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  1. Article: Histopathological Study of Cyclosporine Pulmonary Toxicity in Rats.

    Elshama, Said Said / El-Kenawy, Ayman El-Meghawry / Osman, Hosam-Eldin Hussein

    Journal of toxicology

    2016  Volume 2016, Page(s) 2973274

    Abstract: ... of cyclosporine in rats by assessment of pulmonary histopathological changes using light and electron microscope ... on the vital organs such as lung are still few. This study aims to investigate pulmonary toxic effect ... around alveoli with negative Periodic Acid-Schiff staining. Prolonged use of cyclosporine induced pulmonary ...

    Abstract Cyclosporine is considered one of the common worldwide immunosuppressive drugs that are used for allograft rejection prevention. However, articles that address adverse effects of cyclosporine use on the vital organs such as lung are still few. This study aims to investigate pulmonary toxic effect of cyclosporine in rats by assessment of pulmonary histopathological changes using light and electron microscope examination. Sixty male adult albino rats were divided into three groups; each group consists of twenty rats. The first received physiological saline while the second and third groups received 25 and 40 mg/kg/day of cyclosporine, respectively, by gastric gavage for forty-five days. Cyclosporine reduced the lung and body weight with shrinkage or pyknotic nucleus of pneumocyte type II, degeneration of alveoli and interalveolar septum beside microvilli on the alveolar surface, emphysema, inflammatory cellular infiltration, pulmonary blood vessels congestion, and increase of fibrous tissues in the interstitial tissues and around alveoli with negative Periodic Acid-Schiff staining. Prolonged use of cyclosporine induced pulmonary ultrastructural and histopathological changes with the lung and body weight reduction depending on its dose.
    Language English
    Publishing date 2016-01-28
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2495098-1
    ISSN 1687-8205 ; 1687-8191
    ISSN (online) 1687-8205
    ISSN 1687-8191
    DOI 10.1155/2016/2973274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Long-term cyclosporine treatment: evaluation of serum biochemical parameters and histopathological alterations in Wistar rats.

    Böhmer, Ana Elisa / Mendes Ribeiro Corrêa, André / de Souza, Débora Guerini / Knorr, Luisa / Hansel, Gisele / Corbellini, Luís Gustavo / Driemeier, David / Portela, Luis Valmor / Souza, Diogo Onofre

    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie

    2011  Volume 63, Issue 1-2, Page(s) 119–123

    Abstract: ... and cytokines levels, kidney and liver functionality, as well as lung histopathological status in rats ... in rats without causing nephro and hepatotoxicity. ... to other drug therapies. In the present study, we assessed for direct associations between CsA immunosuppressive therapy ...

    Abstract The immunosuppressant agent cyclosporine (CsA) is currently used in transplanted patients and in the therapy of autoimmune disorders. CsA treatment has significant acute and chronic side effects on the liver and kidney. However, in the clinical setting, it is difficult to distinguish a direct effect of CsA treatment from other confounding variables, such as allograft rejection and effects due to other drug therapies. In the present study, we assessed for direct associations between CsA immunosuppressive therapy and cytokines levels, kidney and liver functionality, as well as lung histopathological status in rats submitted to chronic CsA treatment without undergoing any transplantation. Male Wistar rats were divided into three groups. The control group received vehicle (corn oil), and treated groups received CsA 5 or 15 mg/kg, by daily gastric gavage during 8 weeks. The results demonstrated that CsA treatment decreases blood levels of interleukins 1α (IL-1α), 1β (IL-1β) and interleukin 2 (IL-2), but does not alter interleukin 6 (IL-6) and IFN-γ levels. Serum biochemical markers of renal (creatinine) and hepatic (SGPT and SGOT) injury/dysfunction did not vary with CsA treatment, despite the presence of small histological alterations, suggesting that the function of these metabolic organs were preserved. Pulmonary histopathological lesions were observed in the CsA groups, and they were attributed to the activation of the local immunoresponse mechanisms by the normal microbiota in immunosuppressive CsA cases. These results suggest that the CsA concentrations administered in our experimental protocol were able to induce immunosuppression in rats without causing nephro and hepatotoxicity.
    MeSH term(s) Animals ; Cyclosporine/adverse effects ; Cyclosporine/blood ; Cytokines/blood ; Cytokines/immunology ; Dose-Response Relationship, Drug ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/blood ; Kidney/drug effects ; Kidney/pathology ; Kidney Function Tests ; Liver/drug effects ; Liver/pathology ; Liver Function Tests ; Lung/drug effects ; Lung/pathology ; Male ; Rats ; Rats, Wistar ; Time Factors
    Chemical Substances Cytokines ; Immunosuppressive Agents ; Cyclosporine (83HN0GTJ6D)
    Language English
    Publishing date 2011-01
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1107321-4
    ISSN 1618-1433 ; 0940-2993
    ISSN (online) 1618-1433
    ISSN 0940-2993
    DOI 10.1016/j.etp.2009.10.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 455: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Long-term cyclosporine treatment: Evaluation of serum biochemical parameters and histopathological alterations in Wistar rats

    Elisa Böhmer, Ana / Ribeiro Corrêa, André Mendes / de Souza, Débora Guerini / Knorr, Luisa / Hansel, Gisele / Gustavo Corbellini, Luís / Driemeier, David / Valmor Portela, Luis / Onofre Souza, Diogo

    Experimental and toxicologic pathology. 2011 Jan., v. 63, no. 1-2

    2011  

    Abstract: ... and cytokines levels, kidney and liver functionality, as well as lung histopathological status in rats ... in rats without causing nephro and hepatotoxicity. ... to other drug therapies. In the present study, we assessed for direct associations between CsA immunosuppressive therapy ...

