Article: Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation.
2005 Volume 47, Issue 2, Page(s) 233–240
Abstract: Protein farnesylation is a form of posttranslational modification that occurs in most, if not ... the targeting of protein farnesyltransferase for the treatment of parasitic diseases. ... all, eukaryotic cells. Inhibitors of protein farnesyltransferase (PFTIs) have been developed as anticancer ...
| Abstract | Protein farnesylation is a form of posttranslational modification that occurs in most, if not all, eukaryotic cells. Inhibitors of protein farnesyltransferase (PFTIs) have been developed as anticancer chemotherapeutic agents. Using the knowledge gained from the development of PFTIs for the treatment of cancer, researchers are currently investigating the use of PFTIs for the treatment of eukaryotic pathogens. This "piggy-back" approach not only accelerates the development of a chemotherapeutic agent for protozoan pathogens but is also a means of mitigating the costs associated with de novo drug design. PFTIs have already been shown to be efficacious in the treatment of eukaryotic pathogens in animal models, including both Trypanosoma brucei, the causative agent of African sleeping sickness, and Plasmodium falciparum, one of the causative agents of malaria. Here, current evidence and progress are summarized that support the targeting of protein farnesyltransferase for the treatment of parasitic diseases. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Animals ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Eukaryota/drug effects ; Eukaryota/metabolism ; Farnesyltranstransferase/antagonists & inhibitors ; Farnesyltranstransferase/metabolism ; Humans ; Molecular Structure ; Parasitic Diseases/drug therapy ; Parasitic Diseases/parasitology ; Protein Prenylation/drug effects ; Protozoan Infections/drug therapy ; Protozoan Infections/parasitology | |||||
| Chemical Substances | Enzyme Inhibitors ; Farnesyltranstransferase (EC 2.5.1.29) | |||||
| Language | English | |||||
| Publishing date | 2005-12-07 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review | |||||
| ZDB-ID | 80154-9 | |||||
| ISSN | 1539-7262 ; 0022-2275 | |||||
| ISSN (online) | 1539-7262 | |||||
| ISSN | 0022-2275 | |||||
| DOI | 10.1194/jlr.R500016-JLR200 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 175: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.