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  1. Article: Long-Lasting Cognitive Abnormalities after COVID-19.

    Ferrucci, Roberta / Dini, Michelangelo / Groppo, Elisabetta / Rosci, Chiara / Reitano, Maria Rita / Bai, Francesca / Poletti, Barbara / Brugnera, Agostino / Silani, Vincenzo / D'Arminio Monforte, Antonella / Priori, Alberto

    Brain sciences

    2021  Volume 11, Issue 2

    Abstract: Considering the mechanisms capable of causing brain alterations in COVID-19, we aimed to study ... the occurrence of cognitive abnormalities in the months following hospital discharge. We recruited 38 (aged 22-74 ... years; 27 males) patients hospitalized for complications of SARS-CoV-2 infection in nonintensive COVID ...

    Abstract Considering the mechanisms capable of causing brain alterations in COVID-19, we aimed to study the occurrence of cognitive abnormalities in the months following hospital discharge. We recruited 38 (aged 22-74 years; 27 males) patients hospitalized for complications of SARS-CoV-2 infection in nonintensive COVID units. Participants underwent neuropsychological testing about 5 months after hospital discharge. Of all patients, 42.1% had processing speed deficits, while 26.3% showed delayed verbal recall deficits. Twenty-one percent presented with deficits in both processing speed and verbal memory. Bivariate analysis revealed a positive correlation between the lowest arterial oxygen partial pressure (PaO
    Language English
    Publishing date 2021-02-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci11020235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Metabolomic and immune alterations in long COVID patients with chronic fatigue syndrome.

    Saito, Suguru / Shahbaz, Shima / Luo, Xian / Osman, Mohammed / Redmond, Desiree / Cohen Tervaert, Jan Willem / Li, Liang / Elahi, Shokrollah

    Frontiers in immunology

    2024  Volume 15, Page(s) 1341843

    Abstract: ... persistent metabolomic abnormalities 12 months after the acute COVID-19 disease. Of note, such metabolomic ... recovered individuals (R) without LC, acute COVID-19 patients (A), and to SARS-CoV-2 unexposed healthy ... as long COVID (LC), that may last months or years post the onset of acute disease. A portion of LC ...

    Abstract Introduction: A group of SARS-CoV-2 infected individuals present lingering symptoms, defined as long COVID (LC), that may last months or years post the onset of acute disease. A portion of LC patients have symptoms similar to myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), which results in a substantial reduction in their quality of life. A better understanding of the pathophysiology of LC, in particular, ME/CFS is urgently needed.
    Methods: We identified and studied metabolites and soluble biomarkers in plasma from LC individuals mainly exhibiting ME/CFS compared to age-sex-matched recovered individuals (R) without LC, acute COVID-19 patients (A), and to SARS-CoV-2 unexposed healthy individuals (HC).
    Results: Through these analyses, we identified alterations in several metabolomic pathways in LC vs other groups. Plasma metabolomics analysis showed that LC differed from the R and HC groups. Of note, the R group also exhibited a different metabolomic profile than HC. Moreover, we observed a significant elevation in the plasma pro-inflammatory biomarkers (e.g. IL-1α, IL-6, TNF-α, Flt-1, and sCD14) but the reduction in ATP in LC patients. Our results demonstrate that LC patients exhibit persistent metabolomic abnormalities 12 months after the acute COVID-19 disease. Of note, such metabolomic alterations can be observed in the R group 12 months after the acute disease. Hence, the metabolomic recovery period for infected individuals with SARS-CoV-2 might be long-lasting. In particular, we found a significant reduction in sarcosine and serine concentrations in LC patients, which was inversely correlated with depression, anxiety, and cognitive dysfunction scores.
    Conclusion: Our study findings provide a comprehensive metabolomic knowledge base and other soluble biomarkers for a better understanding of the pathophysiology of LC and suggests sarcosine and serine supplementations might have potential therapeutic implications in LC patients. Finally, our study reveals that LC disproportionally affects females more than males, as evidenced by nearly 70% of our LC patients being female.
    MeSH term(s) Male ; Humans ; Female ; Fatigue Syndrome, Chronic ; Post-Acute COVID-19 Syndrome ; Acute Disease ; Quality of Life ; Sarcosine ; SARS-CoV-2 ; COVID-19 ; Biomarkers ; Serine
    Chemical Substances Sarcosine (Z711V88R5F) ; Biomarkers ; Serine (452VLY9402)
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1341843
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Immunological profiling in long COVID: overall low grade inflammation and T-lymphocyte senescence and increased monocyte activation correlating with increasing fatigue severity.

