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  1. Article: Regulating the regulators: Aurora A activation and mitosis.

    Eyers, Patrick A / Maller, James L

    Cell cycle (Georgetown, Tex.)

    2003  Volume 2, Issue 4, Page(s) 287–289

    MeSH term(s) Animals ; Aurora Kinases ; Cell Cycle Proteins/metabolism ; Cell Division/physiology ; Enzyme Activation/physiology ; Histones/metabolism ; Humans ; Microtubule-Associated Proteins/metabolism ; Mitosis/physiology ; Neoplasm Proteins/metabolism ; Nuclear Proteins/metabolism ; Phosphoprotein Phosphatases/metabolism ; Phosphoproteins/metabolism ; Phosphorylation ; Protein Kinases/metabolism ; Protein-Serine-Threonine Kinases ; Saccharomyces cerevisiae/metabolism ; Spindle Apparatus/metabolism ; Tubulin/metabolism ; Tyrosine/metabolism ; Xenopus/metabolism ; Xenopus Proteins
    Chemical Substances Cell Cycle Proteins ; Histones ; Microtubule-Associated Proteins ; Neoplasm Proteins ; Nuclear Proteins ; Phosphoproteins ; TPX2 protein, Xenopus ; TPX2 protein, human ; Tubulin ; Xenopus Proteins ; Tyrosine (42HK56048U) ; Protein Kinases (EC 2.7.-) ; AURKA protein, Xenopus (EC 2.7.11.1) ; Aurora Kinases (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; Phosphoprotein Phosphatases (EC 3.1.3.16)
    Language English
    Publishing date 2003-06-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5881: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: RACK1 affects the progress of G2/M by regulating Aurora-A.

    Shen, Suqin / Feng, Huan / Le, Yichen / Ni, Jun / Yu, Long / Wu, Jiaxue / Bai, Meirong

    Cell cycle (Georgetown, Tex.)

    2019  Volume 18, Issue 18, Page(s) 2228–2238

    Abstract: ... A in vitro and in vivo. Depletion of RACK1 impaired the activation of Aurora-A in late G2 phase ... of activated C-kinase1 (RACK1), an important regulator of biological functions, interacted with Aurora-A and co ... Aurora-A is a serine/threonine kinase, which is overexpressed in multiple human cancers and plays ...

    Abstract Aurora-A is a serine/threonine kinase, which is overexpressed in multiple human cancers and plays a key role in tumorigenesis and tumor development. In this study, we found that the receptor of activated C-kinase1 (RACK1), an important regulator of biological functions, interacted with Aurora-A and co-localized with Aurora-A at centrosomes. Moreover, RACK1 induces the auto-phosphorylation of Aurora-A in vitro and in vivo. Depletion of RACK1 impaired the activation of Aurora-A in late G2 phase, then inhibited the mitotic entry and leaded to multi-polarity, severe chromosome alignment defects, or centrosome amplification. Taken together, these results suggest that RACK1 is a new partner of Aurora-A and play a critical role in the regulation of the Aurora-A activity during mitosis, which may provide a basis for future anticancer studies targeting Aurora-A.
    MeSH term(s) Aurora Kinase A/chemistry ; Aurora Kinase A/genetics ; Aurora Kinase A/metabolism ; Catalytic Domain ; Centrosome/metabolism ; G2 Phase Cell Cycle Checkpoints/genetics ; HeLa Cells ; Humans ; M Phase Cell Cycle Checkpoints/genetics ; Neoplasm Proteins/chemistry ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Phosphorylation/genetics ; Protein Binding ; Protein Stability ; Receptors for Activated C Kinase/chemistry ; Receptors for Activated C Kinase/genetics ; Receptors for Activated C Kinase/metabolism ; Signal Transduction/genetics ; Spindle Apparatus/metabolism ; Transfection
    Chemical Substances Neoplasm Proteins ; RACK1 protein, human ; Receptors for Activated C Kinase ; AURKA protein, human (EC 2.7.11.1) ; Aurora Kinase A (EC 2.7.11.1)
    Language English
    Publishing date 2019-07-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.1080/15384101.2019.1642065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5881: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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