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  1. Article ; Online: Association of contact to small children with a mild course of COVID-19.

    Dugas, Martin / Schrempf, Inga-Marie / Ochs, Kevin / Frömmel, Christopher / Greulich, Leonard / Neuhaus, Philipp / Tepasse, Phil-Robin / Schmidt, Hartmut H-J

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2020  Volume 100, Page(s) 314–315

    Abstract: ... and regular contact with small children also may have a mild course of COVID-19 more frequently ... It is known that severe COVID-19 cases in small children are rare. If a childhood-related infection ... were protective against a severe course of COVID-19, it would be expected that adults with intensive ...

    Abstract It is known that severe COVID-19 cases in small children are rare. If a childhood-related infection were protective against a severe course of COVID-19, it would be expected that adults with intensive and regular contact with small children also may have a mild course of COVID-19 more frequently. To test this hypothesis, a survey among 4010 recovered COVID-19 patients was conducted in Germany. 1186 complete answers were collected. 6.9% of these patients reported frequent and regular job-related contact with children below ten years of age, and 23.2% had their own small children, which was higher than expected. In the relatively small subgroup with intensive care treatment (n = 19), patients without contact with small children were overrepresented. These findings are not well explained by age, gender, or BMI distribution of those patients and should be validated in other settings.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; COVID-19/immunology ; COVID-19/transmission ; Child ; Cohort Studies ; Contact Tracing ; Critical Care ; Family Health ; Female ; Germany ; Humans ; Male ; Middle Aged ; Patient Acuity ; SARS-CoV-2 ; Surveys and Questionnaires ; Treatment Outcome ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-09-05
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2020.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Association of contact to small children with a mild course of COVID-19

    Dugas, Martin / Schrempf, Inga-Marie / Ochs, Kevin / Frömmel, Christopher / Greulich, Leonard / Neuhaus, Philipp / Tepasse, Phil-Robin / Schmidt, Hartmut H-J

    Int J Infect Dis

    Abstract: ... and regular contact with small children also may have a mild course of COVID-19 more frequently ... It is known that severe COVID-19 cases in small children are rare. If a childhood-related infection ... were protective against a severe course of COVID-19, it would be expected that adults with intensive ...

    Abstract It is known that severe COVID-19 cases in small children are rare. If a childhood-related infection were protective against a severe course of COVID-19, it would be expected that adults with intensive and regular contact with small children also may have a mild course of COVID-19 more frequently. To test this hypothesis, a survey among 4010 recovered COVID-19 patients was conducted in Germany. 1186 complete answers were collected. 6.9% of these patients reported frequent and regular job-related contact with children below ten years of age, and 23.2% had their own small children, which was higher than expected. In the relatively small subgroup with intensive care treatment (n = 19), patients without contact with small children were overrepresented. These findings are not well explained by age, gender, or BMI distribution of those patients and should be validated in other settings.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #747509
    Database COVID19

    Kategorien

  3. Article ; Online: Association of contact to small children with mild course of COVID-19

    Dugas, M. / Schrempf, I. M. / Ochs, K. / Froemmel, C. / Greulich, L. / Neuhaus, P. / Tepasse, P.-R. / Schmidt, H. H.

    Abstract: ... and regular contact to small children also may have a mild course of COVID-19 more frequently. To test ... It is known that severe COVID-19 cases in small children are rare. If a childhood-related infection ... small subgroup with intensive care treatment (n=19), patients without contact to small children were ...

    Abstract It is known that severe COVID-19 cases in small children are rare. If a childhood-related infection would be protective against severe course of COVID-19, it would be expected that adults with intensive and regular contact to small children also may have a mild course of COVID-19 more frequently. To test this hypothesis, a survey among 4,010 recovered COVID-19 patients was conducted in Germany. 1,186 complete answers were collected. 6.9% of these patients reported frequent and regular job-related contact to children below 10 years of age and 23.2% had own small children, which is higher than expected. In the relatively small subgroup with intensive care treatment (n=19), patients without contact to small children were overrepresented. These findings are not well explained by age, gender or BMI distribution of those patients and should be validated in other settings.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    DOI 10.1101/2020.07.20.20157149
    Database COVID19

    Kategorien

  4. Article ; Online: Association of contact to small children with mild course of COVID-19

    Dugas, Martin / Schrempf, Inga Marie / Ochs, Kevin / Froemmel, Christopher / Greulich, Leonard / Neuhaus, Philipp / Tepasse, Phil-Robin / Schmidt, Hartmut HJ

    medRxiv

    Abstract: ... and regular contact to small children also may have a mild course of COVID-19 more frequently. To test ... It is known that severe COVID-19 cases in small children are rare. If a childhood-related infection ... small subgroup with intensive care treatment (n=19), patients without contact to small children were ...

