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  1. TI=Nephrotic syndrome relapse in a boy with COVID 19
  2. AU="Mazzaocchi, Giuseppina"

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  1. Artikel ; Online: Nephrotic syndrome relapse in a boy with COVID-19.

    Enya, Takuji / Morimoto, Yuichi / Oshima, Rina / Miyazaki, Kohei / Miyazawa, Tomoki / Okada, Mitsuru / Sugimoto, Keisuke

    CEN case reports

    2021  Band 10, Heft 3, Seite(n) 431–434

    Abstract: ... Some infections may induce NS relapse. We describe the clinical course of a child with NS and COVID-19. A 3-year ... management of COVID-19 and NS relapse. As proteinuria worsened, the prednisolone dose was increased to 2 mg ... Clinical data on coronavirus disease-19 (COVID-19) in children during the management ...

    Abstract Clinical data on coronavirus disease-19 (COVID-19) in children during the management of nephrotic syndrome (NS) is lacking. Patients on prednisolone are compromised hosts at the risk of severe infections. Some infections may induce NS relapse. We describe the clinical course of a child with NS and COVID-19. A 3-year-old boy was admitted with clinical and laboratory findings indicative of NS. Induction therapy with prednisolone (2 mg/kg/day) induced complete remission. While tapering the dose, he was infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). He developed a high fever and periorbital edema. Urinalysis revealed proteinuria (protein-creatinine ratio: 6.3 g/gCr). He was transferred to our hospital for the concurrent management of COVID-19 and NS relapse. As proteinuria worsened, the prednisolone dose was increased to 2 mg/kg/day. Proteinuria gradually improved, and remission was noted a week after initiating full-dose steroid treatment. The fever subsided after 2 days without treatment for COVID-19. Anti-SARS-CoV-2 antibody including IgG levels decreased in the early convalescent phase. To the best of our knowledge, this is the first reported case with the recurrence of NS triggered by the SARS-CoV-2 infection in Asia. SARS-CoV-2 infection may induce NS relapse. Daily administration of full-dose of prednisolone may be effective for managing the recurrence of NS associated with SARS-CoV-2 infection.
    Mesh-Begriff(e) COVID-19/complications ; Child, Preschool ; Humans ; Male ; Nephrotic Syndrome/complications ; Recurrence
    Sprache Englisch
    Erscheinungsdatum 2021-02-22
    Erscheinungsland Japan
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2660492-9
    ISSN 2192-4449 ; 2192-4449
    ISSN (online) 2192-4449
    ISSN 2192-4449
    DOI 10.1007/s13730-021-00587-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Case of recurrent refractory nephrotic syndrome in a Japanese boy with COVID-19.

    Watanabe, Yoshitaka / Watanabe, Tsuneki / Ikeda, Hirokazu

    Pediatrics international : official journal of the Japan Pediatric Society

    2021  Band 64, Heft 1, Seite(n) e14862

    Mesh-Begriff(e) COVID-19 ; Humans ; Japan ; Male ; Mycophenolic Acid ; Nephrotic Syndrome/diagnosis ; Recurrence ; SARS-CoV-2
    Chemische Substanzen Mycophenolic Acid (HU9DX48N0T)
    Sprache Englisch
    Erscheinungsdatum 2021-12-02
    Erscheinungsland Australia
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.14862
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Late Onset of ANCA Vasculitis as a Side Effect of Levamisole Treatment in Nephrotic Syndrome.

    Bernardi, Silvia / Innocenti, Samantha / Charbit, Marina / Boyer, Olivia

    Medicina (Kaunas, Lithuania)

    2022  Band 58, Heft 5

    Abstract: ... of the second dose of the COVID-19 vaccine, it was initially concluded that these manifestations were rare ... Levamisole is effectively used in steroid-dependent nephrotic syndrome and the more frequent ... affected with steroid-dependent nephrotic syndrome was treated with Levamisole as a steroid-sparing agent ...

