Article ; Online: Effect of verapamil and lidocaine on TRPM and NaV1.9 gene expressions in renal ischemia-reperfusion.
2014 Volume 46, Issue 1, Page(s) 33–39
Abstract: ... significantly reduce the degree of ischemia-reperfusion injury due to effects to TRPM and Nav1.9 genes. ... and NaV1.9 genes were evaluated in kidney tissues after induced ischemia-reperfusion.: Material and ... Results: When compared to ischemia group expression levels of TRPM2, TRPM4, TRPM6, and NaV1.9 in Ca(2+ ...
| Abstract | Background: To determine effects on calcium and sodium channels of Ca(2+) and Na(+) channel blockers in the present study, expression levels of TRPM1, TRPM2, TRPM3, TRPM4, TRPM5, TRPM6, TRPM7, TRPM8, and NaV1.9 genes were evaluated in kidney tissues after induced ischemia-reperfusion. Material and methods: Forty albino Wistar male rats were equally divided into 4 groups as follows: group I: control group (n = 10), group II: ischemia group (60 minutes of ischemia + 48 hours of reperfusion; n = 10), group III: ischemia (60 minutes of ischemia + 48 hours of reperfusion) + calcium channel blocker (n = 8), group IV: ischemia (60 minutes of ischemia + 48 hours of reperfusion) + sodium channel blocker (n = 8). Results: When compared to ischemia group expression levels of TRPM2, TRPM4, TRPM6, and NaV1.9 in Ca(2+) and Na(+) channel blocker groups were increased, whereas that of TRPM7 was decreased. However, expression levels of TRPM1, TRPM3, TRPM5, and TRPM8 were not determined in kidney tissue. Histologically, the Ca(2+) channel blocker verapamil and the Na(+) channel blocker lidocaine inhibited the cell death in kidney tissue compared to control. Conclusion: Our study suggested that verapamil and lidocaine significantly reduce the degree of ischemia-reperfusion injury due to effects to TRPM and Nav1.9 genes. |
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| MeSH term(s) | Animals ; Calcium Channel Blockers/administration & dosage ; Calcium Channels/metabolism ; Disease Models, Animal ; Gene Expression Regulation ; Kidney/pathology ; Kidney Diseases/drug therapy ; Kidney Diseases/pathology ; Lidocaine/administration & dosage ; Male ; NAV1.9 Voltage-Gated Sodium Channel/metabolism ; Rats ; Rats, Wistar ; Reperfusion Injury/drug therapy ; TRPM Cation Channels/metabolism ; Verapamil/administration & dosage ; Voltage-Gated Sodium Channel Blockers/administration & dosage | |||||
| Chemical Substances | Calcium Channel Blockers ; Calcium Channels ; NAV1.9 Voltage-Gated Sodium Channel ; Scn11a protein, rat ; TRPM Cation Channels ; Voltage-Gated Sodium Channel Blockers ; Lidocaine (98PI200987) ; Verapamil (CJ0O37KU29) | |||||
| Language | English | |||||
| Publishing date | 2014-01 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 82046-5 | |||||
| ISSN | 1873-2623 ; 0041-1345 | |||||
| ISSN (online) | 1873-2623 | |||||
| ISSN | 0041-1345 | |||||
| DOI | 10.1016/j.transproceed.2013.10.036 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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