Article ; Online: Molecular Insights into the Thrombotic and Microvascular Injury in Placental Endothelium of Women with Mild or Severe COVID-19.
2021 Volume 10, Issue 2
Abstract: ... of placentas from women with severe COVID-19 but not in those with mild disease. Placental histological ... in the endothelium of decidua and chorionic villi of placentas derived from women with COVID-19, being higher ... vascular endothelial (VE) cadherin in the decidua and chorionic villi of placentas from women with mild and severe ...
| Abstract | Clinical manifestations of coronavirus disease 2019 (COVID-19) in pregnant women are diverse, and little is known of the impact of the disease on placental physiology. Severe acute respiratory syndrome coronavirus (SARS-CoV-2) has been detected in the human placenta, and its binding receptor ACE2 is present in a variety of placental cells, including endothelium. Here, we analyze the impact of COVID-19 in placental endothelium, studying by immunofluorescence the expression of von Willebrand factor (vWf), claudin-5, and vascular endothelial (VE) cadherin in the decidua and chorionic villi of placentas from women with mild and severe COVID-19 in comparison to healthy controls. Our results indicate that: (1) vWf expression increases in the endothelium of decidua and chorionic villi of placentas derived from women with COVID-19, being higher in severe cases; (2) Claudin-5 and VE-cadherin expression decrease in the decidua and chorionic villus of placentas from women with severe COVID-19 but not in those with mild disease. Placental histological analysis reveals thrombosis, infarcts, and vascular wall remodeling, confirming the deleterious effect of COVID-19 on placental vessels. Together, these results suggest that placentas from women with COVID-19 have a condition of leaky endothelium and thrombosis, which is sensitive to disease severity. |
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| MeSH term(s) | Adult ; Antigens, CD/analysis ; COVID-19/complications ; COVID-19/pathology ; COVID-19/virology ; Cadherins/analysis ; Claudin-5/analysis ; Endothelium/blood supply ; Endothelium/pathology ; Endothelium/virology ; Female ; Humans ; Infant, Newborn ; Microvessels/pathology ; Microvessels/virology ; Placenta/blood supply ; Placenta/pathology ; Pregnancy ; Pregnancy Complications, Cardiovascular/etiology ; Pregnancy Complications, Cardiovascular/pathology ; Pregnancy Complications, Cardiovascular/virology ; Pregnancy Complications, Infectious/etiology ; Pregnancy Complications, Infectious/pathology ; Pregnancy Complications, Infectious/virology ; SARS-CoV-2/isolation & purification ; Thrombosis/etiology ; Thrombosis/pathology ; Thrombosis/virology ; Young Adult ; von Willebrand Factor/analysis |
| Chemical Substances | Antigens, CD ; CLDN5 protein, human ; Cadherins ; Claudin-5 ; cadherin 5 ; von Willebrand Factor |
| Language | English |
| Publishing date | 2021-02-10 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2661518-6 |
| ISSN | 2073-4409 ; 2073-4409 |
| ISSN (online) | 2073-4409 |
| ISSN | 2073-4409 |
| DOI | 10.3390/cells10020364 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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