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  1. TI=Delayed diagnosis and treatment of children with cancer during the COVID 19 pandemic
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  1. Article ; Online: Delayed diagnosis and treatment of children with cancer during the COVID-19 pandemic.

    Dvori, Michal / Elitzur, Sarah / Barg, Assaf / Barzilai-Birenboim, Shlomit / Gilad, Gil / Amar, Shirah / Toledano, Helen / Toren, Amos / Weinreb, Sigal / Goldstein, Gal / Shapira, Adi / Ash, Shifra / Izraeli, Shai / Gilad, Oded

    International journal of clinical oncology

    2021  Volume 26, Issue 8, Page(s) 1569–1574

    Abstract: ... Conclusion: Fear from the COVID-19 pandemic may result in delayed diagnosis and treatment of children ... treatment of children with cancer have been less described.: Methods: A survey was performed in the four ... guidelines). Delays also resulted from co-infection with COVID-19 and the attribution of the oncologic ...

    Abstract Background: COVID-19, the novel coronavirus has caused a global pandemic affecting millions of people around the world. Although children, including children with cancer, have been found to be affected less commonly and less severely than adults, indirect effects of the pandemic on the diagnosis and treatment of children with cancer have been less described.
    Methods: A survey was performed in the four largest tertiary pediatric hematology-oncology medical centers in Israel. Clinical and laboratory data were collected from the medical files of patients diagnosed or treated with cancer during April-October 2020.
    Results: Seventeen patients are described, who had a significant delay in diagnosis or treatment of cancer. These represent approximately 10% of all pediatric cancer diagnosed during the study period in these centers. A main cause of delay was fear of exposure to COVID-19 (fears felt by the patient, parent, physician, or decision-makers at the institution; or the implementation of national guidelines). Delays also resulted from co-infection with COVID-19 and the attribution of the oncologic symptoms to the infection. In addition, treatment was delayed of patients already diagnosed with cancer, due to COVID-19 infection detected in the patient, a family member, or a bone marrow donor.
    Conclusion: Fear from the COVID-19 pandemic may result in delayed diagnosis and treatment of children with cancer, which may carry a risk to dismal prognosis. It is crucial that pediatricians and patients alike remember that other diseases still prevail and must be thought of and treated in a timely fashion.
    Language English
    Publishing date 2021-06-18
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1400227-9
    ISSN 1437-7772 ; 1341-9625
    ISSN (online) 1437-7772
    ISSN 1341-9625
    DOI 10.1007/s10147-021-01971-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4828: Show issues Location:
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  2. Article ; Online: Health Economic Consequences Associated With COVID-19-Related Delay in Melanoma Diagnosis in Europe.

    Maul, Lara V / Jamiolkowski, Dagmar / Lapides, Rebecca A / Mueller, Alina M / Hauschild, Axel / Garbe, Claus / Lorigan, Paul / Gershenwald, Jeffrey E / Ascierto, Paolo Antonio / Long, Georgina V / Wang-Evers, Michael / Scolyer, Richard A / Saravi, Babak / Augustin, Matthias / Navarini, Alexander A / Legge, Stefan / Németh, István B / Jánosi, Ágnes J / Mocellin, Simone /
    Feller, Anita / Manstein, Dieter / Zink, Alexander / Maul, Julia-Tatjana / Buja, Alessandra / Adhikari, Kaustubh / Roider, Elisabeth

    JAMA network open

    2024  Volume 7, Issue 2, Page(s) e2356479

    Abstract: ... outcomes were the total burden of a delay in melanoma diagnosis during COVID-19 lockdown periods, measured ... associated with suspended melanoma screenings during COVID-19 pandemic lockdowns by estimating the total ... Importance: The COVID-19 pandemic resulted in delayed access to medical care. Restrictions ...

