Article ; Online: Determinants of COVID-19 Mortality in Patients With Cancer From a Community Oncology Practice in Brazil.
JCO global oncology
2020 Volume 7, Page(s) 46–55
Abstract: ... with cancer and confirmed COVID-19 from Oncoclínicas community oncology practice in Brazil was conducted ... in a noncurative setting (: Conclusion: Mortality after COVID-19 in patients with cancer is influenced ... of mortality in the general population are now clear, but specific data on patients with cancer remain limited ...
| Abstract | Purpose: The COVID-19 pandemic remains a public health emergency of global concern. Determinants of mortality in the general population are now clear, but specific data on patients with cancer remain limited, particularly in Latin America. Materials and methods: A longitudinal multicenter cohort study of patients with cancer and confirmed COVID-19 from Oncoclínicas community oncology practice in Brazil was conducted. The primary end point was all-cause mortality after isolation of the SARS-CoV-2 by Real-Time Polymerase Chain Reaction (RT-PCR) in patients initially diagnosed in an outpatient environment. We performed univariate and multivariable logistic regression analysis and recursive partitioning modeling to define the baseline clinical determinants of death in the overall population. Results: From March 29 to July 4, 2020, 198 patients with COVID-19 were prospectively registered in the database, of which 167 (84%) had solid tumors and 31 (16%) had hematologic malignancies. Most patients were on active systemic therapy or radiotherapy (77%), largely for advanced or metastatic disease (64%). The overall mortality rate was 16.7% (95% CI, 11.9 to 22.7). In univariate models, factors associated with death after COVID-19 diagnosis were age ≥ 60 years, current or former smoking, coexisting comorbidities, respiratory tract cancer, and management in a noncurative setting ( Conclusion: Mortality after COVID-19 in patients with cancer is influenced by prognostic factors that also affect outcomes of the general population. Fragile patients and smokers are entitled to active preventive measures to reduce the risk of SARS-CoV-2 infection and close monitoring in the case of exposure or COVID-19-related symptoms. |
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| MeSH term(s) | Adult ; Aged ; Aged, 80 and over ; Brazil/epidemiology ; COVID-19/diagnosis ; COVID-19/mortality ; COVID-19/virology ; COVID-19 Nucleic Acid Testing/statistics & numerical data ; Cancer Survivors/statistics & numerical data ; Cause of Death ; Databases, Factual/statistics & numerical data ; Female ; Frailty/epidemiology ; Humans ; Longitudinal Studies ; Male ; Medical Oncology/statistics & numerical data ; Middle Aged ; Neoplasms/complications ; Neoplasms/mortality ; Prognosis ; Prospective Studies ; RNA, Viral/isolation & purification ; Risk Assessment/statistics & numerical data ; Risk Factors ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Smoking/epidemiology ; Young Adult |
| Chemical Substances | RNA, Viral |
| Language | English |
| Publishing date | 2020-12-29 |
| Publishing country | United States |
| Document type | Journal Article ; Multicenter Study |
| ISSN | 2687-8941 |
| ISSN (online) | 2687-8941 |
| DOI | 10.1200/GO.20.00444 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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