LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. TI=Effect of Mutant p53 Proteins on Glycolysis and Mitochondrial Metabolism
  2. AU="Plesia, Maria"

Suchergebnis

Treffer 1 - 4 von insgesamt 4

Suchoptionen

  1. Artikel ; Online: Effect of Mutant p53 Proteins on Glycolysis and Mitochondrial Metabolism

    Eriksson, Matilda / Ambroise, Gorbatchev / Ouchida, Amanda Tomie / Lima Queiroz, Andre / Smith, Dominique / Gimenez-Cassina, Alfredo / Iwanicki, Marcin P. / Muller, Patricia A. / Norberg, Erik / Vakifahmetoglu-Norberg, Helin

    Molecular and Cellular Biology. 2017 Dec. 1, v. 37, no. 24 p.e00328-17-

    2017  

    Abstract: ... mutant p53 proteins on cancer cell metabolism is largely unknown. In this study, we have ... events. Recently, mutant p53 proteins have been shown to mediate metabolic changes as a novel GOF ... in cellular metabolism, might vary between the different p53 mutants. Accordingly, the effect of different ...

    Abstract TP53 is one of the most commonly mutated genes in human cancers. Unlike other tumor suppressors that are frequently deleted or acquire loss-of-function mutations, the majority of TP53 mutations in tumors are missense substitutions, which lead to the expression of full-length mutant proteins that accumulate in cancer cells and may confer unique gain-of-function (GOF) activities to promote tumorigenic events. Recently, mutant p53 proteins have been shown to mediate metabolic changes as a novel GOF to promote tumor development. There is a strong rationale that the GOF activities, including alterations in cellular metabolism, might vary between the different p53 mutants. Accordingly, the effect of different mutant p53 proteins on cancer cell metabolism is largely unknown. In this study, we have metabolically profiled several individual frequently occurring p53 mutants in cancers, focusing on glycolytic and mitochondrial oxidative phosphorylation pathways. Our investigation highlights the diversity of different p53 mutants in terms of their effect on metabolism, which might provide a foundation for the development of more effective targeted pharmacological approaches toward variants of mutant p53.
    Schlagwörter gain-of-function mutation ; glycolysis ; humans ; loss-of-function mutation ; mitochondria ; mutants ; neoplasm cells ; neoplasms ; oxidative phosphorylation ; cancer ; EMT ; OxPhos ; metabolism ; mutant p53
    Sprache Englisch
    Erscheinungsverlauf 2017-1201
    Erscheinungsort Taylor & Francis
    Dokumenttyp Artikel ; Online
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1128/MCB.00328-17
    Datenquelle NAL Katalog (AGRICOLA)

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1666: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel ; Online: The Warburg effect is genetically determined in inherited pheochromocytomas.

    Favier, Judith / Brière, Jean-Jacques / Burnichon, Nelly / Rivière, Julie / Vescovo, Laure / Benit, Paule / Giscos-Douriez, Isabelle / De Reyniès, Aurélien / Bertherat, Jérôme / Badoual, Cécile / Tissier, Frédérique / Amar, Laurence / Libé, Rosella / Plouin, Pierre-François / Jeunemaitre, Xavier / Rustin, Pierre / Gimenez-Roqueplo, Anne-Paule

    PloS one

    2009  Band 4, Heft 9, Seite(n) e7094

    Abstract: ... we studied mitochondrial electron transport, angiogenesis and glycolysis in pheochromocytomas induced ... gene mutated. Our data suggest an unexpected association between pseudohypoxia and loss of p53, which leads ... preferentially use glycolysis to generate energy. To evaluate the link between hypoxia and Warburg effect ...

    Abstract The Warburg effect describes how cancer cells down-regulate their aerobic respiration and preferentially use glycolysis to generate energy. To evaluate the link between hypoxia and Warburg effect, we studied mitochondrial electron transport, angiogenesis and glycolysis in pheochromocytomas induced by germ-line mutations in VHL, RET, NF1 and SDH genes. SDH and VHL gene mutations have been shown to lead to the activation of hypoxic response, even in normoxic conditions, a process now referred to as pseudohypoxia. We observed a decrease in electron transport protein expression and activity, associated with increased angiogenesis in SDH- and VHL-related, pseudohypoxic tumors, while stimulation of glycolysis was solely observed in VHL tumors. Moreover, microarray analyses revealed that expression of genes involved in these metabolic pathways is an efficient tool for classification of pheochromocytomas in accordance with the predisposition gene mutated. Our data suggest an unexpected association between pseudohypoxia and loss of p53, which leads to a distinct Warburg effect in VHL-related pheochromocytomas.
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Child ; Electron Transport ; Female ; Genes, p53/genetics ; Germ-Line Mutation ; Glycolysis ; Humans ; Hypoxia ; Male ; Middle Aged ; Mitochondria/metabolism ; Neovascularization, Pathologic ; Oligonucleotide Array Sequence Analysis ; Oxidative Phosphorylation ; Pheochromocytoma/genetics ; Pheochromocytoma/physiopathology
    Sprache Englisch
    Erscheinungsdatum 2009-09-18
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0007094
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel ; Online: The Warburg effect is genetically determined in inherited pheochromocytomas.