    Abstract Levamisole is effectively used in steroid-dependent nephrotic syndrome and the more frequent side effects reported are cytopenia and liver enzymes alterations. Several studies have demonstrated that this drug can induce high titers of circulating perinuclear antineutrophil cytoplasmic autoantibodies (ANCA) and vasculitis, most of them occurring in the case of prolonged use. A four-year-old boy that was affected with steroid-dependent nephrotic syndrome was treated with Levamisole as a steroid-sparing agent at a dose of 2 mg/kg/48 h. After initiation of the treatment, the number of relapses drastically decreased, enabling a significant reduction in the cumulative steroid dose. Levamisole was well tolerated, and was therefore administered for several years. At the age of 15, he was also diagnosed with celiac disease. After nine years of continuous Levamisole treatment, he presented with a high fever, hand and foot joint arthritis, and increased levels of total and direct bilirubin. Since the symptoms started two days after the injection of the second dose of the COVID-19 vaccine, it was initially concluded that these manifestations were rare vaccination side effects. Therefore, he did not receive any specific treatments, and Levamisole was continued at the same dose. After an initial improvement, two months later, the patient presented with the same symptoms. Suspecting Levamisole-induced vasculitis, an ANCA titer was measured and this returned positive. Clinical manifestations and double positivity for both myeloperoxidase (MPO) and anti-proteinase 3 (PR3) antibodies argued against the fact that that these findings were secondary to vaccination, cocaine abuse, or celiac disease. Assuming that we were facing a rare drug reaction, Levamisole was promptly interrupted. This resulted in a rapid remission of fever and arthritis improvement, and a decrease in ANCA titers. By reporting this case, we want to raise awareness among clinicians regarding a rare complication of treatment with Levamisole that is often misdiagnosed due to the fact that the current literature lacks univocal guidelines regarding the precise timing of ANCA titrations and the duration of the treatment.
    Mesh-Begriff(e) Antibodies, Antineutrophil Cytoplasmic ; Arthritis ; COVID-19 ; COVID-19 Vaccines ; Celiac Disease ; Child, Preschool ; Humans ; Levamisole/adverse effects ; Male ; Neoplasm Recurrence, Local ; Nephrotic Syndrome ; Vasculitis/chemically induced
    Chemische Substanzen Antibodies, Antineutrophil Cytoplasmic ; COVID-19 Vaccines ; Levamisole (2880D3468G)
    Sprache Englisch
    Erscheinungsdatum 2022-05-11
    Erscheinungsland Switzerland
    Dokumenttyp Case Reports
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58050650
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6270: Hefte anzeigen Standort:
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  4. Artikel ; Online: Late Onset of ANCA Vasculitis as a Side Effect of Levamisole Treatment in Nephrotic Syndrome

    Silvia Bernardi / Samantha Innocenti / Marina Charbit / Olivia Boyer

    Medicina, Vol 58, Iss 650, p

    2022  Band 650

    Abstract: ... of the second dose of the COVID-19 vaccine, it was initially concluded that these manifestations were rare ... Levamisole is effectively used in steroid-dependent nephrotic syndrome and the more frequent ... affected with steroid-dependent nephrotic syndrome was treated with Levamisole as a steroid-sparing agent ...

    Abstract Levamisole is effectively used in steroid-dependent nephrotic syndrome and the more frequent side effects reported are cytopenia and liver enzymes alterations. Several studies have demonstrated that this drug can induce high titers of circulating perinuclear antineutrophil cytoplasmic autoantibodies (ANCA) and vasculitis, most of them occurring in the case of prolonged use. A four-year-old boy that was affected with steroid-dependent nephrotic syndrome was treated with Levamisole as a steroid-sparing agent at a dose of 2 mg/kg/48 h. After initiation of the treatment, the number of relapses drastically decreased, enabling a significant reduction in the cumulative steroid dose. Levamisole was well tolerated, and was therefore administered for several years. At the age of 15, he was also diagnosed with celiac disease. After nine years of continuous Levamisole treatment, he presented with a high fever, hand and foot joint arthritis, and increased levels of total and direct bilirubin. Since the symptoms started two days after the injection of the second dose of the COVID-19 vaccine, it was initially concluded that these manifestations were rare vaccination side effects. Therefore, he did not receive any specific treatments, and Levamisole was continued at the same dose. After an initial improvement, two months later, the patient presented with the same symptoms. Suspecting Levamisole-induced vasculitis, an ANCA titer was measured and this returned positive. Clinical manifestations and double positivity for both myeloperoxidase (MPO) and anti-proteinase 3 (PR3) antibodies argued against the fact that that these findings were secondary to vaccination, cocaine abuse, or celiac disease. Assuming that we were facing a rare drug reaction, Levamisole was promptly interrupted. This resulted in a rapid remission of fever and arthritis improvement, and a decrease in ANCA titers. By reporting this case, we want to raise awareness among clinicians regarding a rare complication of treatment with Levamisole that is often ...
    Schlagwörter ANCA-vasculitis ; nephrotic syndrome ; Levamisole ; children ; case report ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: SARS-CoV-2 infection associated with the recurrence of nephrotic syndrome in a Japanese boy.

