prado, Luis Enrique / Goldacker, Sydney / Fujii, Chika / Pinski, Amanda N / Zielke, Jon / Wang, David

    Journal of virology

    2023  Volume 97, Issue 4, Page(s) e0006523

    Abstract: The establishment of the Orsay virus-Caenorhabditis elegans infection model has enabled ... the identification of host factors essential for virus infection. Argonautes are RNA interacting proteins ...

    Abstract The establishment of the Orsay virus-Caenorhabditis elegans infection model has enabled the identification of host factors essential for virus infection. Argonautes are RNA interacting proteins evolutionary conserved in the three domains of life that are key components of small RNA pathways. C. elegans encodes 27 argonautes or argonaute-like proteins. Here, we determined that mutation of the argonaute-like gene 1,
    MeSH term(s) Animals ; Humans ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans/virology ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Nodaviridae/genetics ; Nodaviridae/metabolism ; RNA, Viral/genetics ; RNA, Viral/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Virus Replication/genetics ; RNA Virus Infections/virology ; Mutation
    Chemical Substances ALG-1 protein, C elegans ; Caenorhabditis elegans Proteins ; RNA, Viral ; RNA-Binding Proteins
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.00065-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: The

    Ma, Yongping / Wei, Jie / Song, Jing / Hu, Zhongxiang / Zhang, Ruifen / Li, Zhi / Sun, Yan

    Viruses

    2023  Volume 15, Issue 9

    Abstract: Foamy viruses are members of the ...

    Abstract Foamy viruses are members of the
    MeSH term(s) Promoter Regions, Genetic ; Proteolysis ; Retroviridae/genetics ; Spumavirus/physiology ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Transcriptional Activation ; Humans
    Chemical Substances Trans-Activators
    Language English
    Publishing date 2023-09-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15091899
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: The

    Yao, Roseline Assiah / Reyre, Jean-Lou / Tamburrini, Ketty C / Haon, Mireille / Tranquet, Olivier / Nalubothula, Akshay / Mukherjee, Saumashish / Le Gall, Sophie / Grisel, Sacha / Longhi, Sonia / Madhuprakash, Jogi / Bissaro, Bastien / Berrin, Jean-Guy

    Applied and environmental microbiology

    2023  Volume 89, Issue 10, Page(s) e0057323

    Abstract: ... found in bacteria and in some viruses and archaea. Interestingly, AA10-encoding genes are also ...

    Abstract Lytic polysaccharide monooxygenases (LPMOs) can perform oxidative cleavage of glycosidic bonds in carbohydrate polymers (e.g., cellulose, chitin), making them more accessible to hydrolytic enzymes. While most studies have so far mainly explored the role of LPMOs in a (plant) biomass conversion context, alternative roles and paradigms begin to emerge. The AA10 LPMOs are active on chitin and/or cellulose and mostly found in bacteria and in some viruses and archaea. Interestingly, AA10-encoding genes are also encountered in some pathogenic fungi of the Ustilaginomycetes class, such as
    MeSH term(s) Chitin/metabolism ; Polysaccharides/metabolism ; Mixed Function Oxygenases/metabolism ; Cellulose/metabolism ; Cell Wall/metabolism
    Chemical Substances Chitin (1398-61-4) ; Polysaccharides ; Mixed Function Oxygenases (EC 1.-) ; Cellulose (9004-34-6)
    Language English
    Publishing date 2023-09-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/aem.00573-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 201: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: The

    Zheng, Minghui / Li, Jing / Fang, Weizhen / Luo, Ling / Ding, Rui / Zeng, Hua / Luo, Hong / Lin, Xianghua / Duan, Chaohui

    Frontiers in immunology

    2023  Volume 14, Page(s) 1129767

    Abstract: Background: Inflammation serves as an essential driver of liver cirrhosis (LC) incidence. Accordingly, a meta-analysis was carried out to explore the association between specific polymorphisms in the interferon-γ (: Objectives: To study the ... ...

    Abstract Background: Inflammation serves as an essential driver of liver cirrhosis (LC) incidence. Accordingly, a meta-analysis was carried out to explore the association between specific polymorphisms in the interferon-γ (
    Objectives: To study the relationship between
    Methods: A database search was performed for all studies published as of September 10, 2022. The strength of risk relationships was assessed based on odds ratios (ORs) with 95% confidence intervals (CIs).
    Results: Pooled analyses were conducted for one common
    Conclusion: These findings indicate that rs361525 and rs2430561 represent LC-related risk factors, although additional large-scale clinical and case-control studies will be vital to confirm these results.
    MeSH term(s) Humans ; Fibrosis ; Genetic Predisposition to Disease ; Hepatitis B virus ; Interferon-gamma/genetics ; Liver Cirrhosis/genetics ; Polymorphism, Single Nucleotide ; Tumor Necrosis Factor-alpha/genetics
    Chemical Substances Interferon-gamma (82115-62-6) ; Tumor Necrosis Factor-alpha ; IFNG protein, human ; TNF protein, human
    Language English
    Publishing date 2023-04-14
    Publishing country Switzerland
    Document type Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1129767
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: The

    Ordaz, Norma A / Nagalakshmi, Ugrappa / Boiteux, Leonardo S / Atamian, Hagop S / Ullman, Diane E / Dinesh-Kumar, Savithramma P

    Molecular plant-microbe interactions : MPMI

    2023  Volume 36, Issue 11, Page(s) 705–715

    Abstract: The NLR (nucleotide-binding leucine-rich repeat) class immune ... ...

    Abstract The NLR (nucleotide-binding leucine-rich repeat) class immune receptor
    MeSH term(s) Animals ; Solanum lycopersicum/genetics ; Thysanoptera/genetics ; Tospovirus/physiology ; Plant Diseases ; Plant Viral Movement Proteins/metabolism ; RNA Viruses/metabolism
    Chemical Substances Plant Viral Movement Proteins
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 743331-1
    ISSN 1943-7706 ; 0894-0282
    ISSN (online) 1943-7706
    ISSN 0894-0282
    DOI 10.1094/MPMI-03-23-0032-R
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3530: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: The

    Steiert, Brianna / Icardi, Carolina M / Faris, Robert / McCaslin, Paige N / Smith, Parker / Klingelhutz, Aloysius J / Yau, Peter M / Weber, Mary M

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 20, Page(s) e2303487120

    Abstract: ... yet several pathogens, most notably oncogenic viruses, perturb this process leading to increased centrosome numbers ...

    Abstract The centrosome is the main microtubule organizing center of the cell and is crucial for mitotic spindle assembly, chromosome segregation, and cell division. Centrosome duplication is tightly controlled, yet several pathogens, most notably oncogenic viruses, perturb this process leading to increased centrosome numbers. Infection by the obligate intracellular bacterium
    MeSH term(s) Female ; Humans ; Chlamydia trachomatis ; Centrosome/metabolism ; Cell Division ; Chromosome Segregation ; Cervix Uteri ; Spindle Apparatus/metabolism
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2303487120
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top