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  1. Article: ACE2 expression and sex disparity in COVID-19.

    Gagliardi, Maria Cristina / Tieri, Paolo / Ortona, Elena / Ruggieri, Anna

    Cell death discovery

    2020  Volume 6, Page(s) 37

    Keywords covid19
    Language English
    Publishing date 2020-05-26
    Publishing country United States
    Document type Journal Article
    ISSN 2058-7716
    ISSN 2058-7716
    DOI 10.1038/s41420-020-0276-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: ACE2 expression and sex disparity in COVID-19

    Gagliardi, Maria Cristina / Tieri, Paolo / Ortona, Elena / Ruggieri, Anna

    Cell Death Discovery

    2020  Volume 6, Issue 1

    Keywords covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ISSN 2058-7716
    DOI 10.1038/s41420-020-0276-1
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: ACE2 expression and sex disparity in COVID-19

    Maria Cristina Gagliardi / Paolo Tieri / Elena Ortona / Anna Ruggieri

    Cell Death Discovery, Vol 6, Iss 1, Pp 1-

    2020  Volume 2

    Keywords Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Cytology ; QH573-671 ; covid19
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Could Sex/Gender Differences in ACE2 Expression in the Lungs Contribute to the Large Gender Disparity in the Morbidity and Mortality of Patients Infected With the SARS-CoV-2 Virus?

    Majdic, Gregor

    Frontiers in cellular and infection microbiology

    2020  Volume 10, Page(s) 327

    Abstract: ... this could theoretically explain the gender disparity in COVID-19 disease. More importantly, although modulation of ACE2 ... will certainly not provide a cure for the COVID-19 disease, modulation of ACE2 by sex hormone modulators ... COVID-19 morbidity and mortality have significant gender disparities, with higher prevalence and ...

    Abstract COVID-19 morbidity and mortality have significant gender disparities, with higher prevalence and mortality in men. SARS-CoV-2 enters the lungs through the ACE2 enzyme, a member of the renin-angiotensin system (RAS). Although there are no data for the lung, the expressions of RAS components in other tissues are modulated by sex hormones, androgens, and estrogens. However, there are no data on sex-specific differences in ACE2 expression. If there is a sex difference in the expression of ACE2 in the lung, this could theoretically explain the gender disparity in COVID-19 disease. More importantly, although modulation of ACE2 will certainly not provide a cure for the COVID-19 disease, modulation of ACE2 by sex hormone modulators, if they affect the expression of ACE2, could potentially be developed into a supportive therapy for COVID-19 patients.
    MeSH term(s) Androgens/blood ; Angiotensin-Converting Enzyme 2 ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Coronavirus Infections/pathology ; Estrogens/blood ; Female ; Humans ; Lung/metabolism ; Male ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/pathology ; SARS-CoV-2 ; Sex Distribution ; Sex Factors
    Chemical Substances Androgens ; Estrogens ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-06-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2020.00327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Expression of ACE2, the SARS-CoV-2 receptor, and TMPRSS2 in prostate epithelial cells.

    Song, Hanbing / Seddighzadeh, Bobak / Cooperberg, Matthew R / Huang, Franklin W

    2020  

    Abstract: The COVID-19 pandemic has spread across more than 200 countries and resulted in over 170,000 deaths ... also found club cells co-expressing TMPRSS2 and ACE2. A comparison of ACE2 expression in lung tissue ... types showed the highest expression of ACE2. These results raise the possibility that sex ...

    Abstract The COVID-19 pandemic has spread across more than 200 countries and resulted in over 170,000 deaths. For unclear reasons, higher mortality rates from COVID-19 have been reported in men compared to women. While the SARS-CoV-2 receptor ACE2 and serine protease TMPRSS2 have been detected in lung and other tissues, it is not clear what sex differences may exist. We analyzed a publicly-available normal human prostate single-cell RNA sequencing dataset and found TMPRSS2 and ACE2 co-expressing cells in epithelial cells, with a higher proportion in club and hillock cells. Then we investigated datasets of lung epithelial cells and also found club cells co-expressing TMPRSS2 and ACE2. A comparison of ACE2 expression in lung tissue between males and females showed higher expression in males and a larger proportion of ACE2+ cells in male type II pneumocytes, with preliminary evidence that type II pneumocytes of all lung epithelial cell types showed the highest expression of ACE2. These results raise the possibility that sex differences in ACE2 expression and the presence of double-positive cells in the prostate may contribute to the observed disparities of COVID-19.
    Keywords ACE2 ; COVID-19 ; SARS-CoV-2 ; TMPRSS2 ; lung ; prostate ; sex ; covid19
    Subject code 570
    Publishing date 2020-04-25
    Publisher eScholarship, University of California
    Publishing country us
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Expression of ACE2, the SARS-CoV-2 receptor, and TMPRSS2 in prostate epithelial cells

    Song, Hanbing / Seddighzadeh, Bobak / Cooperberg, Matthew R / Huang, Franklin W

    bioRxiv

    Abstract: The COVID-19 pandemic has spread across more than 200 countries and resulted in over 170,000 deaths ... also found club cells co-expressing TMPRSS2 and ACE2. A comparison of ACE2 expression in lung tissue ... types showed the highest expression of ACE2. These results raise the possibility that sex ...

