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  1. Article ; Online: Origin, Evolution, and Loss of Bacterial Small RNAs.

    Dutcher, H Auguste / Raghavan, Rahul

    Microbiology spectrum

    2018  Volume 6, Issue 2

    Abstract: Despite the central role of bacterial noncoding small RNAs (sRNAs) in posttranscriptional ... neofunctionalization, to their loss from bacterial lineages. Because they possess relatively unrestrictive structural ... regulation, little is understood about their evolution. Here we compile what has been studied to date and ...

    Abstract Despite the central role of bacterial noncoding small RNAs (sRNAs) in posttranscriptional regulation, little is understood about their evolution. Here we compile what has been studied to date and trace a life cycle of sRNAs-from their mechanisms of emergence, through processes of change and frequent neofunctionalization, to their loss from bacterial lineages. Because they possess relatively unrestrictive structural requirements, we find that sRNA origins are varied, and include
    MeSH term(s) Bacteria/genetics ; Bacteria/metabolism ; Binding Sites ; Evolution, Molecular ; Gene Expression Regulation, Bacterial ; Gene Transfer, Horizontal/genetics ; Genome, Bacterial/genetics ; MicroRNAs/genetics ; MicroRNAs/physiology ; Molecular Sequence Annotation ; Mutation ; Phylogeny ; Protein Binding ; RNA, Bacterial/genetics ; RNA, Bacterial/physiology ; RNA, Small Untranslated/genetics ; RNA, Small Untranslated/physiology ; Sigma Factor
    Chemical Substances MicroRNAs ; RNA, Bacterial ; RNA, Small Untranslated ; Sigma Factor
    Language English
    Publishing date 2018-04-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 2165-0497
    ISSN (online) 2165-0497
    DOI 10.1128/microbiolspec.RWR-0004-2017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A recent evolutionary origin of a bacterial small RNA that controls multicellular fruiting body development.

    Chen, I-Chen Kimberly / Griesenauer, Brad / Yu, Yuen-Tsu Nicco / Velicer, Gregory J

    Molecular phylogenetics and evolution

    2014  Volume 73, Page(s) 1–9

    Abstract: In animals and plants, non-coding small RNAs regulate the expression of many genes at the post ... about the phylogenetic or mechanistic origins of such bacterial sRNAs. Here we propose a phylogenetic origin ... transcriptional level. Recently, many non-coding small RNAs (sRNAs) have also been found to regulate a variety ...

    Abstract In animals and plants, non-coding small RNAs regulate the expression of many genes at the post-transcriptional level. Recently, many non-coding small RNAs (sRNAs) have also been found to regulate a variety of important biological processes in bacteria, including social traits, but little is known about the phylogenetic or mechanistic origins of such bacterial sRNAs. Here we propose a phylogenetic origin of the myxobacterial sRNA Pxr, which negatively regulates the initiation of fruiting body development in Myxococcus xanthus as a function of nutrient level, and also examine its diversification within the Myxococcocales order. Homologs of pxr were found throughout the Cystobacterineae suborder (with a few possible losses) but not outside this clade, suggesting a single origin of the Pxr regulatory system in the basal Cystobacterineae lineage. Rates of pxr sequence evolution varied greatly across Cystobacterineae sub-clades in a manner not predicted by overall genome divergence. A single copy of pxr was found in most species with 17% of nucleotide positions being polymorphic among them. However three tandem paralogs were present within the genus Cystobacter and these alleles together exhibited an elevated rate of divergence. There appears to have been strong selection for maintenance of a predicted stem-loop structure, as polymorphisms accumulated preferentially at loop or bulge regions or as complementary substitutions within predicted stems. All detected pxr homologs are located in the intergenic region between the σ(54)-dependent response regulator nla19 and a predicted NADH dehydrogenase gene, but other neighboring gene content has diversified.
    MeSH term(s) Alleles ; Base Sequence ; Evolution, Molecular ; Genetic Variation/genetics ; Molecular Sequence Data ; Myxococcus xanthus/classification ; Myxococcus xanthus/genetics ; Myxococcus xanthus/physiology ; Nucleic Acid Conformation ; Phylogeny ; RNA, Bacterial/chemistry ; RNA, Bacterial/genetics ; RNA, Small Untranslated/chemistry ; RNA, Small Untranslated/genetics ; Spores, Bacterial/genetics ; Spores, Bacterial/growth & development
    Chemical Substances RNA, Bacterial ; RNA, Small Untranslated
    Language English
    Publishing date 2014-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 33610-5
    ISSN 1095-9513 ; 1055-7903
    ISSN (online) 1095-9513
    ISSN 1055-7903
    DOI 10.1016/j.ympev.2014.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A recent evolutionary origin of a bacterial small RNA that controls multicellular fruiting body development

    Chen, I-Chen Kimberly / Brad Griesenauer / Gregory J. Velicer / Yuen-Tsu Nicco Yu

    Molecular phylogenetics and evolution. 2014 Apr., v. 73

    2014  

    Abstract: In animals and plants, non-coding small RNAs regulate the expression of many genes at the post ... about the phylogenetic or mechanistic origins of such bacterial sRNAs. Here we propose a phylogenetic origin ... transcriptional level. Recently, many non-coding small RNAs (sRNAs) have also been found to regulate a variety ...

    Abstract In animals and plants, non-coding small RNAs regulate the expression of many genes at the post-transcriptional level. Recently, many non-coding small RNAs (sRNAs) have also been found to regulate a variety of important biological processes in bacteria, including social traits, but little is known about the phylogenetic or mechanistic origins of such bacterial sRNAs. Here we propose a phylogenetic origin of the myxobacterial sRNA Pxr, which negatively regulates the initiation of fruiting body development in Myxococcus xanthus as a function of nutrient level, and also examine its diversification within the Myxococcocales order. Homologs of pxr were found throughout the Cystobacterineae suborder (with a few possible losses) but not outside this clade, suggesting a single origin of the Pxr regulatory system in the basal Cystobacterineae lineage. Rates of pxr sequence evolution varied greatly across Cystobacterineae sub-clades in a manner not predicted by overall genome divergence. A single copy of pxr was found in most species with 17% of nucleotide positions being polymorphic among them. However three tandem paralogs were present within the genus Cystobacter and these alleles together exhibited an elevated rate of divergence. There appears to have been strong selection for maintenance of a predicted stem-loop structure, as polymorphisms accumulated preferentially at loop or bulge regions or as complementary substitutions within predicted stems. All detected pxr homologs are located in the intergenic region between the σ54-dependent response regulator nla19 and a predicted NADH dehydrogenase gene, but other neighboring gene content has diversified.
    Keywords alleles ; animals ; bacteria ; Cystobacter ; fruiting bodies ; intergenic DNA ; Myxococcus xanthus ; NADH dehydrogenase ; nutrient content ; phylogeny ; plants (botany) ; RNA ; stems
    Language English
    Dates of publication 2014-04
    Size p. 1-9.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 33610-5
    ISSN 1095-9513 ; 1055-7903
    ISSN (online) 1095-9513
    ISSN 1055-7903
    DOI 10.1016/j.ympev.2014.01.001
    Database NAL-Catalogue (AGRICOLA)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3644: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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