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  1. Article ; Online: Intravenous Magnesium for Acute Asthma Exacerbations in Children: To Mag or Not to Mag.

    Tanverdi, Melisa S / Navanandan, Nidhya

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 5, Page(s) 1247–1248

    MeSH term(s) Acute Disease ; Administration, Intravenous ; Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Child ; Humans ; Magnesium/therapeutic use
    Chemical Substances Anti-Asthmatic Agents ; Magnesium (I38ZP9992A)
    Language English
    Publishing date 2022-05-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2022.01.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comparative effectiveness of intravenous and inhaled magnesium in acute asthma.

    Colice, Gene L

    Journal of comparative effectiveness research

    2013  Volume 2, Issue 5, Page(s) 437–441

    Abstract: ... in the management of severe acute asthma exacerbations. Although neither inhaled nor intravenous magnesium achieved ... sulphate versus standard therapy for severe acute asthma (3Mg trial): a double-blind, randomized controlled trial ... Lancet Respir. Med. 1, 293-300 (2013). Acute exacerbations of asthma are common. The current recommended ...

    Abstract Evaluation of: Goodacre S, Cohen J, Bradburn M et al. Intravenous or nebulised magnesium sulphate versus standard therapy for severe acute asthma (3Mg trial): a double-blind, randomized controlled trial. Lancet Respir. Med. 1, 293-300 (2013). Acute exacerbations of asthma are common. The current recommended treatment approach to managing an acute asthma exacerbation is to administer a short-acting inhaled β2-agonist (SABA). SABAs are rapidly effective but may not provide the bronchodilation needed to restore adequate lung function. Consequently, in severe acute asthma exacerbations, despite a standard approach to treatment including SABAs, hospitalization is common. Magnesium is a bronchodilator that may provide additional benefit to SABAs in managing acute asthma exacerbations. In this article, the comparative effectiveness of inhaled and intravenous magnesium in addition to standard therapy is evaluated in the management of severe acute asthma exacerbations. Although neither inhaled nor intravenous magnesium achieved the protocol-specified benefits, intravenous magnesium was associated with fewer hospitalizations and a trend for greater improvement in the symptom of breathlessness than inhaled magnesium.
    MeSH term(s) Asthma/therapy ; Female ; Humans ; Male
    Language English
    Publishing date 2013-09
    Publishing country England
    Document type Comment ; Journal Article
    ISSN 2042-6313
    ISSN (online) 2042-6313
    DOI 10.2217/cer.13.55
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Intravenous magnesium for acute asthma?

    Drug and therapeutics bulletin

    2003  Volume 41, Issue 10, Page(s) 79–80

    Abstract: ... magnesium and whether it offers any advantage for patients with acute severe asthma. ... British Guideline on the Management of Asthma suggests also using a single dose of i.v. magnesium ... sulphate in patients with acute severe asthma, an unlicensed indication. Here we discuss the rationale for giving i.v ...

    Abstract Each year in the UK, around 1,500 people die from asthma. Standard treatment has been based on bronchodilators (e.g. beta 2-stimulants) and anti-inflammatory drugs (corticosteroids). The recently revised British Guideline on the Management of Asthma suggests also using a single dose of i.v. magnesium sulphate in patients with acute severe asthma, an unlicensed indication. Here we discuss the rationale for giving i.v. magnesium and whether it offers any advantage for patients with acute severe asthma.
    MeSH term(s) Acute Disease ; Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Humans ; Injections, Intravenous ; Magnesium Sulfate/therapeutic use ; Randomized Controlled Trials as Topic ; Treatment Outcome
    Chemical Substances Anti-Asthmatic Agents ; Magnesium Sulfate (7487-88-9)
    Language English
    Publishing date 2003-10-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80242-6
    ISSN 1755-5248 ; 0012-6543
    ISSN (online) 1755-5248
    ISSN 0012-6543
    DOI 10.1136/dtb.2003.411079
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Clinical outcomes of children with acute asthma managed with intravenous magnesium sulphate outside intensive care setting.

    Aziz, Danish Abdul / Sajjad, Muhammad Aqib / Iftikhar, Haissan

    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

    2023  

    Abstract: ... in magnesium sulfate (MS) group. Patients receiving all standard acute asthma treatment but were not started ... In poorly controlled asthma, multiple adjunct therapies including magnesium sulphate (MgSO4), are ... patients treated with magnesium sulphate during exacerbations of asthma admitted at a tertiary care unit ...