    Berentschot, Julia C / Drexhage, Hemmo A / Aynekulu Mersha, Daniel G / Wijkhuijs, Annemarie J M / GeurtsvanKessel, Corine H / Koopmans, Marion P G / Voermans, Jolanda J C / Hendriks, Rudi W / Nagtzaam, Nicole M A / de Bie, Maaike / Heijenbrok-Kal, Majanka H / Bek, L Martine / Ribbers, Gerard M / van den Berg-Emons, Rita J G / Aerts, Joachim G J V / Dik, Willem A / Hellemons, Merel E

    Frontiers in immunology

    2023  Volume 14, Page(s) 1254899

    Abstract: ... and depression (>24%). Immune abnormalities that were found in the entire group of long COVID patients ... These abnormalities were present against a background of immune abnormalities common to the entire group of long COVID ... Background: Many patients with SARS-CoV-2 infection develop long COVID with fatigue as one ...

    Abstract Background: Many patients with SARS-CoV-2 infection develop long COVID with fatigue as one of the most disabling symptoms. We performed clinical and immune profiling of fatigued and non-fatigued long COVID patients and age- and sex-matched healthy controls (HCs).
    Methods: Long COVID symptoms were assessed using patient-reported outcome measures, including the fatigue assessment scale (FAS, scores ≥22 denote fatigue), and followed up to one year after hospital discharge. We assessed inflammation-related genes in circulating monocytes, serum levels of inflammation-regulating cytokines, and leukocyte and lymphocyte subsets, including major monocyte subsets and senescent T-lymphocytes, at 3-6 months post-discharge.
    Results: We included 37 fatigued and 36 non-fatigued long COVID patients and 42 HCs. Fatigued long COVID patients represented a more severe clinical profile than non-fatigued patients, with many concurrent symptoms (median 9 [IQR 5.0-10.0] vs 3 [1.0-5.0] symptoms, p<0.001), and signs of cognitive failure (41%) and depression (>24%). Immune abnormalities that were found in the entire group of long COVID patients were low grade inflammation (increased inflammatory gene expression in monocytes, increased serum pro-inflammatory cytokines) and signs of T-lymphocyte senescence (increased exhausted CD8
    Conclusion: Long COVID with fatigue is associated with many concurrent and persistent symptoms lasting up to one year after hospitalization. Increased fatigue severity associated with stronger signs of monocyte activation in long COVID patients and potentially point in the direction of monocyte-endothelial interaction. These abnormalities were present against a background of immune abnormalities common to the entire group of long COVID patients.
    MeSH term(s) Humans ; T-Lymphocytes ; Monocytes ; COVID-19/complications ; Post-Acute COVID-19 Syndrome ; Aftercare ; SARS-CoV-2 ; Patient Discharge ; Fatigue ; Cytokines ; Inflammation/complications
    Chemical Substances Cytokines
    Language English
    Publishing date 2023-10-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1254899
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Increased serum 1,25-dihydroxyvitamin D levels in gynecologic cancer patients with Post-Acute-Covid-Sequela (PASC)/Long COVID.

    Bellone, Stefania / Siegel, Eric E / Santin, Alessandro D

    Gynecologic oncology reports

    2023  Volume 50, Page(s) 101301

    Abstract: Post-acute sequelae of COVID-19 (PASC), also known as Long-Covid (LC), may affect 10-30 % of COVID ... for at least 2 years in patients with long covid symptoms. The active form (1,25OH) but not the storage form ... infected patients, and is characterized by a variety of debilitating symptoms lasting over 3 months after ...

