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  1. TI=Transmission dynamics are crucial to COVID 19 vaccination policy
  2. TI=Interferon dysregulation and virus induced cell death in avian influenza H5N1 virus infections

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  1. Article ; Online: Transmission dynamics are crucial to COVID-19 vaccination policy.

    Dushoff, Jonathan / Colijn, Caroline / Earn, David J D / Bolker, Benjamin M

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 29

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; Policy ; SARS-CoV-2 ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-06-30
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2105878118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Transmission of SARS-CoV-2 by Children.

    Merckx, Joanna / Labrecque, Jeremy A / Kaufman, Jay S

    Deutsches Arzteblatt international

    2020  Volume 117, Issue 33-34, Page(s) 553–560

    Abstract: ... the different study designs and considerations necessary for valid assessment of transmission dynamics ... methodology through 25 June, 2020.: Results: Transmission dynamics must be studied in repre - sentative ... Background: Six months into the COVID-19 pandemic, children appear largely spared from the direct ...

    Abstract Background: Six months into the COVID-19 pandemic, children appear largely spared from the direct effects of disease, suggesting age as an important predictor of infection and severity. They remain, however, impacted by far-reaching public health interventions. One crucial question often posed is whether children generally transmit SARS-CoV-2 effectively.
    Methods: We assessed the components of transmission and the different study designs and considerations necessary for valid assessment of transmission dynamics. We searched for published evidence about transmission of SARS-CoV-2 by children employing a narrative review methodology through 25 June, 2020.
    Results: Transmission dynamics must be studied in repre - sentative pediatric populations with a combination of study designs including rigorous epidemiological studies (e.g. in households, schools, daycares, clinical settings) and laboratory studies while taking into account the social and socio-economic contexts. Viral load (VL) estimates from representative pediatric samples of infected children are missing so far. Currently available evidence suggests that the secondary attack rate stratified by age of the infector is lower for children, however this age pattern needs to be better quantified and understood.
    Conclusion: A generalizable pediatric evidence base is urgently needed to inform policy making now, later when facing potential subsequent waves, and extending through a future in which endemicity alongside vaccination may become the enduring reality.
    MeSH term(s) COVID-19 ; Child ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission
    Keywords covid19
    Language English
    Publishing date 2020-07-24
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.2020.0553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: COVID-19 transmission dynamics and the impact of vaccination: modelling, analysis and simulations.

    Malinzi, Joseph / Juma, Victor Ogesa / Madubueze, Chinwendu Emilian / Mwaonanji, John / Nkem, Godwin Nwachukwu / Mwakilama, Elias / Mupedza, Tinashe Victor / Chiteri, Vincent Nandwa / Bakare, Emmanuel Afolabi / Moyo, Isabel Linda-Zulu / Campillo-Funollet, Eduard / Nyabadza, Farai / Madzvamuse, Anotida

    Royal Society open science

    2023  Volume 10, Issue 7, Page(s) 221656

    Abstract: ... its potential trends amidst variations in COVID-19 vaccine coverage is therefore crucial for policy ... challenge including the sub-Saharan Africa (SSA) region. Knowledge of the COVID-19 dynamics and ... Despite the lifting of COVID-19 restrictions, the COVID-19 pandemic and its effects remain a global ...

    Abstract Despite the lifting of COVID-19 restrictions, the COVID-19 pandemic and its effects remain a global challenge including the sub-Saharan Africa (SSA) region. Knowledge of the COVID-19 dynamics and its potential trends amidst variations in COVID-19 vaccine coverage is therefore crucial for policy makers in the SSA region where vaccine uptake is generally lower than in high-income countries. Using a compartmental epidemiological model, this study aims to forecast the potential COVID-19 trends and determine how long a wave could be, taking into consideration the current vaccination rates. The model is calibrated using South African reported data for the first four waves of COVID-19, and the data for the fifth wave are used to test the validity of the model forecast. The model is qualitatively analysed by determining equilibria and their stability, calculating the basic reproduction number
    Language English
    Publishing date 2023-07-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.221656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Transmission of SARS-CoV-2 by Children

    Merckx, Joanna / Labrecque, Jeremy A / Kaufman, Jay S

    Dtsch Arztebl Int

    Abstract: ... the different study designs and considerations necessary for valid assessment of transmission dynamics ... methodology through 25 June, 2020. RESULTS: Transmission dynamics must be studied in repre - sentative ... BACKGROUND: Six months into the COVID-19 pandemic, children appear largely spared from the direct ...

    Abstract BACKGROUND: Six months into the COVID-19 pandemic, children appear largely spared from the direct effects of disease, suggesting age as an important predictor of infection and severity. They remain, however, impacted by far-reaching public health interventions. One crucial question often posed is whether children generally transmit SARS-CoV-2 effectively. METHODS: We assessed the components of transmission and the different study designs and considerations necessary for valid assessment of transmission dynamics. We searched for published evidence about transmission of SARS-CoV-2 by children employing a narrative review methodology through 25 June, 2020. RESULTS: Transmission dynamics must be studied in repre - sentative pediatric populations with a combination of study designs including rigorous epidemiological studies (e.g. in households, schools, daycares, clinical settings) and laboratory studies while taking into account the social and socio-economic contexts. Viral load (VL) estimates from representative pediatric samples of infected children are missing so far. Currently available evidence suggests that the secondary attack rate stratified by age of the infector is lower for children, however this age pattern needs to be better quantified and understood. CONCLUSION: A generalizable pediatric evidence base is urgently needed to inform policy making now, later when facing potential subsequent waves, and extending through a future in which endemicity alongside vaccination may become the enduring reality.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #676459
    Database COVID19

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