    Abstract Asthma in children constitutes a well-known respiratory condition with significant mortality. In poorly controlled asthma, multiple adjunct therapies including magnesium sulphate (MgSO4), are recommended to decrease the likelihood of intubation; however, limited evidence exists to support their routine usage in day-to-day situations. Aim of this study is to determine the outcomes of pediatric patients treated with magnesium sulphate during exacerbations of asthma admitted at a tertiary care unit. A retrospective study was conducted at The Aga Khan University Hospital, Karachi, Pakistan from January 2019 to December 2021. Patients aged 6 years to 15 years presented with acute asthma through Emergency Room (ER) having clinical respiratory score (CRS) more than five, admitted in high-dependency unit (HDU) were included in the study. Patients who were started on magnesium sulfate within 24 hours of admission were categorized in magnesium sulfate (MS) group. Patients receiving all standard acute asthma treatment but were not started on magnesium therapy within 24 hours of admission were categorized in the non-magnesium sulfate (non-MS) group. Different outcome variables were compared between the groups. A total of 110 patients with asthma were enrolled. Fifty-four patients were categorized into MS group while 56 were included in non-MS group. Fewer patients were transferred from HDU to pediatric intensive care unit (PICU) (24.07%) in MS group compared to non-MS group (42.85%), (p=0.02). In MS group, the mean number of days spent on oxygen in HDU were 2.38±0.81, while non-MS group spent more days (3.10±0.84 (p<0.01). This study demonstrates that for pediatric patients with severe asthma exacerbations, administration of IV MgSO4 (within 24 hours) is beneficial and results in fewer admissions to PICU and reduces the mean number of days spent on oxygen therapy.
    Language English
    Publishing date 2023-09-12
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1160940-0
    ISSN 1122-0643 ; 1120-0391
    ISSN 1122-0643 ; 1120-0391
    DOI 10.4081/monaldi.2023.2664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Intravenous Magnesium Sulfate for Acute Asthma Exacerbation in Adults.

    Conway, John / Friedman, Benjamin

    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

    2020  Volume 27, Issue 10, Page(s) 1061–1063

    Language English
    Publishing date 2020-08-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1329813-6
    ISSN 1553-2712 ; 1069-6563
    ISSN (online) 1553-2712
    ISSN 1069-6563
    DOI 10.1111/acem.14066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Intravenous magnesium for acute asthma.

    Pugh, G

    Annals of emergency medicine

    1993  Volume 22, Issue 3, Page(s) 617; author reply 618–9

    MeSH term(s) Asthma/drug therapy ; Humans ; Magnesium/therapeutic use ; Randomized Controlled Trials as Topic/standards ; Sampling Studies
    Chemical Substances Magnesium (I38ZP9992A)
    Language English
    Publishing date 1993-03
    Publishing country United States
    Document type Clinical Trial ; Comment ; Letter ; Randomized Controlled Trial
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/s0196-0644(05)81959-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Intravenous magnesium for acute asthma.

    Spivey, W H

    Annals of emergency medicine

    1993  Volume 22, Issue 3, Page(s) 617; author reply 618–9

    MeSH term(s) Asthma/drug therapy ; Ethics Committees ; Humans ; Informed Consent ; Magnesium/therapeutic use
    Chemical Substances Magnesium (I38ZP9992A)
    Language English
    Publishing date 1993-03
    Publishing country United States
    Document type Clinical Trial ; Comment ; Letter ; Randomized Controlled Trial
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/s0196-0644(05)81958-4
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  8. Article: Intravenous magnesium for acute asthma.

    Skobeloff, E M / McNamara, R M

    Annals of emergency medicine

    1993  Volume 22, Issue 3, Page(s) 617–8; author reply 618–9

    MeSH term(s) Asthma/drug therapy ; Humans ; Magnesium/therapeutic use ; Research Design/standards
    Chemical Substances Magnesium (I38ZP9992A)
    Language English
    Publishing date 1993-03
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/s0196-0644(05)81960-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Intravenous magnesium for acute asthma.

    Fesmire, F M

    Annals of emergency medicine

    1993  Volume 22, Issue 3, Page(s) 616–7; author reply 618–9

    MeSH term(s) Adult ; Asthma/drug therapy ; Dose-Response Relationship, Drug ; Female ; Humans ; Injections, Intravenous ; Magnesium/administration & dosage ; Magnesium/blood ; Male ; Middle Aged
    Chemical Substances Magnesium (I38ZP9992A)
    Language English
    Publishing date 1993-03
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/s0196-0644(05)81957-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Intravenous magnesium for acute asthma.

    Jones, E B / Gonzalez, E R

    Annals of emergency medicine

    1993  Volume 22, Issue 3, Page(s) 618; author reply 618–9

    MeSH term(s) Asthma/drug therapy ; Drug Therapy, Combination ; Humans ; Lung Diseases, Obstructive/drug therapy ; Magnesium/therapeutic use ; Research Design/standards
    Chemical Substances Magnesium (I38ZP9992A)
    Language English
    Publishing date 1993-03
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/s0196-0644(05)81961-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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