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  1. Article ; Online: Research progress on repositioning drugs and specific therapeutic drugs for SARS-CoV-2.

    Fan, Shiyong / Xiao, Dian / Wang, Yanming / Liu, Lianqi / Zhou, Xinbo / Zhong, Wu

    Future medicinal chemistry

    2020  Volume 12, Issue 17, Page(s) 1565–1578

    Abstract: ... in the development of anti-SARS-CoV-2 drugs, and proposes novel short-term and long-term drug research strategies. ... has become an urgent work worldwide. At present, potential therapeutic targets and drugs for SARS-CoV ... 2 are continuously reported, and many repositioning drugs are undergoing extensive clinical research ...

    Abstract SARS-CoV-2 has been widely spread around the world and COVID-19 was declared a global pandemic by the WHO. Limited clinically effective antiviral drugs are available now. The development of anti-SARS-CoV-2 drugs has become an urgent work worldwide. At present, potential therapeutic targets and drugs for SARS-CoV-2 are continuously reported, and many repositioning drugs are undergoing extensive clinical research, including remdesivir and chloroquine. On the other hand, structures of many important viral target proteins and host target proteins, including that of RdRp and Mpro were constantly reported, which greatly promoted structure-based drug design. This paper summarizes the current research progress and challenges in the development of anti-SARS-CoV-2 drugs, and proposes novel short-term and long-term drug research strategies.
    MeSH term(s) Antiviral Agents/therapeutic use ; Betacoronavirus/chemistry ; Betacoronavirus/drug effects ; COVID-19 ; Clinical Trials as Topic ; Coronavirus Infections/drug therapy ; Drug Repositioning ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; SARS-CoV-2 ; Viral Proteins/chemistry ; Viral Proteins/drug effects
    Chemical Substances Antiviral Agents ; Viral Proteins
    Keywords covid19
    Language English
    Publishing date 2020-07-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1756-8927
    ISSN (online) 1756-8927
    DOI 10.4155/fmc-2020-0158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Research progress on repositioning drugs and specific therapeutic drugs for SARS-CoV-2

    Fan, Shiyong / Xiao, Dian / Wang, Yanming / Liu, Lianqi / Zhou, Xinbo / Zhong, Wu

    Future Med Chem

    Abstract: ... in the development of anti-SARS-CoV-2 drugs, and proposes novel short-term and long-term drug research strategies. ... has become an urgent work worldwide. At present, potential therapeutic targets and drugs for SARS-CoV ... 2 are continuously reported, and many repositioning drugs are undergoing extensive clinical research ...

    Abstract SARS-CoV-2 has been widely spread around the world and COVID-19 was declared a global pandemic by the WHO. Limited clinically effective antiviral drugs are available now. The development of anti-SARS-CoV-2 drugs has become an urgent work worldwide. At present, potential therapeutic targets and drugs for SARS-CoV-2 are continuously reported, and many repositioning drugs are undergoing extensive clinical research, including remdesivir and chloroquine. On the other hand, structures of many important viral target proteins and host target proteins, including that of RdRp and Mpro were constantly reported, which greatly promoted structure-based drug design. This paper summarizes the current research progress and challenges in the development of anti-SARS-CoV-2 drugs, and proposes novel short-term and long-term drug research strategies.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #637735
    Database COVID19

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  3. Article ; Online: Virus-CKB: an integrated bioinformatics platform and analysis resource for COVID-19 research.

    Feng, Zhiwei / Chen, Maozi / Liang, Tianjian / Shen, Mingzhe / Chen, Hui / Xie, Xiang-Qun

    Briefings in bioinformatics

    2020  Volume 22, Issue 2, Page(s) 882–895

    Abstract: ... by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is an urgent need for medicines that can help before vaccines ... the FDA-approved drugs which can quickly progress into clinical trials to meet the urgent demand ... Given the scale and rapid spread of the coronavirus disease 2019 (COVID-19) caused ...

    Abstract Given the scale and rapid spread of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is an urgent need for medicines that can help before vaccines are available. In this study, we present a viral-associated disease-specific chemogenomics knowledgebase (Virus-CKB) and apply our computational systems pharmacology-target mapping to rapidly predict the FDA-approved drugs which can quickly progress into clinical trials to meet the urgent demand of the COVID-19 outbreak. Virus-CKB reuses the underlying platform of our DAKB-GPCRs but adds new features like multiple-compound support, multi-cavity protein support and customizable symbol display. Our one-stop computing platform describes the chemical molecules, genes and proteins involved in viral-associated diseases regulation. To date, Virus-CKB archived 65 antiviral drugs in the market, 107 viral-related targets with 189 available 3D crystal or cryo-EM structures and 2698 chemical agents reported for these target proteins. Moreover, Virus-CKB is implemented with web applications for the prediction of the relevant protein targets and analysis and visualization of the outputs, including HTDocking, TargetHunter, BBB predictor, NGL Viewer, Spider Plot, etc. The Virus-CKB server is accessible at https://www.cbligand.org/g/virus-ckb.
    MeSH term(s) Antiviral Agents/pharmacology ; COVID-19/pathology ; COVID-19/virology ; Computational Biology ; Drug Repositioning ; Humans ; Molecular Docking Simulation ; SARS-CoV-2/drug effects ; SARS-CoV-2/isolation & purification
    Chemical Substances Antiviral Agents
    Keywords covid19
    Language English
    Publishing date 2020-07-20
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2068142-2
    ISSN 1477-4054 ; 1467-5463
    ISSN (online) 1477-4054
    ISSN 1467-5463
    DOI 10.1093/bib/bbaa155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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