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Article ; Online: Headache as an acute and post-COVID-19 symptom in COVID-19 survivors: A meta-analysis of the current literature.

Fernández-de-Las-Peñas, César / Navarro-Santana, Marcos / Gómez-Mayordomo, Víctor / Cuadrado, María L / García-Azorín, David / Arendt-Nielsen, Lars / Plaza-Manzano, Gustavo

European journal of neurology

2021  Volume 28, Issue 11, Page(s) 3820–3825

Abstract: ... survivors. The aim of this pooled analysis was to synthesize the prevalence of post-COVID headache ... patients. Time trend analysis showed a decreased prevalence from the acute symptoms' onset to all post ... Background: Headache is identified as a common post-COVID sequela experienced by COVID-19 ...

Abstract Background: Headache is identified as a common post-COVID sequela experienced by COVID-19 survivors. The aim of this pooled analysis was to synthesize the prevalence of post-COVID headache in hospitalized and non-hospitalized patients recovering from SARS-CoV-2 infection.
Methods: MEDLINE, CINAHL, PubMed, EMBASE, and Web of Science databases, as well as medRxiv and bioRxiv preprint servers, were searched up to 31 May 2021. Studies or preprints providing data on post-COVID headache were included. The methodological quality of the studies was assessed using the Newcastle-Ottawa Scale. Random effects models were used for meta-analytical pooled prevalence of post-COVID headache. Data synthesis was categorized at hospital admission/symptoms' onset, and at 30, 60, 90, and ≥180 days afterwards.
Results: From 9573 studies identified, 28 peer-reviewed studies and 7 preprints were included. The sample was 28,438 COVID-19 survivors (12,307 females; mean age: 46.6, SD: 17.45 years). The methodological quality was high in 45% of the studies. The overall prevalence of post-COVID headache was 47.1% (95% CI 35.8-58.6) at onset or hospital admission, 10.2% (95% CI 5.4-18.5) at 30 days, 16.5% (95% CI 5.6-39.7) at 60 days, 10.6% (95% CI 4.7-22.3) at 90 days, and 8.4% (95% CI 4.6-14.8) at ≥180 days after onset/hospital discharge. Headache as a symptom at the acute phase was more prevalent in non-hospitalized (57.97%) than in hospitalized (31.11%) patients. Time trend analysis showed a decreased prevalence from the acute symptoms' onset to all post-COVID follow-up periods which was maintained afterwards.
Conclusion: This meta-analysis found that the prevalence of post-COVID headache ranged from 8% to 15% during the first 6 months after SARS-CoV-2 infection.
MeSH term(s) Adult ; COVID-19 ; Female ; Headache/epidemiology ; Headache/etiology ; Humans ; Male ; Middle Aged ; Prevalence ; SARS-CoV-2 ; Survivors
Language English
Publishing date 2021-08-08
Publishing country England
Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID 1280785-0
ISSN 1468-1331 ; 1351-5101 ; 1471-0552
ISSN (online) 1468-1331
ISSN 1351-5101 ; 1471-0552
DOI 10.1111/ene.15040
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