Article ; Online: Transient plasma cell dyscrasia in COVID-19 patients linked to IL-6 triggering.
2021 Volume 23, Issue 4-5, Page(s) 104808
Abstract: ... We can conclude that elevated levels of IL-6 triggers humoral response inducing a transient plasma cell dyscrasia ... in severe COVID-19 patients. ... patients swab positive and investigated serological levels of IL-6, immune response to major viral antigens ...
| Abstract | An unusual clonal gammopathy was reported in COVID-19 patient but whether this anomaly is related or not to the disease has not yet been clarified. To this aim, we selected a cohort of 35 COVID-19 patients swab positive and investigated serological levels of IL-6, immune response to major viral antigens and electrophoretic profile. Elevated levels of IL-6 were accompanied by a significative humoral response to viral Spike protein, revealing an altered electrophoretic profile in the gamma region. We can conclude that elevated levels of IL-6 triggers humoral response inducing a transient plasma cell dyscrasia in severe COVID-19 patients. |
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| MeSH term(s) | Aged ; Antibodies, Viral/blood ; COVID-19/complications ; COVID-19/immunology ; Coronavirus Nucleocapsid Proteins/immunology ; Female ; Humans ; Interleukin-6/immunology ; Italy ; Male ; Paraproteinemias/immunology ; Paraproteinemias/virology ; Phosphoproteins/immunology ; Spike Glycoprotein, Coronavirus/immunology | |||||
| Chemical Substances | Antibodies, Viral ; Coronavirus Nucleocapsid Proteins ; IL6 protein, human ; Interleukin-6 ; Phosphoproteins ; Spike Glycoprotein, Coronavirus ; nucleocapsid phosphoprotein, SARS-CoV-2 ; spike protein, SARS-CoV-2 | |||||
| Language | English | |||||
| Publishing date | 2021-03-20 | |||||
| Publishing country | France | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1465093-9 | |||||
| ISSN | 1769-714X ; 1286-4579 | |||||
| ISSN (online) | 1769-714X | |||||
| ISSN | 1286-4579 | |||||
| DOI | 10.1016/j.micinf.2021.104808 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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