Article ; Online: Symptoms and recovery among adult outpatients with and without COVID-19 at 11 healthcare facilities-July 2020, United States.
Influenza and other respiratory viruses
2021 Volume 15, Issue 3, Page(s) 345–351
Abstract: ... with 11 medical centers in the United States were interviewed to assess symptoms, illness duration, and ... Background: Symptoms of mild COVID-19 illness are non-specific and may persist for prolonged ... are not well understood.: Methods: Adults aged ≥18 years with laboratory-confirmed COVID-19 and ...
| Abstract | Background: Symptoms of mild COVID-19 illness are non-specific and may persist for prolonged periods. Effects on quality of life of persistent poor physical or mental health associated with COVID-19 are not well understood. Methods: Adults aged ≥18 years with laboratory-confirmed COVID-19 and matched control patients who tested negative for SARS-CoV-2 infection at outpatient facilities associated with 11 medical centers in the United States were interviewed to assess symptoms, illness duration, and health-related quality of life. Duration of symptoms, health-related quality of life measures, and days of poor physical health by symptoms experienced during illness were compared between case patients and controls using Wilcoxon rank-sum tests. Symptoms associated with COVID-19 case status were evaluated by multivariable logistic regression. Results: Among 320 participants included, 157 were COVID-19 cases and 163 were SARS-CoV-2 negative controls. Loss of taste or smell was reported by 63% of cases and 6% of controls and was strongly associated with COVID-19 in logistic regression models (adjusted odds ratio [aOR] = 32.4; 95% confidence interval [CI], 12.6-83.1). COVID-19 cases were more likely than controls to have experienced fever, body aches, weakness, or fatigue during illness, and to report ≥1 persistent symptom more than 14 days after symptom onset (50% vs 32%, P < .001). Cases reported significantly more days of poor physical health during the past 14 days than controls (P < .01). Conclusions: Differentiating COVID-19 from other acute illnesses will require widespread diagnostic testing, especially during influenza seasons. Persistent COVID-19-related symptoms may negatively affect quality of life, even among those initially presenting with mild illness. |
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| MeSH term(s) | Adult ; COVID-19/psychology ; Case-Control Studies ; Female ; Health Facilities ; Humans ; Logistic Models ; Male ; Middle Aged ; Outpatients ; Quality of Life ; SARS-CoV-2 | |||||
| Language | English | |||||
| Publishing date | 2021-01-06 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 2274538-5 | |||||
| ISSN | 1750-2659 ; 1750-2640 | |||||
| ISSN (online) | 1750-2659 | |||||
| ISSN | 1750-2640 | |||||
| DOI | 10.1111/irv.12832 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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