    Enya, Takuji / Sugimoto, Keisuke

    Pediatric nephrology (Berlin, Germany)

    2020  Band 36, Heft 1, Seite(n) 209

    Mesh-Begriff(e) COVID-19 ; Child ; Humans ; Japan ; Kidney ; Male ; Nephrotic Syndrome ; Pandemics ; SARS-CoV-2
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-09-29
    Erscheinungsland Germany
    Dokumenttyp Letter ; Comment
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-020-04782-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2196: Hefte anzeigen Standort:
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  6. Artikel ; Online: New-onset pediatric nephrotic syndrome following Pfizer-BioNTech SARS-CoV-2 vaccination: a case report and literature review.

    Nakazawa, Eriko / Uchimura, Toru / Hirai, Yuji / Togashi, Hayato / Oyama, Yoshitaka / Inaba, Aya / Shiga, Kentaro / Ito, Shuichi

    CEN case reports

    2021  Band 11, Heft 2, Seite(n) 242–246

    Abstract: ... rapidly developed. The new onset and recurrence of nephrotic syndrome triggered by some vaccines have been ... documented and several adult cases of minimal change nephrotic syndrome newly developing after SARS-CoV-2 ... developed nephrotic syndrome after SARS-CoV-2 vaccination with BNT162b2 (Pfizer-BioNTech). He developed ...

    Abstract Various new vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been rapidly developed. The new onset and recurrence of nephrotic syndrome triggered by some vaccines have been documented and several adult cases of minimal change nephrotic syndrome newly developing after SARS-CoV-2 vaccination have been reported. However, no reports of pediatric cases have been published. Indications for SARS-CoV-2 vaccines have been expanded to those as young as 12 years old and vaccination of children has just started in Japan. We encountered a 15-year-old boy without underlying disease who newly developed nephrotic syndrome after SARS-CoV-2 vaccination with BNT162b2 (Pfizer-BioNTech). He developed eyelid edema 4 days after vaccination and peripheral edema of the lower extremities a further 4 days later. Twenty-one days after vaccination, 60 mg of oral daily prednisolone was started. He achieved complete remission in 12 days without complications such as hypertension or acute kidney injury. We clinicians should be aware of the possibility of nephrotic syndrome developing after SARS-CoV-2 vaccination, not only in adults, but also in children.
    Mesh-Begriff(e) Adolescent ; Adult ; BNT162 Vaccine ; COVID-19 ; COVID-19 Vaccines/adverse effects ; Child ; Edema ; Female ; Humans ; Male ; Nephrotic Syndrome/drug therapy ; Nephrotic Syndrome/etiology ; SARS-CoV-2 ; Vaccination/adverse effects
    Chemische Substanzen COVID-19 Vaccines ; BNT162 Vaccine (N38TVC63NU)
    Sprache Englisch
    Erscheinungsdatum 2021-11-15
    Erscheinungsland Japan
    Dokumenttyp Case Reports ; Journal Article ; Review
    ZDB-ID 2660492-9
    ISSN 2192-4449 ; 2192-4449
    ISSN (online) 2192-4449
    ISSN 2192-4449
    DOI 10.1007/s13730-021-00656-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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