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Article: Time to SARS-CoV-2 PCR Clearance in Immunocompromising Conditions: Is Test-Based Removal From Isolation Necessary in Severely Immunocompromised Individuals?

Epstein, Rachel L / Sperring, Heather / Hofman, Melissa / Lodi, Sara / White, Laura F / Barocas, Joshua A / Bouton, Tara C / Xiao, Yian / Hsu, Heather E / Miller, Nancy S / Linas, Benjamin P / Marathe, Jai G

Open forum infectious diseases

2021  Volume 8, Issue 6, Page(s) ofab164

Abstract: ... to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) clearance, we studied 3758 adults ... retested following initial SARS-CoV-2 infection. Cox proportional hazards models demonstrated delayed PCR ... To determine the association between immunosuppression and time ...

Abstract To determine the association between immunosuppression and time to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) clearance, we studied 3758 adults retested following initial SARS-CoV-2 infection. Cox proportional hazards models demonstrated delayed PCR clearance with older age, multiple comorbidities, and solid organ transplant but not by degree of immunocompromise. These findings challenge current retesting practices.
Language English
Publishing date 2021-05-20
Publishing country United States
Document type Journal Article
ZDB-ID 2757767-3
ISSN 2328-8957
ISSN 2328-8957
DOI 10.1093/ofid/ofab164
Database MEDical Literature Analysis and Retrieval System OnLINE

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