Article ; Online: Peripheral neuropathy in COVID-19 is due to immune-mechanisms, pre-existing risk factors, anti-viral drugs, or bedding in the Intensive Care Unit.
2021 Volume 79, Issue 10, Page(s) 924–928
Abstract: ... with COVID-19 is frequent and predominantly due to immune mechanisms or neurotoxic side effects of drugs used ... nerves resulting from prolonged bedding in the Intensive Care Unit (ICU) and pre-existing risk factors ... frequent and mostly result from immune mechanisms or neurotoxic side effects of drugs used to treat ...
| Abstract | Background: This mini-review aims to summarize and discuss previous and recent advances in the clinical presentation, pathophysiology, diagnosis, treatment, and outcome of SARS-CoV-2-associated peripheral neuropathies. Methods: Literature review. Results: Altogether, 105 articles about SARS-CoV-2-associated neuropathy describing 261 patients were retrieved. Peripheral neuropathy in patients with COVID-19 is frequent and predominantly due to immune mechanisms or neurotoxic side effects of drugs used to treat the symptoms of COVID-19 and, to a lesser extent, due to the compression of peripheral nerves resulting from prolonged bedding in the Intensive Care Unit (ICU) and pre-existing risk factors such as diabetes. SARS-CoV-2 does not cause viral neuropathy. Neurotoxic drugs such as daptomycin, linezolid, lopinavir, ritonavir, hydro-chloroquine, cisatracurium, clindamycin, and glucocorticoids should be administered with caution and patients should be appropriately bedded in the ICU to prevent SARS-CoV-2-associated neuropathy. Patients with Guillain-Barré syndrome (GBS) benefit from immunoglobulins, plasma exchange, and steroids. Conclusions: Neuropathies of peripheral nerves in patients with COVID-19 are frequent and mostly result from immune mechanisms or neurotoxic side effects of drugs used to treat the symptoms of COVID-19 and, to a lesser extent, from the compression of peripheral nerves due to prolonged bedding on the ICU. SARS-CoV-2 does not cause infectious neuropathy. |
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| MeSH term(s) | Antiviral Agents ; Bedding and Linens ; COVID-19 ; Guillain-Barre Syndrome/chemically induced ; Humans ; Intensive Care Units ; Peripheral Nervous System Diseases/chemically induced ; Pharmaceutical Preparations ; Risk Factors ; SARS-CoV-2 |
| Chemical Substances | Antiviral Agents ; Pharmaceutical Preparations |
| Language | English |
| Publishing date | 2021-07-21 |
| Publishing country | Brazil |
| Document type | Journal Article ; Review |
| ZDB-ID | 418916-4 |
| ISSN | 1678-4227 ; 0004-282X |
| ISSN (online) | 1678-4227 |
| ISSN | 0004-282X |
| DOI | 10.1590/0004-282X-ANP-2021-0030 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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