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  1. Article ; Online: Anti-HLA and anti-SARS-CoV-2 antibodies in kidney transplant recipients with COVID-19.

    Gandolfini, Ilaria / Zanelli, Paola / Palmisano, Alessandra / Salvetti, Daniel / Parmigiani, Alice / Maltzman, Jonathan S / Labate, Claudia / Fiaccadori, Enrico / Cravedi, Paolo / Maggiore, Umberto

    Transplant international : official journal of the European Society for Organ Transplantation

    2021  Volume 34, Issue 3, Page(s) 596–599

    MeSH term(s) Adult ; Aged ; COVID-19/immunology ; Female ; Follow-Up Studies ; HLA Antigens/immunology ; Humans ; Kidney Transplantation ; Male ; Middle Aged ; Postoperative Complications/immunology ; SARS-CoV-2/immunology ; Transplantation Immunology
    Chemical Substances HLA Antigens
    Language English
    Publishing date 2021-02-26
    Publishing country England
    Document type Letter
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.1111/tri.13829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2358: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Anti-human leukocyte antigen and anti-ABO antibodies after SARS-CoV-2 mRNA vaccination in kidney transplant recipients.

    Nishida, Hayato / Takai, Satoshi / Ito, Hiromi / Fukuhara, Hiroki / Nawano, Takaaki / Narisawa, Takafumi / Kanno, Hidenori / Yagi, Mayu / Yamagishi, Atsushi / Sakurai, Toshihiko / Naito, Sei / Tsuchiya, Norihiko

    Clinical transplantation

    2023  Volume 37, Issue 5, Page(s) e14952

    Abstract: ... leukocyte antigen (HLA) antibodies and anti- ABO blood type antibodies (ABOAb) in kidney transplant ... leukocyte antigen antibodies (DSA), and kidney allograft function before and after vaccination were ... Introduction: In this study, we evaluated whether SARS-CoV-2 mRNA vaccines induce anti-human ...

    Abstract Introduction: In this study, we evaluated whether SARS-CoV-2 mRNA vaccines induce anti-human leukocyte antigen (HLA) antibodies and anti- ABO blood type antibodies (ABOAb) in kidney transplant recipients (KTRs).
    Methods: Sixty-three adult KTRs with functioning grafts who received two doses of the SARS-CoV-2 mRNA vaccine were enrolled in this cohort. Changes in anti-ABO blood type immunoglobulin IgM and IgG antibody titers, flow panel reactive antibody (PRA), de novo donor-specific anti-human leukocyte antigen antibodies (DSA), and kidney allograft function before and after vaccination were evaluated.
    Results: Only one patient experienced conversion from negative to positive flow PRA after vaccination. However, there was no DSA in single antigen flow-bead assays. The mean fluorescence intensity (MFI) in the eight DSA-positive recipients did not significantly change before and after vaccination (p = .383), and no additional DSA was produced after vaccination in those patients. No significant elevation of ABOAb titer was observed for either IgM (p = .438) or IgG (p = .526) after vaccination. There was no significant deterioration in estimated glomerular filtration rate (eGFR) after vaccination (p = .877) or elevation of the urine protein-to-creatinine ratio (p = .209) after vaccination. One episode of AMR was observed in addition to a preexisting acute cellular rejection.
    Conclusions: The SARS-CoV-2 mRNA vaccine did not induce anti-HLA antibody or ABOAb production in KTRs.
    MeSH term(s) Adult ; Humans ; Antibodies, Viral ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; HLA Antigens/immunology ; Immunoglobulin M ; Kidney Transplantation ; RNA, Messenger/genetics ; SARS-CoV-2 ; Transplant Recipients ; Vaccination/adverse effects
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines ; HLA Antigens ; Immunoglobulin M ; RNA, Messenger
    Language English
    Publishing date 2023-03-06
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.14952
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2204: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: SARS-CoV-2 mRNA vaccination is not associated with the induction of anti-HLA or non-HLA antibodies.

    Wijtvliet, Veerle P W M / Verheyden, Sonja / Depreter, Barbara / Heylen, Christine / Coeman, Elke / Abrams, Steven / De Winter, Benedicte Y / Massart, Annick / Hellemans, Rachel / Pipeleers, Lissa / Claas, Frans H J / Ariën, Kevin K / Wissing, Karl Martin / Abramowicz, Daniel / Ledeganck, Kristien J

    Transplant immunology

    2022  Volume 74, Page(s) 101670

    Abstract: Background: SARS-CoV-2 vaccination is strongly recommended in kidney transplant recipients (KTR ... association has been found for anti-non-HLA ARHGDIB antibodies and long-term kidney graft loss. No ... BNT162b2 or mRNA-1273 vaccine. Both anti-HLA and anti-non-HLA antibodies were determined prior ...

