Article ; Online: Is the Collapse of the Respiratory Center in the Brain Responsible for Respiratory Breakdown in COVID-19 Patients?
ACS chemical neuroscience
2020 Volume 11, Issue 10, Page(s) 1379–1381
Abstract: ... might infect the respiratory center of brain, which could be accountable for the respiratory breakdown of COVID-19 patients ... Therefore, it is important to screen the COVID-19 patients for neurological symptoms as well as possibility ... of the collapse of the respiratory center in the brainstem should be investigated in depth. ...
| Abstract | Following the identification of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, we are now again facing a global highly pathogenic novel coronavirus (SARS-CoV-2) epidemic. Although the lungs are one of the most critically affected organs, several other organs, including the brain may also get infected. Here, we have highlighted that SARS-CoV-2 might infect the central nervous system (CNS) through the olfactory bulb. From the olfactory bulb, SARS-CoV-2 may target the deeper parts of the brain including the thalamus and brainstem by trans-synaptic transfer described for many other viral diseases. Following this, the virus might infect the respiratory center of brain, which could be accountable for the respiratory breakdown of COVID-19 patients. Therefore, it is important to screen the COVID-19 patients for neurological symptoms as well as possibility of the collapse of the respiratory center in the brainstem should be investigated in depth. |
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| MeSH term(s) | Animals ; Betacoronavirus/isolation & purification ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/physiopathology ; Coronavirus Infections/virology ; Disease Models, Animal ; Humans ; Mice ; Mice, Transgenic ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/virology ; Respiration Disorders/physiopathology ; Respiration Disorders/virology ; Respiratory Center/physiopathology ; Respiratory Center/virology ; Severe acute respiratory syndrome-related coronavirus/pathogenicity ; SARS-CoV-2 |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-04-29 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ISSN | 1948-7193 |
| ISSN (online) | 1948-7193 |
| DOI | 10.1021/acschemneuro.0c00217 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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