    Abstract It is known that severe COVID-19 cases in small children are rare. If a childhood-related infection would be protective against severe course of COVID-19, it would be expected that adults with intensive and regular contact to small children also may have a mild course of COVID-19 more frequently. To test this hypothesis, a survey among 4,010 recovered COVID-19 patients was conducted in Germany. 1,186 complete answers were collected. 6.9% of these patients reported frequent and regular job-related contact to children below 10 years of age and 23.2% had own small children, which is higher than expected. In the relatively small subgroup with intensive care treatment (n=19), patients without contact to small children were overrepresented. These findings are not well explained by age, gender or BMI distribution of those patients and should be validated in other settings.
    Keywords covid19
    Language English
    Publishing date 2020-07-26
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.07.20.20157149
    Database COVID19

    Kategorien

  5. Article ; Online: Association of contact to small children with a mild course of COVID-19

    Martin Dugas / Inga-Marie Schrempf / Kevin Ochs / Christopher Frömmel / Leonard Greulich / Philipp Neuhaus / Phil-Robin Tepasse / Hartmut H.-J. Schmidt

    International Journal of Infectious Diseases, Vol 100, Iss , Pp 314-

    2020  Volume 315

    Abstract: ... and regular contact with small children also may have a mild course of COVID-19 more frequently ... It is known that severe COVID-19 cases in small children are rare. If a childhood-related infection ... were protective against a severe course of COVID-19, it would be expected that adults with intensive ...

    Abstract It is known that severe COVID-19 cases in small children are rare. If a childhood-related infection were protective against a severe course of COVID-19, it would be expected that adults with intensive and regular contact with small children also may have a mild course of COVID-19 more frequently. To test this hypothesis, a survey among 4010 recovered COVID-19 patients was conducted in Germany. 1186 complete answers were collected. 6.9% of these patients reported frequent and regular job-related contact with children below ten years of age, and 23.2% had their own small children, which was higher than expected. In the relatively small subgroup with intensive care treatment (n = 19), patients without contact with small children were overrepresented. These findings are not well explained by age, gender, or BMI distribution of those patients and should be validated in other settings.
    Keywords Infectious and parasitic diseases ; RC109-216 ; covid19
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Association of contact to small children with a mild course of COVID-19

    Dugas, Martin / Schrempf, Inga-Marie / Ochs, Kevin / Frömmel, Christopher / Greulich, Leonard / Neuhaus, Philipp / Tepasse, Phil-Robin / Schmidt, Hartmut H.-J.

    International Journal of Infectious Diseases

    2020  Volume 100, Page(s) 314–315

    Keywords Microbiology (medical) ; Infectious Diseases ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2020.09.003
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  7. Article ; Online: Less severe course of COVID-19 is associated with elevated levels of antibodies against seasonal human coronaviruses OC43 and HKU1 (HCoV OC43, HCoV HKU1)

    Dugas, Martin / Grote-Westrick, Tanja / Vollenberg, Richard / Lorentzen, Eva / Brix, Tobias / Schmidt, Hartmut / Tepasse, Phil-Robin / Kuehn, Joachim

    medRxiv

    Abstract: ... rate of fatalities. Recently, an association between contact to small children and mild course of COVID ... The clinical course of COVID-19 is very heterogeneous: Most infected individuals can be managed ... with seasonal coronaviruses on COVID-19 severity. 60 patients with confirmed COVID-19 infections were included ...

    Abstract The clinical course of COVID-19 is very heterogeneous: Most infected individuals can be managed in an outpatient setting, but a substantial proportion of patients requires intensive care, resulting in a high rate of fatalities. Recently, an association between contact to small children and mild course of COVID-19 was reported. We performed an observational study to assess the impact of previous infections with seasonal coronaviruses on COVID-19 severity. 60 patients with confirmed COVID-19 infections were included (age 30 - 82 years; 52 males, 8 females): 19 inpatients with critical disease, 16 inpatients with severe or moderate disease and 25 outpatients (age and gender matched to inpatients). Patients with critical disease had significantly lower levels of HCoV OC43- (p=0.016) and HCoV HKU1-specific (p=0.023) antibodies at the first encounter compared to other COVID-19 patients. Our results indicate that previous infections with seasonal coronaviruses might protect against a severe course of disease. This finding should be validated in other settings and could contribute to identify persons at risk before an infection.
    Keywords covid19
    Language English
    Publishing date 2020-10-14
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.10.12.20211599
    Database COVID19

    Kategorien

  8. Article ; Online: Less severe course of COVID-19 is associated with elevated levels of antibodies against seasonal human coronaviruses OC43 and HKU1 (HCoV OC43, HCoV HKU1)

    Dugas, M. / Grote-Westrick, T. / Vollenberg, R. / Lorentzen, E. / Brix, T. / Schmidt, H. / Tepasse, P.-R. / Kuehn, J.

    Abstract: ... rate of fatalities. Recently, an association between contact to small children and mild course of COVID ... The clinical course of COVID-19 is very heterogeneous: Most infected individuals can be managed ... with seasonal coronaviruses on COVID-19 severity. 60 patients with confirmed COVID-19 infections were included ...

    Abstract The clinical course of COVID-19 is very heterogeneous: Most infected individuals can be managed in an outpatient setting, but a substantial proportion of patients requires intensive care, resulting in a high rate of fatalities. Recently, an association between contact to small children and mild course of COVID-19 was reported. We performed an observational study to assess the impact of previous infections with seasonal coronaviruses on COVID-19 severity. 60 patients with confirmed COVID-19 infections were included (age 30 - 82 years; 52 males, 8 females): 19 inpatients with critical disease, 16 inpatients with severe or moderate disease and 25 outpatients (age and gender matched to inpatients). Patients with critical disease had significantly lower levels of HCoV OC43- (p=0.016) and HCoV HKU1-specific (p=0.023) antibodies at the first encounter compared to other COVID-19 patients. Our results indicate that previous infections with seasonal coronaviruses might protect against a severe course of disease. This finding should be validated in other settings and could contribute to identify persons at risk before an infection.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    DOI 10.1101/2020.10.12.20211599
    Database COVID19

    Kategorien

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