    Abstract Importance: The COVID-19 pandemic resulted in delayed access to medical care. Restrictions to health care specialists, staff shortages, and fear of SARS-CoV-2 infection led to interruptions in routine care, such as early melanoma detection; however, premature mortality and economic burden associated with this postponement have not been studied yet.
    Objective: To determine the premature mortality and economic costs associated with suspended melanoma screenings during COVID-19 pandemic lockdowns by estimating the total burden of delayed melanoma diagnoses for Europe.
    Design, setting, and participants: This multicenter economic evaluation used population-based data from patients aged at least 18 years with invasive primary cutaneous melanomas stages I to IV according to the American Joint Committee on Cancer (AJCC) seventh and eighth editions, including melanomas of unknown primary (T0). Data were collected from January 2017 to December 2021 in Switzerland and from January 2019 to December 2021 in Hungary. Data were used to develop an estimation of melanoma upstaging rates in AJCC stages, which was verified with peripandemic data. Years of life lost (YLL) were calculated and were, together with cost data, used for financial estimations. The total financial burden was assessed through direct and indirect treatment costs. Models were building using data from 50 072 patients aged 18 years and older with invasive primary cutaneous melanomas stages I to IV according to the AJCC seventh and eighth edition, including melanomas of unknown primary (T0) from 2 European tertiary centers. Data from European cancer registries included patient-based direct and indirect cost data, country-level economic indicators, melanoma incidence, and population rates per country. Data were analyzed from July 2021 to September 2022.
    Exposure: COVID-19 lockdown-related delay of melanoma detection and consecutive public health and economic burden. As lockdown restrictions varied by country, lockdown scenario was defined as elimination of routine medical examinations and severely restricted access to follow-up examinations for at least 4 weeks.
    Main outcomes and measures: Primary outcomes were the total burden of a delay in melanoma diagnosis during COVID-19 lockdown periods, measured using the direct (in US$) and indirect (calculated as YLL plus years lost due to disability [YLD] and disability-adjusted life-years [DALYs]) costs for Europe. Secondary outcomes included estimation of upstaging rate, estimated YLD, YLL, and DALY for each European country, absolute direct and indirect treatment costs per European country, proportion of the relative direct and indirect treatment costs for the countries, and European health expenditure.
    Results: There were an estimated 111 464 (range, 52 454-295 051) YLL due to pandemic-associated delay in melanoma diagnosis in Europe, and estimated total additional costs were $7.65 (range, $3.60 to $20.25) billion. Indirect treatment costs were the main cost driver, accounting for 94.5% of total costs. Estimates for YLD in Europe resulted in 15 360 years for the 17% upstaging model, ranging from 7228 years (8% upstaging model) to 40 660 years (45% upstaging model). Together, YLL and YLD constitute the overall disease burden, ranging from 59 682 DALYs (8% upstaging model) to 335 711 DALYs (45% upstaging model), with 126 824 DALYs for the real-world 17% scenario.
    Conclusions and relevance: This economic analysis emphasizes the importance of continuing secondary skin cancer prevention measures during pandemics. Beyond the personal outcomes of a delayed melanoma diagnosis, the additional economic and public health consequences are underscored, emphasizing the need to include indirect economic costs in future decision-making processes. These estimates on DALYs and the associated financial losses complement previous studies highlighting the cost-effectiveness of screening for melanoma.
    MeSH term(s) Humans ; Adolescent ; Adult ; Melanoma/diagnosis ; Melanoma/epidemiology ; Pandemics ; Neoplasms, Unknown Primary/epidemiology ; COVID-19/diagnosis ; COVID-19/epidemiology ; SARS-CoV-2 ; Communicable Disease Control ; Europe/epidemiology ; Cost of Illness ; Skin Neoplasms/diagnosis ; Skin Neoplasms/epidemiology ; COVID-19 Testing
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.56479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Treatment delay and treatment pattern modifications among epithelial ovarian cancer patients during the COVID-19 pandemic: A retrospective cohort study.

    Moterani, Vinicius Cesar / Moterani, Nino Jose Wilson / Candido Dos Reis, Francisco Jose

    Journal of surgical oncology

    2022  Volume 126, Issue 7, Page(s) 1155–1161

    Abstract: ... diagnosed during the first 22 months of the COVID-19 pandemic in the state of Sao Paulo and those diagnosed ... access and medical treatment, including oncological care. Treatment delay in ovarian cancer could impact ... Background and objectives: The coronavirus disease 2019 (COVID-19) pandemic disrupted healthcare ...

    Abstract Background and objectives: The coronavirus disease 2019 (COVID-19) pandemic disrupted healthcare access and medical treatment, including oncological care. Treatment delay in ovarian cancer could impact survival. We aimed to assess if there were delays and treatment changes in a cohort of epithelial ovarian cancer patients.
    Methods: A retrospective cohort of epithelial ovarian cancer patients included cases diagnosed during the first 22 months of the COVID-19 pandemic in the state of Sao Paulo and those diagnosed in the 22 months preceding the outbreak. Time-to-treat was measured in days. In each group, surgery and chemotherapy proportions were assessed according to healthcare insurance status.
    Results: A 56.2% reduction in epithelial ovarian cancer diagnosis was identified during the pandemic group compared to the prepandemic group; fewer patients were diagnosed in stage I (p < 0.01). Time-to-treat increased from 18.9 to 23 days (p < 0.01). Surgery in the public sector fell from 74.6% to 65.3% during the pandemic, compared to 87.1% to 68.8% in the private sector.
    Conclusion: There were fewer overall diagnoses, reduced stage I diagnosis, increased time-to-treat, and a reduction in the proportion of patients submitted to surgery. Brazil's public healthcare system demonstrated a higher resiliency to treatment change than the private sector.
    MeSH term(s) Humans ; Female ; Pandemics ; COVID-19/epidemiology ; Carcinoma, Ovarian Epithelial/therapy ; Retrospective Studies ; Time-to-Treatment ; Brazil/epidemiology ; Ovarian Neoplasms/therapy ; Ovarian Neoplasms/drug therapy ; Cohort Studies
    Language English
    Publishing date 2022-08-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82063-5
    ISSN 1096-9098 ; 0022-4790
    ISSN (online) 1096-9098
    ISSN 0022-4790
    DOI 10.1002/jso.27048
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 706: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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  4. Article ; Online: Effect of COVID-19 Pandemic on Diagnosis and Treatment Delays in Urological Disease