    Judith Favier / Jean-Jacques Brière / Nelly Burnichon / Julie Rivière / Laure Vescovo / Paule Benit / Isabelle Giscos-Douriez / Aurélien De Reyniès / Jérôme Bertherat / Cécile Badoual / Frédérique Tissier / Laurence Amar / Rosella Libé / Pierre-François Plouin / Xavier Jeunemaitre / Pierre Rustin / Anne-Paule Gimenez-Roqueplo

    PLoS ONE, Vol 4, Iss 9, p e

    2009  Band 7094

    Abstract: ... we studied mitochondrial electron transport, angiogenesis and glycolysis in pheochromocytomas induced ... gene mutated. Our data suggest an unexpected association between pseudohypoxia and loss of p53, which leads ... preferentially use glycolysis to generate energy. To evaluate the link between hypoxia and Warburg effect ...

    Abstract The Warburg effect describes how cancer cells down-regulate their aerobic respiration and preferentially use glycolysis to generate energy. To evaluate the link between hypoxia and Warburg effect, we studied mitochondrial electron transport, angiogenesis and glycolysis in pheochromocytomas induced by germ-line mutations in VHL, RET, NF1 and SDH genes. SDH and VHL gene mutations have been shown to lead to the activation of hypoxic response, even in normoxic conditions, a process now referred to as pseudohypoxia. We observed a decrease in electron transport protein expression and activity, associated with increased angiogenesis in SDH- and VHL-related, pseudohypoxic tumors, while stimulation of glycolysis was solely observed in VHL tumors. Moreover, microarray analyses revealed that expression of genes involved in these metabolic pathways is an efficient tool for classification of pheochromocytomas in accordance with the predisposition gene mutated. Our data suggest an unexpected association between pseudohypoxia and loss of p53, which leads to a distinct Warburg effect in VHL-related pheochromocytomas.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2009-09-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  4. Artikel ; Online: Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer.

    Tang, Meng / Xu, Hui / Huang, Hongyan / Kuang, Hao / Wang, Chenxi / Li, Qinqin / Zhang, Xin / Ge, Yizhong / Song, Mengmeng / Zhang, Xi / Wang, Ziwen / Ma, Chaobing / Kang, Jinlin / Zhang, Wanfang / Wang, You / Zhang, Bo / Zhang, Xiaowei / Chen, Yongbing / Cong, Minghua /
    Melino, Gerry / Wang, Xiaobin / Zhou, Fuxiang / Sun, Qiang / Shi, Hanping

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2022  Band 9, Heft 29, Seite(n) e2201992

    Abstract: ... of mutant p53 effectively blocks the rewired molecular expression and the reprogrammed metabolism, leading ... therapy in colon cancer and identify mutant p53 as a synthetic lethality target for ketogenic treatment. ... on accurate molecular and metabolic subtyping. Here, this study reports two metabolism-based molecular ...

    Abstract Although targeting cancer metabolism is a promising therapeutic strategy, clinical success depends on accurate molecular and metabolic subtyping. Here, this study reports two metabolism-based molecular subtypes associated with the ketogenic treatment of colon cancer: glycolytic (glycolysis<sup>+</sup> /ketolysis<sup>-</sup> ) and ketolytic (glycolysis<sup>+</sup> /ketolysis<sup>+</sup> ), which are manifested by distinct profiles of metabolic enzymes and mitochondrial dysfunction, and by different responses to ketone-containing interventions in vitro and in vivo. Notably, the glycolytic subtype is able to be transformed into the ketolytic subtype in p53-mutated tumors upon glucose limitation, rendering resistance to ketogenic therapy associated with upregulation of ketolytic enzymes, such as OXCT1 by mutant p53. The allosteric activator of mutant p53 effectively blocks the rewired molecular expression and the reprogrammed metabolism, leading to the suppression of tumor growth. The findings highlight the utility of metabolic subtyping to guide ketogenic therapy in colon cancer and identify mutant p53 as a synthetic lethality target for ketogenic treatment.
    Mesh-Begriff(e) Colonic Neoplasms/genetics ; Colonic Neoplasms/therapy ; Glucose/metabolism ; Humans ; Ketone Bodies ; Ketones ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
    Chemische Substanzen Ketone Bodies ; Ketones ; Tumor Suppressor Protein p53 ; Glucose (IY9XDZ35W2)
    Sprache Englisch
    Erscheinungsdatum 2022-08-28
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202201992
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang