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Article ; Online: Chest CT score in COVID-19 patients: correlation with disease severity and short-term prognosis.

Francone, Marco / Iafrate, Franco / Masci, Giorgio Maria / Coco, Simona / Cilia, Francesco / Manganaro, Lucia / Panebianco, Valeria / Andreoli, Chiara / Colaiacomo, Maria Chiara / Zingaropoli, Maria Antonella / Ciardi, Maria Rosa / Mastroianni, Claudio Maria / Pugliese, Francesco / Alessandri, Francesco / Turriziani, Ombretta / Ricci, Paolo / Catalano, Carlo

European radiology

2020 Volume 30, Issue 12, Page(s) 6808–6817

Abstract: ... symptomatic SARS-CoV-2 patients were enrolled for this single-center analysis and chest CT examinations were ... severity of clinical categories, and disease phases. • A CT score ≥ 18 has shown to be highly predictive ... of patient's mortality in short-term follow-up. • Our multivariate analysis demonstrated that CT parenchymal ...

Abstract	Objectives: To correlate a CT-based semi-quantitative score of pulmonary involvement in COVID-19 pneumonia with clinical staging of disease and laboratory findings. We also aimed to investigate whether CT findings may be predictive of patients' outcome. Methods: From March 6 to March 22, 2020, 130 symptomatic SARS-CoV-2 patients were enrolled for this single-center analysis and chest CT examinations were retrospectively evaluated. A semi-quantitative CT score was calculated based on the extent of lobar involvement (0:0%; 1, < 5%; 2:5-25%; 3:26-50%; 4:51-75%; 5, > 75%; range 0-5; global score 0-25). Data were matched with clinical stages and laboratory findings. Survival curves and univariate and multivariate analyses were performed to evaluate the role of CT score as a predictor of patients' outcome. Results: Ground glass opacities were predominant in early-phase (≤ 7 days since symptoms' onset), while crazy-paving pattern, consolidation, and fibrosis characterized late-phase disease (> 7 days). CT score was significantly higher in critical and severe than in mild stage (p < 0.0001), and among late-phase than early-phase patients (p < 0.0001). CT score was significantly correlated with CRP (p < 0.0001, r = 0.6204) and D-dimer (p < 0.0001, r = 0.6625) levels. A CT score of ≥ 18 was associated with an increased mortality risk and was found to be predictive of death both in univariate (HR, 8.33; 95% CI, 3.19-21.73; p < 0.0001) and multivariate analysis (HR, 3.74; 95% CI, 1.10-12.77; p = 0.0348). Conclusions: Our preliminary data suggest the potential role of CT score for predicting the outcome of SARS-CoV-2 patients. CT score is highly correlated with laboratory findings and disease severity and might be beneficial to speed-up diagnostic workflow in symptomatic cases. Key points: • CT score is positively correlated with age, inflammatory biomarkers, severity of clinical categories, and disease phases. • A CT score ≥ 18 has shown to be highly predictive of patient's mortality in short-term follow-up. • Our multivariate analysis demonstrated that CT parenchymal assessment may more accurately reflect short-term outcome, providing a direct visualization of anatomic injury compared with non-specific inflammatory biomarkers.
MeSH term(s)	Adult ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Female ; Humans ; Italy/epidemiology ; Lung/diagnostic imaging ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Prognosis ; Retrospective Studies ; SARS-CoV-2 ; Severity of Illness Index ; Tomography, X-Ray Computed/methods
Keywords	covid19
Language	English
Publishing date	2020-07-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-020-07033-y
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Article ; Online: Chest CT score in COVID-19 patients. Correlation with disease severity and short-term prognosis

Francone, M. / Iafrate, F. / Masci, G. M. / Coco, S. / Cilia, F. / Manganaro, L. / Panebianco, V. / Andreoli, C. / Colaiacomo, M. C. / Zingaropoli, M. A. / Ciardi, M. R. / Mastroianni, C. M. / Pugliese, F. / Alessandri, F. / Turriziani, O. / Ricci, P. / Catalano, C.

2020

Abstract: ... SARS-CoV-2 patients were enrolled for this single-center analysis and chest CT examinations were ... of clinical categories, and disease phases. • A CT score ≥ 18 has shown to be highly predictive of patient’s ... Objectives: To correlate a CT-based semi-quantitative score of pulmonary involvement in COVID-19 ...

