Article ; Online: SARS-CoV-2 and Male Infertility: Possible Multifaceted Pathology.
Reproductive sciences (Thousand Oaks, Calif.)
2020 Volume 28, Issue 1, Page(s) 23–26
Abstract: ... Thus, it is crucial to determine whether SARS-CoV-2 infection can even affect male fertility as an immediate ... The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the coronavirus disease ... that angiotensin converting enzymes 2 (ACE2) receptor, that aids the SARS-CoV-2 entry into host cells, is ...
| Abstract | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the coronavirus disease 2019 (COVID-19) has been declared a pandemic by the World Health Organization (WHO) on 11th March 2020. Bulk of research on this virus are carried out to unveil its multivariate pathology. Surprisingly, men are reportedly more vulnerable to COVID-19 even with higher fatality rate compared to women. Thus, it is crucial to determine whether SARS-CoV-2 infection can even affect male fertility as an immediate or long-term consequence of the disease. Among the discrete data available, an important finding is that angiotensin converting enzymes 2 (ACE2) receptor, that aids the SARS-CoV-2 entry into host cells, is profoundly expressed in testicular cells. In addition, the endogenous androgen milieu and its receptors are associated with ACE2 activation reflecting that enhanced testosterone levels may trigger the pathogenesis of COVID-19. In contrary, hypogonadism has also been reported in the acute phase of some COVID-19 cases. Moreover, SARS-CoV-2 infection-induced uncontrolled inflammatory responses may lead to systemic oxidative stress (OS), whose severe disruptive effects on testicular functions are well-documented. This article aims to precisely present the possible impact of COVID-19 on male reproductive functions, and to highlight the speculations that need in-depth research for the exact underlying mechanisms how COVID-19 is associated with men's health and fertility. |
|---|---|
| MeSH term(s) | Angiotensin-Converting Enzyme 2/metabolism ; COVID-19/epidemiology ; COVID-19/metabolism ; COVID-19/pathology ; Humans ; Infertility, Male/epidemiology ; Infertility, Male/metabolism ; Infertility, Male/pathology ; Male ; SARS-CoV-2/metabolism ; Testis/metabolism ; Testis/pathology |
| Chemical Substances | ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-07-10 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ZDB-ID | 2276411-2 |
| ISSN | 1933-7205 ; 1933-7191 |
| ISSN (online) | 1933-7205 |
| ISSN | 1933-7191 |
| DOI | 10.1007/s43032-020-00261-z |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 4113: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.