Article ; Online: Interferon Lambda Upregulates IDO1 Expression in Respiratory Epithelial Cells After Influenza Virus Infection.
2015 Volume 35, Issue 7, Page(s) 554–562
Abstract: ... in IDO regulation was investigated after influenza infection of respiratory epithelial cells. IDO1 ... affected in respiratory epithelial cells during influenza infection. In this study, the role of IFN-λ ... to express IDO but during influenza infection, IDO is primarily expressed in uninfected cells. These studies ...
| Abstract | Influenza infection causes an increase in indoleamine 2, 3-dioxygenase (IDO) activity in the lung parenchyma. IDO catabolizes tryptophan into kynurenine, leading to immune dampening. Multiple cell types express IDO, and while IFN-γ upregulates IDO in dendritic cells and macrophages, it is unclear how IDO is affected in respiratory epithelial cells during influenza infection. In this study, the role of IFN-λ in IDO regulation was investigated after influenza infection of respiratory epithelial cells. IDO1 expression increased concurrently with IFN-λ expression. In differentiated NHBE cells, the IDO metabolite was released basolaterally. Recombinant IFN-λ upregulated IDO1 activity, and silencing of IFN-λ decreased IDO1 expression during influenza infection. During IFN-λ stimulation, most differentiated cell types are able to express IDO but during influenza infection, IDO is primarily expressed in uninfected cells. These studies show a role for IDO in the host response to influenza infection, and they provide insights into novel approaches for enhancing vaccine responses and therapeutic approaches. |
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| MeSH term(s) | Animals ; Cell Death ; Cell Line ; Cell Survival ; Cytokines/metabolism ; Dogs ; Epithelial Cells/enzymology ; Epithelial Cells/virology ; Humans ; Indoleamine-Pyrrole 2,3,-Dioxygenase/antagonists & inhibitors ; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism ; Influenza, Human/metabolism ; Influenza, Human/virology ; Interferons ; Interleukins/metabolism ; Lung/pathology ; Mice ; Orthomyxoviridae Infections/metabolism ; Orthomyxoviridae Infections/virology ; Up-Regulation ; Viral Load | |||||
| Chemical Substances | Cytokines ; IDO1 protein, human ; IDO1 protein, mouse ; interferon-lambda, human ; Indoleamine-Pyrrole 2,3,-Dioxygenase ; Interleukins ; interferon-lambda protein, mouse ; Interferons (9008-11-1) | |||||
| Language | English | |||||
| Publishing date | 2015-03-10 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 1226675-9 | |||||
| ISSN | 1557-7465 ; 1079-9907 | |||||
| ISSN (online) | 1557-7465 | |||||
| ISSN | 1079-9907 | |||||
| DOI | 10.1089/jir.2014.0052 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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