    Abstract Post-acute sequelae of COVID-19 (PASC), also known as Long-Covid (LC), may affect 10-30 % of COVID-infected patients, and is characterized by a variety of debilitating symptoms lasting over 3 months after the acute infection, including but not limited to dyspnea, fatigue, and musculoskeletal, cognitive, and/or mental health impairments. Vitamin D is an essential nutrient primarily recognized for its role in regulating calcium and bone health but also endowed with potent anti-inflammatory activity affecting a variety of immune cells. We retrospectively evaluated the plasmatic levels of both 1,25-dihydroxyvitamin-D (1,25 OH), and 25-hydroxyvitamin-D (25 OH), the active and storage forms of vitamin-D3, respectively, in the serum of gynecologic cancer patients affected by PASC/LC vs control cancer patients. We found elevated 1,25-dihydroxyvitamin-D levels in 5 out of 5 of the PASC/LC patients (mean ± SD = 97.2 ± 26.9 pg/mL) versus 0 out of 10 of randomly selected cancer control patients (44.9 ± 17.2 pg/mL, p = 0.0005). In contrast, no significant difference was noted in the levels of 25-dihydroxyvitamin-D in PASC/LC (mean ± SD = 48.2 ± 15.8 ng/mL) versus controls (43.0 ± 11.6 ng/mL, p = 0.48). Importantly, abnormal levels of vitamin D were found to persist for at least 2 years in patients with long covid symptoms. The active form (1,25OH) but not the storage form (25 OH) of vitamin-D is significantly elevated in PASC/LC cancer patients. Abnormally and persistently elevated 1,25OH levels, similarly to sarcoidosis patients, may represent the results of extrarenal conversion of vitamin D by activated macrophages, and a novel biomarker of persistent inflammation in gynecologic cancer patients with PASC/LC.
    Language English
    Publishing date 2023-11-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2818505-5
    ISSN 2352-5789
    ISSN 2352-5789
    DOI 10.1016/j.gore.2023.101301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Intermittent left bundle branch block with septal flash and postural orthostatic tachycardia syndrome in a young woman with long COVID-19.

    Kitsou, Vasiliki / Blomberg, Bjørn / Lunde, Torbjørn / Saeed, Sahrai

    BMJ case reports

    2022  Volume 15, Issue 6

    Abstract: The emerging entity, long COVID -19 is characterised by long-lasting dyspnoea, fatigue, cognitive ... common in long COVID-19. The direct viral damage to the myocardium or immune-mediated inflammation are ... The echocardiographic findings together with POTS and persistent dyspnoea indicated the presence of a long COVID-19 ...

    Abstract The emerging entity, long COVID -19 is characterised by long-lasting dyspnoea, fatigue, cognitive dysfunction and other symptoms. Cardiac involvement manifested as conduction abnormalities, left ventricle mechanical dyssynchrony, dyspnoea, palpitation and postural orthostatic tachycardia syndrome (POTS) are common in long COVID-19. The direct viral damage to the myocardium or immune-mediated inflammation are postulated mechanisms. A woman in her forties presented with a 2-month history of chest pain, functional dyspnoea, palpitation and an episode of syncope after having been home-isolated for mild COVID infection. During clinical workup, a clustering of ECG and echocardiographic abnormalities including left bundle branch block, septal flash, and presystolic wave on spectral Doppler echocardiography, and POTS were detected. The echocardiographic findings together with POTS and persistent dyspnoea indicated the presence of a long COVID-19 state. The prevalence and clinical significance of these finding, as well as the impact on long-term prognosis, should be investigated in future studies.
    MeSH term(s) Bundle-Branch Block/diagnosis ; COVID-19/complications ; Dyspnea/etiology ; Female ; Humans ; Postural Orthostatic Tachycardia Syndrome/diagnosis
    Language English
    Publishing date 2022-06-07
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-249608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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