Article ; Online: Seasonal variation of respiratory viral infections: a comparative study between children with cancer undergoing chemotherapy and children without cancer.
Pediatric hematology and oncology
2021 Volume 38, Issue 5, Page(s) 444–455
Abstract: Respiratory viral infections (RVIs) affect children year-round, with seasonal-specific patterns ... We conclude that there are differences in the seasonal patterns of RVIs between children with and ... of RVIs on cancer patients. We conducted a retrospective study of children ages 1-21 with cancer ...
| Abstract | Respiratory viral infections (RVIs) affect children year-round, with seasonal-specific patterns. Pediatric oncology patients are uniquely vulnerable to infection, but whether this predisposes them to different patterns of RVIs than healthy children is unknown. There is also limited data on the impact of RVIs on cancer patients. We conducted a retrospective study of children ages 1-21 with cancer presenting to the clinic and emergency department (ED) and a randomly selected subset of patients without cancer presenting to the ED who had positive nasopharyngeal viral polymerase chain reactions at our institution from 2014 to 2019. Sixty-seven cancer patients (206 RVI episodes) and 225 pediatric non-cancer patients (237 RVI episodes) were included. Human rhino/enterovirus (HRE) was the most common infection in both groups in the spring, summer, and fall. In the winter, the most common RVI was influenza in cancer patients verses respiratory syncytial virus in non-cancer patients. On age-adjusted analysis, the likelihood of detecting coronavirus in the winter, HRE in the spring and fall, and parainfluenza in the summer was significantly greater in cancer patients (OR = 2.60, 2.52, 5.73, 3.59 respectively). Among cancer RVI episodes, 50% received parenteral antibiotics, 22% were severely neutropenic, 22% had chemotherapy delays for a median of six days, 16% were hospitalized, and 6% received intravenous immunoglobulin. We conclude that there are differences in the seasonal patterns of RVIs between children with and without cancer. RVIs also cause significant morbidity in children with cancer. |
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| MeSH term(s) | Adolescent ; Adult ; Anti-Bacterial Agents/therapeutic use ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Child ; Child, Preschool ; Coronavirus/isolation & purification ; Enterovirus/isolation & purification ; Female ; Hospitalization/statistics & numerical data ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Infant ; Influenza, Human/epidemiology ; Male ; Neoplasms/drug therapy ; Neoplasms/epidemiology ; Neoplasms/virology ; Neutropenia/epidemiology ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/virology ; Retrospective Studies ; Rhinovirus/isolation & purification ; Seasons ; Virus Diseases/epidemiology ; Young Adult | |||||
| Chemical Substances | Anti-Bacterial Agents ; Antineoplastic Agents ; Immunoglobulins, Intravenous | |||||
| Language | English | |||||
| Publishing date | 2021-04-01 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 632914-7 | |||||
| ISSN | 1521-0669 ; 0888-0018 | |||||
| ISSN (online) | 1521-0669 | |||||
| ISSN | 0888-0018 | |||||
| DOI | 10.1080/08880018.2020.1871137 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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