Article ; Online: Rationale and Design of the Awake Prone Position for Early Hypoxemia in COVID-19 Study Protocol: A Clinical Trial.
Annals of the American Thoracic Society
2021 Volume 18, Issue 9, Page(s) 1560–1566
Abstract: ... patients with COVID-19 (APPEX-19 [Awake Prone Position for Early Hypoxemia in COVID-19]). Key innovations ... controlled clinical trial evaluating the safety and effectiveness of awake prone positioning in spontaneously breathing ... disease virulence, and infectivity have created significant barriers to traditional clinical trial practices ...
| Abstract | The unprecedented public health burdens of coronavirus disease (COVID-19) have intensified the urgency of identifying effective, low-cost treatments that limit the need for advanced life support measures and improve clinical outcomes. However, personal protective equipment and staffing shortages, disease virulence, and infectivity have created significant barriers to traditional clinical trial practices. We present the novel design of a pragmatic, adaptive, multicenter, international, prospective randomized controlled clinical trial evaluating the safety and effectiveness of awake prone positioning in spontaneously breathing patients with COVID-19 (APPEX-19 [Awake Prone Position for Early Hypoxemia in COVID-19]). Key innovations of this trial include |
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| MeSH term(s) | Bayes Theorem ; COVID-19 ; Humans ; Hypoxia ; Multicenter Studies as Topic ; Prone Position ; Prospective Studies ; Randomized Controlled Trials as Topic ; SARS-CoV-2 ; Treatment Outcome ; Wakefulness | |||||
| Language | English | |||||
| Publishing date | 2021-03-01 | |||||
| Publishing country | United States | |||||
| Document type | Clinical Trial Protocol ; Journal Article | |||||
| ZDB-ID | 2717461-X | |||||
| ISSN | 2325-6621 ; 1943-5665 ; 2325-6621 | |||||
| ISSN (online) | 2325-6621 ; 1943-5665 | |||||
| ISSN | 2325-6621 | |||||
| DOI | 10.1513/AnnalsATS.202009-1124SD | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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