    Abstract The COVID-19 pandemic has spread across more than 200 countries and resulted in over 170,000 deaths. For unclear reasons, higher mortality rates from COVID-19 have been reported in men compared to women. While the SARS-CoV-2 receptor ACE2 and serine protease TMPRSS2 have been detected in lung and other tissues, it is not clear what sex differences may exist. We analyzed a publicly-available normal human prostate single-cell RNA sequencing dataset and found TMPRSS2 and ACE2 co-expressing cells in epithelial cells, with a higher proportion in club and hillock cells. Then we investigated datasets of lung epithelial cells and also found club cells co-expressing TMPRSS2 and ACE2. A comparison of ACE2 expression in lung tissue between males and females showed higher expression in males and a larger proportion of ACE2+ cells in male type II pneumocytes, with preliminary evidence that type II pneumocytes of all lung epithelial cell types showed the highest expression of ACE2. These results raise the possibility that sex differences in ACE2 expression and the presence of double-positive cells in the prostate may contribute to the observed disparities of COVID-19.
    Keywords covid19
    Language English
    Publishing date 2020-04-25
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2020.04.24.056259
    Database COVID19

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  8. Article ; Online: Could Sex/Gender Differences in ACE2 Expression in the Lungs Contribute to the Large Gender Disparity in the Morbidity and Mortality of Patients Infected With the SARS-CoV-2 Virus?

    Gregor Majdic

    Frontiers in Cellular and Infection Microbiology, Vol

    2020  Volume 10

    Abstract: ... this could theoretically explain the gender disparity in COVID-19 disease. More importantly, although modulation of ACE2 ... will certainly not provide a cure for the COVID-19 disease, modulation of ACE2 by sex hormone modulators ... COVID-19 morbidity and mortality have significant gender disparities, with higher prevalence and ...

    Abstract COVID-19 morbidity and mortality have significant gender disparities, with higher prevalence and mortality in men. SARS-CoV-2 enters the lungs through the ACE2 enzyme, a member of the renin-angiotensin system (RAS). Although there are no data for the lung, the expressions of RAS components in other tissues are modulated by sex hormones, androgens, and estrogens. However, there are no data on sex-specific differences in ACE2 expression. If there is a sex difference in the expression of ACE2 in the lung, this could theoretically explain the gender disparity in COVID-19 disease. More importantly, although modulation of ACE2 will certainly not provide a cure for the COVID-19 disease, modulation of ACE2 by sex hormone modulators, if they affect the expression of ACE2, could potentially be developed into a supportive therapy for COVID-19 patients.
    Keywords lung ; ACE2 ; COVID 19 ; sex difference ; androgens ; Microbiology ; QR1-502 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Could Sex/Gender Differences in ACE2 Expression in the Lungs Contribute to the Large Gender Disparity in the Morbidity and Mortality of Patients Infected With the SARS-CoV-2 Virus?

    Majdic, Gregor

    Front Cell Infect Microbiol

    Abstract: ... this could theoretically explain the gender disparity in COVID-19 disease. More importantly, although modulation of ACE2 ... will certainly not provide a cure for the COVID-19 disease, modulation of ACE2 by sex hormone modulators ... COVID-19 morbidity and mortality have significant gender disparities, with higher prevalence and ...

    Abstract COVID-19 morbidity and mortality have significant gender disparities, with higher prevalence and mortality in men. SARS-CoV-2 enters the lungs through the ACE2 enzyme, a member of the renin-angiotensin system (RAS). Although there are no data for the lung, the expressions of RAS components in other tissues are modulated by sex hormones, androgens, and estrogens. However, there are no data on sex-specific differences in ACE2 expression. If there is a sex difference in the expression of ACE2 in the lung, this could theoretically explain the gender disparity in COVID-19 disease. More importantly, although modulation of ACE2 will certainly not provide a cure for the COVID-19 disease, modulation of ACE2 by sex hormone modulators, if they affect the expression of ACE2, could potentially be developed into a supportive therapy for COVID-19 patients.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #615468
    Database COVID19

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