Abstract	Objectives: To correlate a CT-based semi-quantitative score of pulmonary involvement in COVID-19 pneumonia with clinical staging of disease and laboratory findings. We also aimed to investigate whether CT findings may be predictive of patients’ outcome. Methods: From March 6 to March 22, 2020, 130 symptomatic SARS-CoV-2 patients were enrolled for this single-center analysis and chest CT examinations were retrospectively evaluated. A semi-quantitative CT score was calculated based on the extent of lobar involvement (0:0%; 1, < 5%; 2:5–25%; 3:26–50%; 4:51–75%; 5, > 75%; range 0–5; global score 0–25). Data were matched with clinical stages and laboratory findings. Survival curves and univariate and multivariate analyses were performed to evaluate the role of CT score as a predictor of patients’ outcome. Results: Ground glass opacities were predominant in early-phase (≤ 7days since symptoms’ onset), while crazy-paving pattern, consolidation, and fibrosis characterized late-phase disease (> 7days). CT score was significantly higher in critical and severe than in mild stage (p < 0.0001), and among late-phase than early-phase patients (p < 0.0001). CT score was significantly correlated with CRP (p < 0.0001, r = 0.6204) and D-dimer (p < 0.0001, r = 0.6625) levels. A CT score of ≥ 18 was associated with an increased mortality risk and was found to be predictive of death both in univariate (HR, 8.33; 95% CI, 3.19–21.73; p < 0.0001) and multivariate analysis (HR, 3.74; 95% CI, 1.10–12.77; p = 0.0348). Conclusions: Our preliminary data suggest the potential role of CT score for predicting the outcome of SARS-CoV-2 patients. CT score is highly correlated with laboratory findings and disease severity and might be beneficial to speed-up diagnostic workflow in symptomatic cases. Key Points: • CT score is positively correlated with age, inflammatory biomarkers, severity of clinical categories, and disease phases. • A CT score ≥ 18 has shown to be highly predictive of patient’s mortality in short-term follow-up. • Our multivariate analysis demonstrated that CT parenchymal assessment may more accurately reflect short-term outcome, providing a direct visualization of anatomic injury compared with non-specific inflammatory biomarkers.
Keywords	covid-19 ; pneumonia ; severe acute respiratory syndrome coronavirus 2 ; tomography ; x-ray computed ; covid19
Subject code	616 ; 610
Language	English
Publisher	Springer
Publishing country	it
Document type	Article ; Online
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Article: Chest CT score in COVID-19 patients: correlation with disease severity and short-term prognosis

Eur Radiol

Abstract: ... SARS-CoV-2 patients were enrolled for this single-center analysis and chest CT examinations were ... severity of clinical categories, and disease phases. â¢ A CT score ≥ 18 has shown to be highly ... predictive of patient's mortality in short-term follow-up. â¢ Our multivariate analysis demonstrated that CT ...

Abstract	OBJECTIVES: To correlate a CT-based semi-quantitative score of pulmonary involvement in COVID-19 pneumonia with clinical staging of disease and laboratory findings. We also aimed to investigate whether CT findings may be predictive of patients' outcome. METHODS: From March 6 to March 22, 2020, 130 symptomatic SARS-CoV-2 patients were enrolled for this single-center analysis and chest CT examinations were retrospectively evaluated. A semi-quantitative CT score was calculated based on the extent of lobar involvement (0:0%; 1, < 5%; 2:5-25%; 3:26-50%; 4:51-75%; 5, > 75%; range 0-5; global score 0-25). Data were matched with clinical stages and laboratory findings. Survival curves and univariate and multivariate analyses were performed to evaluate the role of CT score as a predictor of patients' outcome. RESULTS: Ground glass opacities were predominant in early-phase (≤ 7 days since symptoms' onset), while crazy-paving pattern, consolidation, and fibrosis characterized late-phase disease (> 7 days). CT score was significantly higher in critical and severe than in mild stage (p < 0.0001), and among late-phase than early-phase patients (p < 0.0001). CT score was significantly correlated with CRP (p < 0.0001, r = 0.6204) and D-dimer (p < 0.0001, r = 0.6625) levels. A CT score of ≥ 18 was associated with an increased mortality risk and was found to be predictive of death both in univariate (HR, 8.33; 95% CI, 3.19-21.73; p < 0.0001) and multivariate analysis (HR, 3.74; 95% CI, 1.10-12.77; p = 0.0348). CONCLUSIONS: Our preliminary data suggest the potential role of CT score for predicting the outcome of SARS-CoV-2 patients. CT score is highly correlated with laboratory findings and disease severity and might be beneficial to speed-up diagnostic workflow in symptomatic cases. KEY POINTS: â¢ CT score is positively correlated with age, inflammatory biomarkers, severity of clinical categories, and disease phases. â¢ A CT score ≥ 18 has shown to be highly predictive of patient's mortality in short-term follow-up. â¢ Our multivariate analysis demonstrated that CT parenchymal assessment may more accurately reflect short-term outcome, providing a direct visualization of anatomic injury compared with non-specific inflammatory biomarkers.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #629489
Database	COVID19

