Article ; Online: Estimation of Admission D-dimer Cut-off Value to Predict Venous Thrombotic Events in Hospitalized COVID-19 Patients: Analysis of the SEMI-COVID-19 Registry.
Journal of general internal medicine
2021 Volume 36, Issue 11, Page(s) 3478–3486
Abstract: Background: Venous thrombotic events (VTE) are frequent in COVID-19, and elevated plasma D-dimer ... retrospective study analyzing the at-admission pDd cut-off value to predict VTE and anticoagulation intensity along ... 189 [148-245] platelets × 10: Conclusions: In hospitalized patients with COVID-19, a pDd value ...
Abstract | Background: Venous thrombotic events (VTE) are frequent in COVID-19, and elevated plasma D-dimer (pDd) and dyspnea are common in both entities. Objective: To determine the admission pDd cut-off value associated with in-hospital VTE in patients with COVID-19. Methods: Multicenter, retrospective study analyzing the at-admission pDd cut-off value to predict VTE and anticoagulation intensity along hospitalization due to COVID-19. Results: Among 9386 patients, 2.2% had VTE: 1.6% pulmonary embolism (PE), 0.4% deep vein thrombosis (DVT), and 0.2% both. Those with VTE had a higher prevalence of tachypnea (42.9% vs. 31.1%; p = 0.0005), basal O2 saturation <93% (45.4% vs. 33.1%; p = 0.0003), higher at admission pDd (median [IQR]: 1.4 [0.6-5.5] vs. 0.6 [0.4-1.2] μg/ml; p < 0.0001) and platelet count (median [IQR]: 208 [158-289] vs. 189 [148-245] platelets × 10 Conclusions: In hospitalized patients with COVID-19, a pDd value greater than 3.0 μg/ml can be considered to screen VTE and to consider full-dose anticoagulation. |
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MeSH term(s) | COVID-19 ; Fibrin Fibrinogen Degradation Products ; Hospitalization ; Humans ; Registries ; Retrospective Studies ; SARS-CoV-2 ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/epidemiology ; Venous Thrombosis/diagnosis ; Venous Thrombosis/epidemiology | |||||
Chemical Substances | Fibrin Fibrinogen Degradation Products ; fibrin fragment D | |||||
Language | English | |||||
Publishing date | 2021-07-21 | |||||
Publishing country | United States | |||||
Document type | Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't | |||||
ZDB-ID | 639008-0 | |||||
ISSN | 1525-1497 ; 0884-8734 | |||||
ISSN (online) | 1525-1497 | |||||
ISSN | 0884-8734 | |||||
DOI | 10.1007/s11606-021-07017-8 | |||||
Shelf mark |
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Database | MEDical Literature Analysis and Retrieval System OnLINE |
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