    Abstract The immunosuppressant agent cyclosporine (CsA) is currently used in transplanted patients and in the therapy of autoimmune disorders. CsA treatment has significant acute and chronic side effects on the liver and kidney. However, in the clinical setting, it is difficult to distinguish a direct effect of CsA treatment from other confounding variables, such as allograft rejection and effects due to other drug therapies. In the present study, we assessed for direct associations between CsA immunosuppressive therapy and cytokines levels, kidney and liver functionality, as well as lung histopathological status in rats submitted to chronic CsA treatment without undergoing any transplantation. Male Wistar rats were divided into three groups. The control group received vehicle (corn oil), and treated groups received CsA 5 or 15mg/kg, by daily gastric gavage during 8 weeks. The results demonstrated that CsA treatment decreases blood levels of interleukins 1α (IL-1α), 1β (IL-1β) and interleukin 2 (IL-2), but does not alter interleukin 6 (IL-6) and IFN-γ levels. Serum biochemical markers of renal (creatinine) and hepatic (SGPT and SGOT) injury/dysfunction did not vary with CsA treatment, despite the presence of small histological alterations, suggesting that the function of these metabolic organs were preserved. Pulmonary histopathological lesions were observed in the CsA groups, and they were attributed to the activation of the local immunoresponse mechanisms by the normal microbiota in immunosuppressive CsA cases. These results suggest that the CsA concentrations administered in our experimental protocol were able to induce immunosuppression in rats without causing nephro and hepatotoxicity.
    Keywords adverse effects ; biomarkers ; blood chemistry ; blood serum ; corn oil ; creatinine ; cyclosporine ; graft rejection ; hepatotoxicity ; histopathology ; interferon-gamma ; interleukin-1alpha ; interleukin-1beta ; interleukin-2 ; interleukin-6 ; kidneys ; liver ; patients ; rats ; therapeutics
    Language English
    Dates of publication 2011-01
    Size p. 119-123.
    Publishing place Elsevier GmbH
    Document type Article
    ZDB-ID 1107321-4
    ISSN 1618-1433 ; 0940-2993
    ISSN (online) 1618-1433
    ISSN 0940-2993
    DOI 10.1016/j.etp.2009.10.005
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 69/123: Show issues

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  4. Article: Long-term cyclosporine treatment: Evaluation of serum biochemical parameters and histopathological alterations in Wistar rats

    Elisa Böhmer, Ana / Ribeiro Corrêa, André Mendes / de Souza, Débora Guerini / Knorr, Luisa / Hansel, Gisele / Gustavo Corbellini, Luís / Driemeier, David / Valmor Portela, Luis / Onofre Souza, Diogo

    Experimental and toxicologic pathology

    Volume v. 63,, Issue no. 1

    Abstract: ... and cytokines levels, kidney and liver functionality, as well as lung histopathological status in rats ... in rats without causing nephro and hepatotoxicity. ... to other drug therapies. In the present study, we assessed for direct associations between CsA immunosuppressive therapy ...

    Abstract The immunosuppressant agent cyclosporine (CsA) is currently used in transplanted patients and in the therapy of autoimmune disorders. CsA treatment has significant acute and chronic side effects on the liver and kidney. However, in the clinical setting, it is difficult to distinguish a direct effect of CsA treatment from other confounding variables, such as allograft rejection and effects due to other drug therapies. In the present study, we assessed for direct associations between CsA immunosuppressive therapy and cytokines levels, kidney and liver functionality, as well as lung histopathological status in rats submitted to chronic CsA treatment without undergoing any transplantation. Male Wistar rats were divided into three groups. The control group received vehicle (corn oil), and treated groups received CsA 5 or 15mg/kg, by daily gastric gavage during 8 weeks. The results demonstrated that CsA treatment decreases blood levels of interleukins 1α (IL-1α), 1β (IL-1β) and interleukin 2 (IL-2), but does not alter interleukin 6 (IL-6) and IFN-γ levels. Serum biochemical markers of renal (creatinine) and hepatic (SGPT and SGOT) injury/dysfunction did not vary with CsA treatment, despite the presence of small histological alterations, suggesting that the function of these metabolic organs were preserved. Pulmonary histopathological lesions were observed in the CsA groups, and they were attributed to the activation of the local immunoresponse mechanisms by the normal microbiota in immunosuppressive CsA cases. These results suggest that the CsA concentrations administered in our experimental protocol were able to induce immunosuppression in rats without causing nephro and hepatotoxicity.
    Keywords blood serum ; cyclosporine ; therapeutics ; interleukin-2 ; corn oil ; creatinine ; interleukin-1alpha ; histopathology ; interleukin-6 ; biomarkers ; hepatotoxicity ; graft rejection ; patients ; kidneys ; adverse effects ; interferon-gamma ; interleukin-1beta ; liver ; blood chemistry ; rats
    Language English
    Document type Article
    ISSN 0940-2993
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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