Article ; Online: Increased resistance to fibrinolysis activation in patients with coronavirus disease 2019: a case series.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
2021 Volume 32, Issue 4, Page(s) 298–301
Abstract: We describe seven critically ill and seven noncritically ill patients with coronavirus disease 2019 ... hypercoagulability with increased resistance to fibrinolysis, reflected by tissue plasminogen activator test ... Our pathological observations show that the hypercoagulative status described in these patients is, at least ...
| Abstract | We describe seven critically ill and seven noncritically ill patients with coronavirus disease 2019 infection. Two viscoelastic assays were performed with ClotPro technology, activated by extrinsic system test and recombinant tissue plasminogen activator challenge test. Coagulation profile presents a marked hypercoagulability with increased resistance to fibrinolysis, reflected by tissue plasminogen activator test. Our pathological observations show that the hypercoagulative status described in these patients is, at least partially, secondary to fibrinolysis shutdown. |
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| MeSH term(s) | Adult ; Aged ; Blood Cell Count ; Blood Coagulation Tests ; COVID-19/blood ; COVID-19/complications ; Comorbidity ; Critical Illness ; Disease Progression ; Female ; Fibrinolysis ; Hemorrhage/epidemiology ; Hemorrhage/etiology ; Hospital Mortality ; Hospitals, Urban ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Patients' Rooms ; Recombinant Proteins ; SARS-CoV-2 ; Spain/epidemiology ; Thromboembolism/epidemiology ; Thromboembolism/etiology ; Thrombophilia/blood ; Thrombophilia/etiology ; Tissue Plasminogen Activator | |||||
| Chemical Substances | Recombinant Proteins ; Tissue Plasminogen Activator (EC 3.4.21.68) | |||||
| Language | English | |||||
| Publishing date | 2021-01-25 | |||||
| Publishing country | England | |||||
| Document type | Comparative Study ; Journal Article | |||||
| ZDB-ID | 1033551-1 | |||||
| ISSN | 1473-5733 ; 0957-5235 | |||||
| ISSN (online) | 1473-5733 | |||||
| ISSN | 0957-5235 | |||||
| DOI | 10.1097/MBC.0000000000001017 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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