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Article ; Online: Correlation between chest CT severity scores and clinical and biochemical parameters of COVID-19 pneumonia.

Komurcuoglu, Berna / Susam, Seher / Batum, Özgür / Turk, Merve A / Salik, Bilge / Karadeniz, Gulistan / Senol, Gunes

The clinical respiratory journal

2022 Volume 16, Issue 7, Page(s) 497–503

Abstract: ... in the chest diseases clinic because of COVID-19 pneumonia between 11.03.2020 and 31.05.2020 were evaluated ... patients who have a score of 15 and above with semiquantitative scoring risky in terms of poor prognosis ... the severity and prognosis of the disease in correlation with clinical and laboratory parameters. Considering ...

Abstract	Background: The COVID-19 pandemic, which first appeared in Wuhan, China, in December 2019 and spread rapidly around the globe, continues to be a serious threat today. Rapid and accurate diagnostic methods are needed to identify, isolate and treat patients as soon as possible because of the rapid contagion of COVID-19. In the present study, the relation of the semi-quantitative scoring method with computed tomography in the diagnosis of COVID-19 in determining the severity of the disease with clinical and laboratory parameters and survival of the patients were investigated along with its value in prognostic prediction. Material and method: A total of 277 adult patients who were followed up in the chest diseases clinic because of COVID-19 pneumonia between 11.03.2020 and 31.05.2020 were evaluated retrospectively in the present study. Both lungs were divided into five regions in line with their anatomical structures, and semiquantitative radiological scoring was made between 0 and 25 points according to the distribution of lesions in each region. The relations between semiquantitative radiological score and age, gender, comorbidity, and clinical and laboratory parameters were examined. Results: A significant correlation was detected between advanced age, lymphopenia, low oxygen saturation, high ferritin, D-dimer, and radiological score in the univariate analysis performed in the present study. The cut-off value of the semiquantitative radiology score was found to be 15 (AUC: 0.615, 95% CI: 0.554-0.617, p = 0.106) in ROC analysis. The survival was found to be better in cases with a radiology score below 15, in Kaplan-Meier analysis (HR: 4.71, 95% CI: 1.43-15.46, p < 0.01). In the radiological score and nonparametric correlation analyses, positive correlations were detected between CRP, D-dimer, AST, LDH, ferritin, and pro-BNP, and a negative correlation was found between partial oxygen pressure and oxygen saturation (p = 0.01, r = 0.321/0.313/0.362/0.343/0.313/0.333/-0.235/-0.231, respectively) CONCLUSION: It was found that the scoring system that was calculated quantitatively in thorax HRCTs in Covid-19 patients is a predictive actor in determining the severity and prognosis of the disease in correlation with clinical and laboratory parameters. Considering patients who have a score of 15 and above with semiquantitative scoring risky in terms of poor prognosis and short survival and close follow-up and early treatment may be effective to reduce mortality rates.
MeSH term(s)	Adult ; COVID-19/diagnostic imaging ; COVID-19/pathology ; Ferritins ; Humans ; Pandemics ; Prognosis ; Retrospective Studies ; Severity of Illness Index ; Thorax ; Tomography, X-Ray Computed
Chemical Substances	Ferritins (9007-73-2)
Language	English
Publishing date	2022-06-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2442214-9
ISSN	1752-699X ; 1752-6981
ISSN (online)	1752-699X
ISSN	1752-6981
DOI	10.1111/crj.13515
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Article ; Online: Chest CT score in COVID-19 patients

European Radiology ; ISSN 0938-7994 1432-1084

correlation with disease severity and short-term prognosis

2020

Keywords	Radiology Nuclear Medicine and imaging ; General Medicine ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
DOI	10.1007/s00330-020-07033-y
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A novel chest CT severity score in COVID-19 and its correlation with severity and prognosis of the lung disease: A retrospective cohort study.

