Article ; Online: Anti-HCV, nucleotide inhibitors, repurposing against COVID-19.
2020 Volume 248, Page(s) 117477
Abstract: ... to test anti-HCV drugs against COVID-19 RNA dependent RNA polymerase (RdRp).: Materials and methods ... other countries. Human to human transmission is confirmed for COVID-19 by China a month ago. Based ... In this study, sequence analysis, modeling, and docking are used to build a model for Wuhan COVID-19 RdRp ...
| Abstract | Aims: A newly emerged Human Coronavirus (HCoV) is reported two months ago in Wuhan, China (COVID-19). Until today >2700 deaths from the 80,000 confirmed cases reported mainly in China and 40 other countries. Human to human transmission is confirmed for COVID-19 by China a month ago. Based on the World Health Organization (WHO) reports, SARS HCoV is responsible for >8000 cases with confirmed 774 deaths. Additionally, MERS HCoV is responsible for 858 deaths out of about 2500 reported cases. The current study aims to test anti-HCV drugs against COVID-19 RNA dependent RNA polymerase (RdRp). Materials and methods: In this study, sequence analysis, modeling, and docking are used to build a model for Wuhan COVID-19 RdRp. Additionally, the newly emerged Wuhan HCoV RdRp model is targeted by anti-polymerase drugs, including the approved drugs Sofosbuvir and Ribavirin. Key findings: The results suggest the effectiveness of Sofosbuvir, IDX-184, Ribavirin, and Remidisvir as potent drugs against the newly emerged HCoV disease. Significance: The present study presents a perfect model for COVID-19 RdRp enabling its testing in silico against anti-polymerase drugs. Besides, the study presents some drugs that previously proved its efficiency against the newly emerged viral infection. |
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| MeSH term(s) | Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/chemistry ; Adenosine Monophosphate/metabolism ; Alanine/analogs & derivatives ; Alanine/chemistry ; Alanine/metabolism ; Alphacoronavirus/enzymology ; Alphacoronavirus/genetics ; Amino Acid Sequence ; Antiviral Agents/chemistry ; Antiviral Agents/metabolism ; Betacoronavirus/enzymology ; Betacoronavirus/genetics ; COVID-19 ; Catalytic Domain ; Computational Biology/methods ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Drug Repositioning/methods ; Guanosine Monophosphate/analogs & derivatives ; Guanosine Monophosphate/chemistry ; Guanosine Monophosphate/metabolism ; Guanosine Triphosphate/chemistry ; Guanosine Triphosphate/metabolism ; Humans ; Molecular Docking Simulation ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; RNA-Dependent RNA Polymerase/antagonists & inhibitors ; RNA-Dependent RNA Polymerase/chemistry ; RNA-Dependent RNA Polymerase/metabolism ; Ribavirin/chemistry ; Ribavirin/metabolism ; SARS-CoV-2 ; Sequence Alignment ; Sequence Homology, Amino Acid ; Sofosbuvir/chemistry ; Sofosbuvir/metabolism ; Thermodynamics ; Uridine Triphosphate/chemistry ; Uridine Triphosphate/metabolism ; Viral Proteins/antagonists & inhibitors ; Viral Proteins/chemistry ; Viral Proteins/metabolism |
| Chemical Substances | Antiviral Agents ; IDX184 ; Viral Proteins ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Ribavirin (49717AWG6K) ; Guanosine Monophosphate (85-32-5) ; Guanosine Triphosphate (86-01-1) ; RNA-Dependent RNA Polymerase (EC 2.7.7.48) ; Alanine (OF5P57N2ZX) ; Uridine Triphosphate (UT0S826Z60) ; Sofosbuvir (WJ6CA3ZU8B) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-02-28 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 3378-9 |
| ISSN | 1879-0631 ; 0024-3205 |
| ISSN (online) | 1879-0631 |
| ISSN | 0024-3205 |
| DOI | 10.1016/j.lfs.2020.117477 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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