Article ; Online: 2019 novel coronavirus disease with secondary ischemic stroke: two case reports.
BMC neurology
2021 Volume 21, Issue 1, Page(s) 4
Abstract: ... presentation: We here report two cases of coronavirus-infected pneumonia with acute ischemic stroke ... occlusion. The patients were diagnosed with coronavirus diseases with secondary acute ischemic stroke ... These cases suggested that secondary ischemic stroke, mainly manifested as small-vessel occlusion, should be ...
| Abstract | Background: The COVID-19 pandemic, which broke out in Wuhan in 2019, has become the global health crisis of our time. Elderly patients with certain fundamental diseases are more likely to develop severe cases. The secondary lesion following viral infection have only rarely been reported. Case presentation: We here report two cases of coronavirus-infected pneumonia with acute ischemic stroke in middle-aged patients. In both COVID-19 cases, neurological physical examinations showed normal results before infection. Lymphocytopenia, accompanied by elevated cytokines and D-dimers, were found from serum clinical laboratory examination at admission. Dysarthria and limb muscle weakness are initial manifestations, occurring one week after infect-causative pathogen, SARS-CoV-2. The head CT and head/neck arterial CTA showed small-vessel occlusion. The patients were diagnosed with coronavirus diseases with secondary acute ischemic stroke. They were treated with tirofiban and followed up with daily aspirin and atorvastatin. Conclusions: These cases suggested that secondary ischemic stroke, mainly manifested as small-vessel occlusion, should be considered for COVID-19 patients and diagnosed and treated promptly. |
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| MeSH term(s) | Aspirin/therapeutic use ; Atorvastatin/therapeutic use ; Brain Ischemia/drug therapy ; Brain Ischemia/etiology ; COVID-19/complications ; Fibrinolytic Agents/therapeutic use ; Humans ; Ischemic Stroke/drug therapy ; Ischemic Stroke/etiology ; Male ; Middle Aged ; Pandemics ; SARS-CoV-2 ; Tirofiban/therapeutic use |
| Chemical Substances | Fibrinolytic Agents ; Atorvastatin (A0JWA85V8F) ; Tirofiban (GGX234SI5H) ; Aspirin (R16CO5Y76E) |
| Language | English |
| Publishing date | 2021-01-05 |
| Publishing country | England |
| Document type | Case Reports ; Journal Article |
| ISSN | 1471-2377 |
| ISSN (online) | 1471-2377 |
| DOI | 10.1186/s12883-020-02033-3 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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