Younus, Shifa / Maqsood, Hamza / Sattar, Abdul / Younas, Amna / Shakeel, Hassan Abdullah

Annals of medicine and surgery (2012)

2022 Volume 82, Page(s) 104692

Abstract: ... chest severity score (CT-SS) to evaluate the COVID-19 disease burden on the initial scan obtained ... CT scoring system might aid in the risk stratification and the short-term prognostication of patients ... CT severity score, a novel parameter designed for risk stratification and prognostication of COVID-19 ...

Abstract	Background: HRCT chest has a high sensitivity in the diagnosis of patients with COVID-19 infection. Through our study, we intend to evaluate the diagnostic accuracy and inter-reader variability of a semi-quantitative CT severity score, a novel parameter designed for risk stratification and prognostication of COVID-19 pneumonia with clinical staging of disease. Methods: It was a single-center retrospective analysis performed on an original cohort of 4180 symptomatic patients with the suspicion of SARS-CoV-2 interstitial pneumonia. Out of 4180, a total of 4004 patients with COVID-19 were confirmed by an RT-PCR. We used an HRCT chest severity score (CT-SS) to evaluate the COVID-19 disease burden on the initial scan obtained at admission. The data were analyzed with IBM SPSS Statistics Version 22.0 Release 2013. Results: Our study subjects demonstrated the most common clinical features fever, cough, dyspnea, and body aches. Raised CRP levels (CRP >0.5 mg/dL) were found in 81.86% and increased D-dimer levels (>500 ng/mL) were found in 92.3% of patients. The most common radiological findings of the disease included ground-glass opacities, observed in 98.8%. Our study has a sensitivity of 89.2%, a specificity of 94.8%, a positive predictive value (PPV) of 90.6%, and a negative predictive value (NPV) of 94%. Conclusion: As per our findings, this novel CT scoring system might aid in the risk stratification and the short-term prognostication of patients suffering from COVID-19 pneumonia. This will eventually help in curtailing the extensive burden on the healthcare system amid the current pandemic.
Language	English
Publishing date	2022-09-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2022.104692
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Article ; Online: Correlation between the initial CT chest findings and short-term prognosis in Egyptian patients with COVID-19 pneumonia

Mohamed Mohamed Hefeda / Dalia Ezzat Elsharawy / Tamer Mahmoud Dawoud

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 53, Iss 1, Pp 1-

2022 Volume 17

Abstract: ... CT finding and the short-term prognosis in 320 patients. Results All patients had confirmed COVID-19 ... finding and disease severity or the short-term prognosis was reported. The mean age was higher ... with COVID-19 pneumonia in Egypt including the mean severity score and also correlation between the initial ...

