Article ; Online: T cell-mediated response to SARS-CoV-2 in liver transplant recipients with prior COVID-19.
2021 Volume 21, Issue 8, Page(s) 2785–2794
Abstract: ... cell-mediated immunity (SARS-CoV-2-CMI) after liver transplantation (LT) remains unknown. We included 31 LT recipients ... time from diagnosis. Post-transplant SARS-CoV-2-CMI was detected by ICS in 90.3% (28/31) of recipients ... assay after a median of 103 days from COVID-19 diagnosis. Serum SARS-CoV-2 IgG antibodies were measured ...
| Abstract | Whether immunosuppression impairs severe acute respiratory syndrome coronavirus 2-specific T cell-mediated immunity (SARS-CoV-2-CMI) after liver transplantation (LT) remains unknown. We included 31 LT recipients in whom SARS-CoV-2-CMI was assessed by intracellular cytokine staining (ICS) and interferon (IFN)-γ FluoroSpot assay after a median of 103 days from COVID-19 diagnosis. Serum SARS-CoV-2 IgG antibodies were measured by ELISA. A control group of nontransplant immunocompetent patients were matched (1:1 ratio) by age and time from diagnosis. Post-transplant SARS-CoV-2-CMI was detected by ICS in 90.3% (28/31) of recipients, with higher proportions for IFN-γ-producing CD4 |
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| MeSH term(s) | Antibodies, Viral ; COVID-19 ; COVID-19 Testing ; Humans ; Liver Transplantation/adverse effects ; SARS-CoV-2 ; T-Lymphocytes ; Transplant Recipients | |||||
| Chemical Substances | Antibodies, Viral | |||||
| Language | English | |||||
| Publishing date | 2021-06-25 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 2060594-8 | |||||
| ISSN | 1600-6143 ; 1600-6135 | |||||
| ISSN (online) | 1600-6143 | |||||
| ISSN | 1600-6135 | |||||
| DOI | 10.1111/ajt.16708 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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