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Article ; Online: Estimation of Admission D-dimer Cut-off Value to Predict Venous Thrombotic Events in Hospitalized COVID-19 Patients: Analysis of the SEMI-COVID-19 Registry.

García-Cervera, Carles / Giner-Galvañ, Vicente / Wikman-Jorgensen, Philip / Laureiro, Jaime / Rubio-Rivas, Manuel / Gurjian Arena, Anthony / Arnalich-Fernandez, Francisco / Beato Pérez, José Luis / Vargas Núñez, Juan Antonio / González Igual, Jesús Javier / Díez-Manglano, Jesús / Méndez Bailón, Manuel / García Blanco, María José / Freire Castro, Santiago J / Aranda Lobo, Judit / Manzano, Luis / Magallanes Gamboa, Jeffrey Oskar / Arribas Pérez, Luis / González Moraleja, Julio /
Calderón Hernaiz, Ruth / García Alegría, Javier / González Noya, Amara / Gómez Huelgas, Ricardo / Lumbreras Bermejo, Carlos / Antón Santos, Juan Miguel

Journal of general internal medicine

2021  Volume 36, Issue 11, Page(s) 3478–3486

Abstract: Background: Venous thrombotic events (VTE) are frequent in COVID-19, and elevated plasma D-dimer ... retrospective study analyzing the at-admission pDd cut-off value to predict VTE and anticoagulation intensity along ... 189 [148-245] platelets × 10: Conclusions: In hospitalized patients with COVID-19, a pDd value ...

Abstract Background: Venous thrombotic events (VTE) are frequent in COVID-19, and elevated plasma D-dimer (pDd) and dyspnea are common in both entities.
Objective: To determine the admission pDd cut-off value associated with in-hospital VTE in patients with COVID-19.
Methods: Multicenter, retrospective study analyzing the at-admission pDd cut-off value to predict VTE and anticoagulation intensity along hospitalization due to COVID-19.
Results: Among 9386 patients, 2.2% had VTE: 1.6% pulmonary embolism (PE), 0.4% deep vein thrombosis (DVT), and 0.2% both. Those with VTE had a higher prevalence of tachypnea (42.9% vs. 31.1%; p = 0.0005), basal O2 saturation <93% (45.4% vs. 33.1%; p = 0.0003), higher at admission pDd (median [IQR]: 1.4 [0.6-5.5] vs. 0.6 [0.4-1.2] μg/ml; p < 0.0001) and platelet count (median [IQR]: 208 [158-289] vs. 189 [148-245] platelets × 10
Conclusions: In hospitalized patients with COVID-19, a pDd value greater than 3.0 μg/ml can be considered to screen VTE and to consider full-dose anticoagulation.
MeSH term(s) COVID-19 ; Fibrin Fibrinogen Degradation Products ; Hospitalization ; Humans ; Registries ; Retrospective Studies ; SARS-CoV-2 ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/epidemiology ; Venous Thrombosis/diagnosis ; Venous Thrombosis/epidemiology
Chemical Substances Fibrin Fibrinogen Degradation Products ; fibrin fragment D
Language English
Publishing date 2021-07-21
Publishing country United States
Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID 639008-0
ISSN 1525-1497 ; 0884-8734
ISSN (online) 1525-1497
ISSN 0884-8734
DOI 10.1007/s11606-021-07017-8
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