Abstract	Abstract Background The recent pandemic of COVID‐19 has thrown the world into chaos due to its high rate of transmissions. This study aimed to highlight the encountered CT findings in 910 patients with COVID-19 pneumonia in Egypt including the mean severity score and also correlation between the initial CT finding and the short-term prognosis in 320 patients. Results All patients had confirmed COVID-19 infection. Non-contrast CT chest was performed for all cases; in addition, the correlation between each CT finding and disease severity or the short-term prognosis was reported. The mean age was higher for patients with unfavorable prognosis (P < 0.01). The patchy pattern was the most common, found in 532/910 patients (58.4%), the nodular pattern was the least common 123/910 (13.5%). The diffuse pattern was reported in 124 (13.6%). The ground glass density was the most common reported density in the study 512/910 (56.2%). The crazy pavement sign was reported more frequently in patients required hospitalization or ICU and was reported in 53 (56.9%) of patients required hospitalization and in 29 (40.2%) patients needed ICU, and it was reported in 11 (39.2%) deceased patients. Air bronchogram was reported more frequently in patients with poor prognosis than patients with good prognosis (16/100; 26% Vs 12/220; 5.4%). The mean CT severity score for patients with poor prognosis was 15.2. The mean CT severity score for patients with good prognosis 8.7., with statistically significant difference (P = 0.001). Conclusion Our results confirm the important role of the initial CT findings in the prediction of clinical outcome and short-term prognosis. Some signs like subpleural lines, halo sign, reversed halo sign and nodular shape of the lesions predict mild disease and favorable prognosis. The crazy paving sign, dense vessel sign, consolidation, diffuse shape and high severity score predict more severe disease and probably warrant early hospitalization. The high severity score is most important in prediction of ...
Keywords	COVOD-19 ; COVID-19 chest CT ; COVID-19 pneumonia ; COVID-19 prognosis ; COVID-19 CT severity score ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chest CT manifestations with emphasis on the role of CT scoring and serum ferritin/lactate dehydrogenase in prognosis of coronavirus disease 2019 (COVID-19)

Rehab Abdel Rahman El Bakry / Ayman Ibrahim Tharwat Sayed

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 52, Iss 1, Pp 1-

2021 Volume 12

Abstract: ... Chest CT score, serum ferritin, and serum LDH help in predicting the short-term outcome of the patients ... findings and chest CT scoring along with serum ferritin and LDH in the prognosis of COVID-19 patients ... COVID-19) a pandemic, and because of the primary pulmonary manifestations of the disease, chest CT is ...

Abstract	Abstract Background In March 2020, the World Health Organization announced coronavirus disease 2019 (COVID-19) a pandemic, and because of the primary pulmonary manifestations of the disease, chest CT is essential in the evaluation of those patients. The aim of the study was to evaluate the role of chest CT findings and chest CT scoring along with serum ferritin and LDH in the prognosis of COVID-19 patients in a cohort of the Egyptian population. Results This retrospective study included 250 patients with positive RT-PCR for COVID-19, 138 males [55.2%] and 112 females [44.8%], age range 17–82 years with median 49.5. Two hundred patients had a positive significant correlation between age, serum ferritin, serum LDH, and CT score. Bilateral affection was 88% while unilaterality was 12%, and peripheral chest CT findings were stratified as follows: mild [score from 1 to 10], 114 patients [57%]; moderate [score from 11 to 19], 65 patients [32.5%]; and severe [score from 20 to 25], 21 patients [10.5%]. In severe cases, males constitute 85.7% while females were only 14.3%. Statistical and central distribution was 67%, peripheral was 31%, and central was 2%. Ground glass opacity (GGO) was the highest pattern 39.2%, consolidation 31.2%, fibrosis 15.2%, and CP 13.7%, with lymph nodes only 0.6%. Fifteen cases [6%] were critical; all showed severe scores ranging from 21 to 23 with three times increase in serum ferritin and four times increase in LDH. A follow-up study done to 8 cases [3.2%] showed an increase in CT scoring, serum ferritin, and serum LDH. Conclusion Chest CT findings are crucial for early diagnosis of COVID-19 disease especially for asymptomatic patients with old age and male sex considered risk factors for poor prognosis. Chest CT score, serum ferritin, and serum LDH help in predicting the short-term outcome of the patients aiming to decrease both morbidity and mortality.
Keywords	Coronavirus ; COVID-19 ; Chest CT ; Ferritin ; LDH ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610 ; 616
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Chest CT score in COVID-19 patients: correlation with disease severity and short-term prognosis.

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Article: Chest CT score in COVID-19 patients: correlation with disease severity and short-term prognosis

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Article ; Online: Correlation between chest CT severity scores and clinical and biochemical parameters of COVID-19 pneumonia.

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Article ; Online: Chest CT score in COVID-19 patients

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Article: A novel chest CT severity score in COVID-19 and its correlation with severity and prognosis of the lung disease: A retrospective cohort study.

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Article ; Online: Correlation between the initial CT chest findings and short-term prognosis in Egyptian patients with COVID-19 pneumonia

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Article ; Online: Chest CT manifestations with emphasis on the role of CT scoring and serum ferritin/lactate dehydrogenase in prognosis of coronavirus disease 2019 (COVID-19)

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