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  1. Article ; Online: Correction: Cryopreservation of unrelated donor hematopoietic stem cells: the right answer for transplantations during the COVID-19 pandemic?

    Fernandez-Sojo, Jesus / Azqueta, Carmen / Valdivia, Elena / Martorell, Lluis / Medina-Boronat, Laura / Martínez-Llonch, Nuria / Torrents, Silvia / Codinach, Margarita / Canals, Carme / Elorza, Izaskun / Parody, Rocio / Martino, Rodrigo / Trabazo, Maria / Díaz de Heredia, Cristina / Ferra, Christelle / Valcárcel, David / Linares, Mónica / Ancochea, Águeda / García-Rey, Enric /
    García-Muñoz, Nadia / Medina, Laura / Castillo, Nerea / Carreras, Enric / Villa, Juliana / Querol, Sergio

    Bone marrow transplantation

    2024  

    Language English
    Publishing date 2024-05-28
    Publishing country England
    Document type Published Erratum
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-024-02318-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cryopreservation of unrelated donor hematopoietic stem cells: the right answer for transplantations during the COVID-19 pandemic?

    Fernandez-Sojo, Jesus / Azqueta, Carmen / Valdivia, Elena / Martorell, Lluis / Medina-Boronat, Laura / Martínez-Llonch, Nuria / Torrents, Silvia / Codinach, Margarita / Canals, Carme / Elorza, Izaskun / Parody, Rocio / Martino, Rodrigo / Trabazo, Maria / Díaz de Heredia, Cristina / Ferra, Christelle / Valcárcel, David / Linares, Mónica / Ancochea, Águeda / García-Rey, Enric /
    García-Muñoz, Nadia / Medina, Laura / Castillo, Nerea / Carreras, Enric / Villa, Juliana / Querol, Sergio

    Bone marrow transplantation

    2021  Volume 56, Issue 10, Page(s) 2489–2496

    Abstract: ... hematopoietic stem cell transplantation (HSCT) during COVID-19 pandemic. However, its impact on clinical outcomes and feasibility was not ... stem cells (PBSC) during the COVID-19 pandemic with 32 patients who underwent UD HSCT using fresh PBSC ... differ significantly. During COVID-19 pandemic, six frozen UD donations were not transfused and ...

    Abstract Cryopreservation was recommended to ensure continuity of unrelated donor (UD) hematopoietic stem cell transplantation (HSCT) during COVID-19 pandemic. However, its impact on clinical outcomes and feasibility was not well known. We compared 32 patients who underwent UD HSCT using cryopreserved peripheral blood stem cells (PBSC) during the COVID-19 pandemic with 32 patients who underwent UD HSCT using fresh PBSC in the previous period. Median neutrophil engraftment was 17.5 and 17.0 days with cryopreserved and fresh grafts, respectively. Non-significant delays were found in platelet recovery days (25.5 versus 19.0; P = 0.192) and full donor chimerism days (35.0 and 31.5; P = 0.872) using cryopreserved PBSC. The rate of acute graft-versus-host disease at 100 days was 41% (95% CI [21-55%]) in cryopreserved group versus 31% (95% CI [13-46%]) in fresh group (P = 0.380). One-hundred days progression-relapse free survival and overall survival did not differ significantly. During COVID-19 pandemic, six frozen UD donations were not transfused and logistical and clinical issues regarding cryopreservation procedure, packaging, and transporting appeared. In summary, UD HSCT with cryopreserved PBSC was safe during this challenging time. More efforts are needed to ensure that all frozen grafts are transplanted and cryopreservation requirements are harmonized.
    MeSH term(s) COVID-19 ; Cryopreservation ; Graft vs Host Disease ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells ; Humans ; Pandemics ; SARS-CoV-2 ; Unrelated Donors
    Language English
    Publishing date 2021-06-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-021-01367-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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