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  1. Article: Inflammatory Myofibroblastic Tumor of the Liver: A Diagnostic Challenge.

    Elpek, Gülsüm Özlem

    Journal of clinical and translational hepatology

    2014  Volume 2, Issue 1, Page(s) 53–57

    Abstract: Inflammatory myofibroblastic tumor (IMT) is an uncommon myofibroblastic neoplasm that was formerly ... of liver tumors, especially in patients with tumor markers in normal range. ... of the liver is a distinctive neoplasm of intermediate biological potential, and should be distinguished ...

    Abstract Inflammatory myofibroblastic tumor (IMT) is an uncommon myofibroblastic neoplasm that was formerly included within the broad category of inflammatory pseudotumor (IPT). IMT is rarely encountered in the liver. Similar to IMT of other organs, the interchangeable use of the terms IMT and IPT in liver has made the analysis of these lesions difficult. In this review, clinical and pathological features of IMT of the liver are reviewed and the differential diagnosis of IMT is discussed, with emphasis on IPT and the other entities included in this large category. IMT can mimic malignant tumors. There are no known unique diagnostic clinical, laboratory, or radiological features. The definitive diagnosis of IMT depends on careful pathological examination. The histopathological evaluation of hepatic IMT reveals that, the myxoid/vascular pattern is the most frequently observed, followed by, in decreasing frequency, fibrous histiocytoma-like pattern and hypocellular fibrous pattern. In IMT of the liver, anaplastic lymphoma kinase (ALK) expression reliably predicts the presence of an ALK gene rearrangement. The diagnosis of hepatic IMT depends on the dominant histopathological pattern, and the management of the disease is still controversial. IMT of the liver is a distinctive neoplasm of intermediate biological potential, and should be distinguished from the variety of lesions that are included under the broad category of IPT. Therefore, to avoid confusion regarding the true incidence and behavior of hepatic IMT, the term IPT should not be used interchangeably with IMT. The rarity of IMT in liver should not minimize its consideration in the differential diagnosis of liver tumors, especially in patients with tumor markers in normal range.
    Language English
    Publishing date 2014-03-15
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 3019822-7
    ISSN 2310-8819 ; 2225-0719
    ISSN (online) 2310-8819
    ISSN 2225-0719
    DOI 10.14218/JCTH.2013.00023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Complicated course of biliary inflammatory myofibroblastic tumor mimicking hilar cholangiocarcinoma: A case report and literature review.

    Strainiene, Sandra / Sedleckaite, Kotryna / Jarasunas, Juozas / Savlan, Ilona / Stanaitis, Juozas / Stundiene, Ieva / Strainys, Tomas / Liakina, Valentina / Valantinas, Jonas

    World journal of clinical cases

    2021  Volume 9, Issue 21, Page(s) 6155–6169

    Abstract: Background: The inflammatory myofibroblastic tumor (IMT) is a rare, idiopathic, usually benign ... diagnostic and clinical challenge as it is indistinguishable from cholangiocarcinoma, and there are no ... diagnostic laparoscopy with liver and lymph node biopsies). Histological examination revealed signs of IMT ...

