Article ; Online: Role of oxidized LDL-induced "trained macrophages" in the pathogenesis of COVID-19 and benefits of pioglitazone: A hypothesis.
2020 Volume 14, Issue 4, Page(s) 713–714
Abstract: ... on the trained immunity and cytokine storm of COVID-19.: Results and conclusions: When oxLDL-trained ... oxidized LDL) plays major role. Receptor-mediated uptake of oxLDL by the monocyte-derived macrophages ... the activities of these specific macrophages.: Methods: Search in Medline and PubMed relevant articles ...
| Abstract | Background and aims: Older adults and people who have cardiovascular disorders (their common pathogenetic mechanism is progressive atherosclerosis) are at higher risk for severe illness from COVID-19 (coronavirus disease 2019). Their common pathogenetic mechanism is progressive atherosclerosis in which oxLDL (oxidized LDL) plays major role. Receptor-mediated uptake of oxLDL by the monocyte-derived macrophages activates the long-term epigenetic reprogramming of innate immunity, which is termed "trained immunity." The aim of this work is to investigate the mechanisms and treatment possibilities that can control the activities of these specific macrophages. Methods: Search in Medline and PubMed relevant articles on the trained immunity and cytokine storm of COVID-19. Results and conclusions: When oxLDL-trained macrophages encounter SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) in the lung, it causes unregulated cytokine secretion, leading to the alveolar damage. Therefore, blocking macrophage training by pioglitazone, a thiazolidinedione, could control the hyperactivation that the virus would trigger. |
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| MeSH term(s) | Atherosclerosis/drug therapy ; Atherosclerosis/immunology ; Atherosclerosis/physiopathology ; Betacoronavirus/drug effects ; Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/immunology ; Coronavirus Infections/physiopathology ; Humans ; Immunity, Innate ; Inflammation Mediators ; Lipoproteins, LDL/therapeutic use ; Macrophages/drug effects ; Macrophages/immunology ; Pandemics ; Pioglitazone/pharmacology ; Pioglitazone/therapeutic use ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/immunology ; Pneumonia, Viral/physiopathology ; SARS-CoV-2 ; Signal Transduction |
| Chemical Substances | Inflammation Mediators ; Lipoproteins, LDL ; oxidized low density lipoprotein ; Pioglitazone (X4OV71U42S) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-05-12 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Review |
| ZDB-ID | 2273766-2 |
| ISSN | 1878-0334 ; 1871-4021 |
| ISSN (online) | 1878-0334 |
| ISSN | 1871-4021 |
| DOI | 10.1016/j.dsx.2020.05.007 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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