    Li Z / Jiang Y / Yu Y / Kang Q

    Risk Management and Healthcare Policy, Vol Volume 14, Pp 895-

    Single-Institution Experience

    2021  Volume 900

    Abstract: ... 19 on diagnosis and treatment delay in urology patients.Patients and Methods: A total of 4919 ... treatment with unfavorable consequences.Conclusion: With the impact of COVID-19, delay in diagnosis or ... treatment of non-COVID-19 diseases is inevitable whether the medical resources ... ...

    Abstract Zhen Li,1,* Yu Jiang,2,* Yang Yu,3,* Qianyu Kang3,* 1Department of Urology, The Fifth People’s Hospital of Dalian, Dalian, Liaoning, People’s Republic of China; 2Department of Pediatrics, Dalian Municipal Women and Children’s Medical Center, Dalian, Liaoning, People’s Republic of China; 3Department of Urology, The Second Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qianyu Kang; Yang YuDepartment of Urology, The Second Hospital of Dalian Medical University, 467 Zhongshan Road, Shahekou District, Dalian, Liaoning, 116023, People’s Republic of ChinaTel +86-180-1895-0098; +86-180-9887-7887Email m18840827901@163.com; 450988941@qq.comPurpose: In the background of the global pandemic, we aim to investigate the effect of COVID-19 on diagnosis and treatment delay in urology patients.Patients and Methods: A total of 4919 inpatients were identified from the urological department in our institution, including 2947 and 1972 patients within 9 months before and after the outbreak (group A and group B). The baseline characteristics and residential population of different types of diseases were compared in the two groups. Patients who underwent delay of diagnosis or treatment with poor outcomes were described.Results: Our result revealed a 33.1% decrease of total resident population as well as a 44.8% decline in bed utilization rate after the outbreak. Significant differences were found between group A and group B in gender (P=0.024) and patients living alone or not (P=0.026). The hospitalization rate of patients with malignancy increased significantly while that of benign patients decreased during the epidemic (P< 0.001). Besides, we identified 5 cases with bladder cancer and 3 cases with prostate cancer that underwent delay of diagnosis or treatment with unfavorable consequences.Conclusion: With the impact of COVID-19, delay in diagnosis or treatment of non-COVID-19 diseases is inevitable whether the medical resources ...
    Keywords covid-19 ; benign disease ; prostate cancer ; bladder cancer ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Dove Medical Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Letter to the Editor

    Klaus Rose / Oishi Tanjinatus / Jane Grant-Kels / Earl B. Ettienne / Pasquale Striano

    Rambam Maimonides Medical Journal, Vol 12, Iss 3, p e

    Delayed Presentation of Non-COVID-19 Patients During the COVID-19 Pandemic Is Not Limited to Children

    2021  Volume 0026

    Abstract: ... Several recent papers discuss delays of diagnosis and treatment of non-COVID-19 diseases during the pandemic ... diseases during the COVID-19 pandemic. We would like to emphasize that, firstly, such delays are not ... some are adults, and appendicitis is discussed in both. The delay the COVID-19 pandemic has caused ...

    Abstract We read with interest the report about four minors who were diagnosed late with non-COVID-19 diseases during the COVID-19 pandemic. We would like to emphasize that, firstly, such delays are not limited to minors, and secondly, that also in minors should we distinguish the administrative and the physiological meanings of the term “child” and hence distinguish administratively defined “children” who bodily are already mature from those young patients who bodily are indeed still children. The 16-year-old patient that was presented to the emergency room with endocarditis was bodily no longer a child, although administratively and probably also psychologically, due to his Down syndrome, he was still a child. Two of the other patients, one with hemolytic anemia (2.5 years old) and one with Ewing sarcoma (4 years old), were still pre-pubertal children, while the 13-year-old minor with a septic hip was already adolescent. The author of the cited paper works in a pediatric department and reports those patients that he has seen during his work. However, in our view there is nothing specifically pediatric in his observations. Several recent papers discuss delays of diagnosis and treatment of non-COVID-19 diseases during the pandemic, including head and neck cancer, appendicitis, heart failure and septicemia, pulmonary thromboembolism, pyelonephritis, and cancer in general. Some patients in these papers are administratively still “children,” some are adults, and appendicitis is discussed in both. The delay the COVID-19 pandemic has caused in the timely diagnosis of various diseases is not a “pediatric” challenge, but a challenge for medicine in general.
    Keywords covid-19 pandemic ; multiple inflammatory syndrome (mis) ; multiple inflammatory syndrome in children (mis-c) ; pediatric drug development ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Rambam Health Care Campus
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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