    Abstract Background: The inflammatory myofibroblastic tumor (IMT) is a rare, idiopathic, usually benign, mass-forming disease with myofibroblastic proliferation and a varying amount of inflammatory cells. Although it can affect various organs, the biliary tract is a rare localization of primary IMT, clinically, endoscopically and radiologically imitating cholangiocarcinoma. The treatment options are based only on clinical practice experience.
    Case summary: A 70-year-old woman was referred to our center due to progressive fatigue, weight loss, abdominal pain, night sweats, and elevated liver enzymes. Magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography (ERCP) revealed proximal common hepatic duct and hilar biliary strictures extending bilaterally to lobular bile ducts. Although initial clinical, endoscopic and radiological signs were typical for hilar cholangiocarcinoma, histological examination showed no signs of malignancy. In total, 8 biopsies using different approaches were performed (several biopsies from dominant stricture during ERCP and direct cholangioscopy; ultrasound-guided liver biopsy; diagnostic laparoscopy with liver and lymph node biopsies). Histological examination revealed signs of IMT, and the final diagnosis of biliary IMT was stated. Although IMT is usually a benign disease, in our case, it was complicated. All pharmacological treatment measures were ineffective. The patient still needs permanent stenting, suffers from recurrent infections and mechanical jaundice. Despite that, the patient already survived 24 mo.
    Conclusion: IMT presenting with hilar biliary strictures is a unique diagnostic and clinical challenge as it is indistinguishable from cholangiocarcinoma, and there are no evidence-based treatment options. Our goal is to increase the understanding of this rare disease and its possible course.
    Language English
    Publishing date 2021-07-21
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v9.i21.6155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Inflammatory Myofibroblastic Tumor of the Liver: Challenges in the Preoperative Diagnosis and Treatment.

    Liu, Fei / Hu, Hai-Jie / Wang, Jun-Ke / Li, Fu-Yu

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

    2017  Volume 22, Issue 6, Page(s) 1132–1133

    MeSH term(s) Female ; Hepatectomy ; Humans ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Magnetic Resonance Imaging ; Middle Aged ; Neoplasms, Muscle Tissue/diagnostic imaging ; Neoplasms, Muscle Tissue/pathology ; Neoplasms, Muscle Tissue/surgery
    Language English
    Publishing date 2017-12-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2012365-6
    ISSN 1873-4626 ; 1934-3213 ; 1091-255X
    ISSN (online) 1873-4626 ; 1934-3213
    ISSN 1091-255X
    DOI 10.1007/s11605-017-3637-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 354: Show issues

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  4. Article ; Online: Extrapulmonary inflammatory myofibroblastic tumor with synchronous involvement of the liver and appendix

    Manickam Neethirajan Saravanan / Kota Venugopal / Balbir Singh

    Clinical Cancer Investigation Journal, Vol 5, Iss 2, Pp 175-

    2016  Volume 177

    Abstract: Inflammatory myofibroblastic tumor (IMT) of the liver is a rare disease, often confused ... both the liver and appendix. We present the diagnostic challenge and approach in a patient with IMT of the liver ... with hepatic neoplasm. A 60-year-old man underwent liver resection for suspected hepatocellular carcinoma ...

    Abstract Inflammatory myofibroblastic tumor (IMT) of the liver is a rare disease, often confused with hepatic neoplasm. A 60-year-old man underwent liver resection for suspected hepatocellular carcinoma with concurrent appendicectomy for incidentally detected diseased appendix. Histopathology revealed IMT involving both the liver and appendix. We present the diagnostic challenge and approach in a patient with IMT of the liver with the synchronous incidental involvement of appendix treated successfully by liver resection and appendicectomy.
    Keywords Appendix ; inflammatory myofibroblastic tumor ; liver ; Medicine ; R ; Internal medicine ; RC31-1245 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Publishing date 2016-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Cytology of fine-needle aspiration of inflammatory myofibroblastic tumor.

    Stoll, Lisa Marie / Li, Qing Kay

    Diagnostic cytopathology

    2011  Volume 39, Issue 9, Page(s) 663–672

    Abstract: Inflammatory Myofibroblastic Tumor (IMT) is a rare spindle cell neoplasm with a relatively indolent ... years old with a median age of 54 years. The locations of the tumor in descending order were: liver (9 ... the majority of tumors consisted of bland spindle cells with oval nuclei and small prominent nucleoli ...

