Article: Malignant astrocytic glioma: genetics, biology, and paths to treatment.
2007 Volume 21, Issue 21, Page(s) 2683–2710
Abstract: ... of the mechanisms underlying the genetics, biology and clinical behavior of glioblastoma. This progress is fueling ... tissue, and certain death. The recent confluence of advances in stem cell biology, cell signaling, genome ... Malignant astrocytic gliomas such as glioblastoma are the most common and lethal intracranial ...
| Abstract | Malignant astrocytic gliomas such as glioblastoma are the most common and lethal intracranial tumors. These cancers exhibit a relentless malignant progression characterized by widespread invasion throughout the brain, resistance to traditional and newer targeted therapeutic approaches, destruction of normal brain tissue, and certain death. The recent confluence of advances in stem cell biology, cell signaling, genome and computational science and genetic model systems have revolutionized our understanding of the mechanisms underlying the genetics, biology and clinical behavior of glioblastoma. This progress is fueling new opportunities for understanding the fundamental basis for development of this devastating disease and also novel therapies that, for the first time, portend meaningful clinical responses. |
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| MeSH term(s) | Animals ; Animals, Genetically Modified ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Astrocytoma/genetics ; Astrocytoma/pathology ; Astrocytoma/therapy ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Brain Neoplasms/therapy ; Disease Models, Animal ; Gene Regulatory Networks ; Humans ; Models, Biological ; Necrosis/chemically induced ; Neoplasm Invasiveness ; Neoplasm Staging ; Neovascularization, Pathologic/drug therapy | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2007-11-01 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review | ||||||||||
| ZDB-ID | 806684-x | ||||||||||
| ISSN | 1549-5477 ; 0890-9369 | ||||||||||
| ISSN (online) | 1549-5477 | ||||||||||
| ISSN | 0890-9369 | ||||||||||
| DOI | 10.1101/gad.1596707 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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