    Abstract Background: SARS-CoV-2 vaccination is strongly recommended in kidney transplant recipients (KTR) and dialysis patients. Whether these vaccinations may trigger alloantibodies, is still debated.
    Methods: In the current study we evaluated the effect of SARS-CoV-2 mRNA vaccines on anti-Human Leukocyte Antigen (HLA) and 60 anti-non-HLA antibody profiles in clinically stable KTR and dialysis patients. In total, we included 28 KTR, 30 patients on haemodialysis, 25 patients on peritoneal dialysis and 31 controls with a positive seroresponse 16-21 days after the first dose of either the SARS-CoV-2 mRNA BNT162b2 or mRNA-1273 vaccine. Both anti-HLA and anti-non-HLA antibodies were determined prior to vaccination and 21 to 35 days after the second vaccine dose.
    Results: Overall, the proportion of patients with detectable anti-HLA antibodies was similar before and after vaccination (class I 14% vs. 16%, p = 0.48; class II 25% before and after vaccination). After vaccination, there was no pattern in 1) additionally detected anti-HLA antibodies, or 2) the levels of pre-existing ones. Additional anti-non-HLA antibodies were detected in 30% of the patients, ranging from 1 to 5 new anti-non-HLA antibodies per patient. However, the clinical significance of anti-non-HLA antibodies is still a matter of debate. To date, only a significant association has been found for anti-non-HLA ARHGDIB antibodies and long-term kidney graft loss. No additionally developed anti-ARHGDIB antibodies or elevated level of existing anti-ARHGDIB antibodies was observed.
    Conclusion: The current data indicate that SARS-CoV-2 mRNA vaccination does not induce anti-HLA or anti-non-HLA antibodies, corroborating the importance of vaccinating KTR and dialysis patients.
    MeSH term(s) 2019-nCoV Vaccine mRNA-1273 ; Antibodies, Viral ; BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19 Vaccines ; Graft Rejection ; HLA Antigens/genetics ; Histocompatibility Antigens ; Histocompatibility Antigens Class I ; Histocompatibility Antigens Class II ; Humans ; RNA, Messenger ; Renal Dialysis ; SARS-CoV-2 ; Vaccination ; rho Guanine Nucleotide Dissociation Inhibitor beta
    Chemical Substances ARHGDIB protein, human ; Antibodies, Viral ; COVID-19 Vaccines ; HLA Antigens ; Histocompatibility Antigens ; Histocompatibility Antigens Class I ; Histocompatibility Antigens Class II ; RNA, Messenger ; rho Guanine Nucleotide Dissociation Inhibitor beta ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2022-07-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1160846-8
    ISSN 1878-5492 ; 0966-3274
    ISSN (online) 1878-5492
    ISSN 0966-3274
    DOI 10.1016/j.trim.2022.101670
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3784: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Analysis of Cross-sectional and Longitudinal HLA and Anti-viral Responses After COVID Infection in Renal Allograft Recipients: Differences and Correlates.

    Girnita, Alin L / Wang, Lin / Colovai, Adriana I / Ahearn, Patrick / Azzi, Yorg / Menon, Madhav C / Fernandez-Vina, Marcelo / Gebel, Howard M / Steve Woodle, E / Cravedi, Paolo / Maltzman, Jonathan S / Akalin, Enver

    Transplantation

    2022  Volume 106, Issue 10, Page(s) 2085–2091

    Abstract: ... DSA]), 12 (26%) had non-DSA anti-HLA antibodies and 45 (98%) had anti-SARS-CoV-2 antibodies. Most DSAs ... Anti-HLA antibody strength and calculated panel reactive antibody in kidney transplant recipients after ... 2 (anti-SARS-CoV-2) immune globulin isotypes in organ transplant recipients after coronavirus ...

    Abstract Background: Characterization of anti-HLA versus anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) immune globulin isotypes in organ transplant recipients after coronavirus disease 2019 (COVID-19) infection has not been reported. We aimed to determine changes in anti-HLA antibodies in renal transplant patients with COVID-19 and compare the immunoglobulin and epitope-binding pattern versus anti-SARS-CoV-2 antibodies.
    Methods: This is a cross-sectional study of 46 kidney transplant recipients including 21 with longitudinal sampling. Using a semi-quantitative multiplex assay, we determined immunoglobulin (Ig) M, IgA, IgG, and IgG1-2-3-4 antibodies against Class I and Class II HLA, and 5 SARS-CoV-2 epitopes including the nucleocapsid protein and multiple regions of the spike protein.
    Results: Fourteen of 46 (30%) patients had donor-specific anti-HLA antibodies (donor-specific antibody [DSA]), 12 (26%) had non-DSA anti-HLA antibodies and 45 (98%) had anti-SARS-CoV-2 antibodies. Most DSAs targeted HLA-DQ (71%), with a dominant IgG isotype and IgG1 subtype prevalence (93%), and/or IgG3 (64%), followed by IgG2 (36%). Comparatively, there was a higher prevalence of IgA (85% versus 14%, P = 0.0001) and IgM (87%, versus 36%, P = 0.001) in the anti-SARS-CoV-2 antibody profile, when compared to DSAs, respectively. Anti-SARS-CoV-2 antibody profile was characterized by increased prevalence of IgM and IgA, when compared to DSAs. The median calculated panel reactive antibody before COVID-19 diagnosis (24%) tended to decrease after COVID-19 diagnosis (10%) but it was not statistically significant ( P = 0.1).
    Conclusions: Anti-HLA antibody strength and calculated panel reactive antibody in kidney transplant recipients after COVID-19 do not significantly increase after infection. Although the IgG isotype was the dominant form in both HLA and SARS-CoV-2 antigens, the alloimmune response had a low IgA pattern, whereas anti-SARS-CoV-2 antibodies were high IgA/IgM.
    MeSH term(s) Allografts ; Antibodies, Viral ; COVID-19 ; COVID-19 Testing ; Cross-Sectional Studies ; Epitopes ; HLA Antigens ; HLA-DQ Antigens ; Humans ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; Kidney Transplantation/adverse effects ; Nucleocapsid Proteins ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
    Chemical Substances Antibodies, Viral ; Epitopes ; HLA Antigens ; HLA-DQ Antigens ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; Nucleocapsid Proteins ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 509: Show issues

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