Article ; Online: GM1 ganglioside antibody and COVID-19 related Guillain Barre Syndrome - A case report, systemic review and implication for vaccine development.
Brain, behavior, & immunity - health
2021 Volume 12, Page(s) 100203
Abstract: ... for possible vaccine induced complication. Whether the current GM1 positive case is a sequalae of COVID-19 or ... Background: Guillain Barre Syndrome (GBS) and Miller Fisher Syndrome (MFS) are emerging as known ... consequences of COVID-19 infection. However, there have been no reported cases with positive GM1 or GQ1b ...
| Abstract | Background: Guillain Barre Syndrome (GBS) and Miller Fisher Syndrome (MFS) are emerging as known consequences of COVID-19 infection. However, there have been no reported cases with positive GM1 or GQ1b antibodies in the literature to date. Although clinically similar, the pathophysiology of COVID-19 related GBS and MFS may be significantly different from cases in the pre-pandemic era. Case presentation: We present a patient with ascending areflexic weakness consistent with GBS with positive GM1 antibody. The patient had recovered from COVID-19 infection two weeks prior with mild viral illness and symptoms. Her weakness was isolated to the lower extremities and improved after intravenous immunoglobulin treatment. Patient recovered eventually. Conclusions: - The general lack of reported ganglioside antibodies supports a novel target(s) for molecular mimicry as the underlying etiology, which raises the concern for possible vaccine induced complication. Whether the current GM1 positive case is a sequalae of COVID-19 or a mere coincidence is inconclusive. Further understanding of the disease mechanism of pandemic era GBS and MFS, including antigen target(s) of COVID-19, may be of utmost importance to the development of a safe COVID-19 vaccine. |
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| Language | English |
| Publishing date | 2021-01-13 |
| Publishing country | United States |
| Document type | Case Reports |
| ISSN | 2666-3546 |
| ISSN (online) | 2666-3546 |
| DOI | 10.1016/j.bbih.2021.100203 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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