    Abstract Inflammatory Myofibroblastic Tumor (IMT) is a rare spindle cell neoplasm with a relatively indolent course. Its morphology may be confused with both reactive processes and/or malignant neoplasms on FNA specimens. Herein we discuss the cytologic features and IHC studies of IMT. The archives of the Department of Pathology at the Johns Hopkins Hospital were searched for IMT. A total of 257 cases were identified over a period of 11 years. Among them, 20 cases had cytology material. The patients' ages ranged from 7 to 81 years old with a median age of 54 years. The locations of the tumor in descending order were: liver (9/20, 45%), lung (8/20, 40%), abdomen (1/20, 5%), pelvis (1/20, 5%), and kidney (1/20, 5%). On FNA, the majority of tumors consisted of bland spindle cells with oval nuclei and small prominent nucleoli in a background of lymphocytes and plasma cells. Focal cytological atypia and "ganglion-like" cells were identified in 7 cases, likely related to the risk of metastases and malignant transformation. The lesional cells expressed ALK (8/17, 47.1%) and actin (10/10, 100%), but with variable expression of cytokeratin. Ki-67 showed low proliferative indices. ALK gene rearrangement was detected by FISH in three out of three cases and correlated with ALK protein expression by IHC. The cytologic diagnosis of IMT is challenging. When encountering a spindle cell lesion with prominent inflammatory component, a high index of suspicion in combination with the use of ancillary studies increases the diagnostic yield of IMT.
    MeSH term(s) Abdominal Neoplasms/diagnosis ; Abdominal Neoplasms/metabolism ; Abdominal Neoplasms/pathology ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/metabolism ; Biopsy, Fine-Needle ; Cell Nucleus/pathology ; Cell Shape ; Child ; Female ; Humans ; Inflammation/diagnosis ; Inflammation/metabolism ; Inflammation/pathology ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/metabolism ; Kidney Neoplasms/pathology ; Liver Neoplasms/diagnosis ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Lung Neoplasms/diagnosis ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Myofibroma/diagnosis ; Myofibroma/metabolism ; Myofibroma/pathology ; Pelvic Neoplasms/diagnosis ; Pelvic Neoplasms/metabolism ; Pelvic Neoplasms/pathology ; Receptor Protein-Tyrosine Kinases/metabolism
    Chemical Substances Biomarkers, Tumor ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; anaplastic lymphoma kinase (EC 2.7.10.1)
    Language English
    Publishing date 2011-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632710-2
    ISSN 1097-0339 ; 8755-1039
    ISSN (online) 1097-0339
    ISSN 8755-1039
    DOI 10.1002/dc.21444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2117: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Inflammatory myofibroblastic tumor of the liver mimicking an infiltrative malignancy in computed tomography and magnetic resonance imaging with Gd-EOB.

    Durmus, Tahir / Kamphues, Carsten / Blaeker, Hendrik / Grieser, Christian / Denecke, Timm

    Acta radiologica short reports

    2014  Volume 3, Issue 7, Page(s) 2047981614544404

    Abstract: ... them from malignant liver tumors and local recurrent growth may occur. IMT is a diagnostic challenge for imaging. Only ... Inflammatory myofibroblastic tumors (IMT) are a benign tumor entity, which rarely develop ... in the liver. Surgery is the most common treatment for these lesions as it is difficult to distinguish ...

    Abstract Inflammatory myofibroblastic tumors (IMT) are a benign tumor entity, which rarely develop in the liver. Surgery is the most common treatment for these lesions as it is difficult to distinguish them from malignant liver tumors and local recurrent growth may occur. IMT is a diagnostic challenge for imaging. Only a limited number of reports of single cases or small number of patients described the imaging features on computed tomography. Reports on IMT appearance on magnetic resonance imaging are scarce. We present a case of IMT of the liver with infiltration of the abdominal wall treated with surgery and describe the imaging features with the use of the hepatobiliary contrast agent, gadoxetic acid (Gd-EOB).
    Language English
    Publishing date 2014-08-22
    Publishing country England
    Document type Case Reports
    ZDB-ID 2649745-1
    ISSN 2047-9816
    ISSN 2047-9816
    DOI 10.1177/2047981614544404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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