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  1. Article ; Online: Atrial fibrillation in patients with SARS-CoV-2 infection.

    García-Granja, Pablo Elpidio / Veras, Carlos / Aparisi, Álvaro / Amat-Santos, Ignacio J / Catalá, Pablo / Marcos, Marta / Cabezón, Gonzalo / Candela, Jordi / Gil, José Francisco / Uribarri, Aitor / Revilla, Ana / Carrasco, Manuel / Gómez, Itziar / San Román, José Alberto

    Medicina clinica

    2021  Volume 157, Issue 2, Page(s) 58–63

    Abstract: ... Conclusion: Atrial fibrillation appears in 10% of hospitalized patients with SARS-CoV-2 infection ... consecutively admitted in a tertiary hospital due to SARS-CoV-2 infection. We divided the patients in two groups ... multivariable analysis of mortality were also performed.: Results: among 517 patients with SARS-CoV-2 infection ...

    Abstract Introduction and objective: the SARS-CoV-2 infection ranges from asymptomatic to critical forms and several prognostic factors have been described. Atrial fibrillation (AF) is common in acute situations where it is linked with more complications and mortality. We aimed to evaluate the prognostic information of AF in this population.
    Methods: retrospective analysis of a cohort of 517 patients consecutively admitted in a tertiary hospital due to SARS-CoV-2 infection. We divided the patients in two groups according the development of AF and compared the main features of both groups. An univariable and multivariable analysis of mortality were also performed.
    Results: among 517 patients with SARS-CoV-2 infection admitted in a tertiary center, 54 (10.4%) developed AF. These patients are older (81.6 vs 66.5 years old, p<0.001) and present more hypertension (74% vs 47%, p<0.001), cardiomyopathy (9% vs 1%, p=0.002), previous heart failure admission (9% vs 0.4%, p<0.001), previous episodes of AF (83% vs 1%, p<0.001) and bigger left atrium (47.8 vs 39.9mm, p<0.001). AF COVID-19 patients present more acute respiratory failure (72% vs 40%, p<0.001) and higher in-hospital mortality (50% vs 22%, p<0.001). Predictors of AF development are age and previous AF. AF is not an independent predictor of in-hospital mortality. Predictors are age, creatinine>1.5mg/dL at admission, LDH>250UI/L at admission and acute respiratory failure.
    Conclusion: Atrial fibrillation appears in 10% of hospitalized patients with SARS-CoV-2 infection. These patients present more comorbidities and two-fold increase in hospital mortality. Atrial fibrillation is not an independent prognostic factor.
    MeSH term(s) Aged ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/etiology ; COVID-19 ; Hospital Mortality ; Humans ; Retrospective Studies ; Risk Factors ; SARS-CoV-2
    Language Spanish
    Publishing date 2021-01-28
    Publishing country Spain
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2021.01.003
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  2. Article ; Online: Atrial fibrillation in patients with SARS-CoV-2 infection.

    García-Granja, Pablo Elpidio / Veras, Carlos / Aparisi, Álvaro / Amat-Santos, Ignacio J / Catalá, Pablo / Marcos, Marta / Cabezón, Gonzalo / Candela, Jordi / Gil, José Francisco / Uribarri, Aitor / Revilla, Ana / Carrasco, Manuel / Gómez, Itziar / San Román, José Alberto

    Medicina clinica (English ed.)

    2021  Volume 157, Issue 2, Page(s) 58–63

    Abstract: ... Conclusion: Atrial fibrillation appears in 10% of hospitalized patients with SARS-CoV-2 infection ... consecutively admitted in a tertiary hospital due to SARS-CoV-2 infection. We divided the patients in two groups ... multivariable analysis of mortality were also performed.: Results: among 517 patients with SARS-CoV-2 infection ...

    Abstract Introduction and objective: the SARS-CoV-2 infection ranges from asymptomatic to critical forms and several prognostic factors have been described. Atrial fibrillation (AF) is common in acute situations where it is linked with more complications and mortality. We aimed to evaluate the prognostic information of AF in this population.
    Methods: retrospective analysis of a cohort of 517 patients consecutively admitted in a tertiary hospital due to SARS-CoV-2 infection. We divided the patients in two groups according the development of AF and compared the main features of both groups. An univariable and multivariable analysis of mortality were also performed.
    Results: among 517 patients with SARS-CoV-2 infection admitted in a tertiary center, 54 (10.4%) developed AF. These patients are older (81.6 vs 66.5 years old,
    Conclusion: Atrial fibrillation appears in 10% of hospitalized patients with SARS-CoV-2 infection. These patients present more comorbidities and two-fold increase in hospital mortality. Atrial fibrillation is not an independent prognostic factor.
    Language English
    Publishing date 2021-07-19
    Publishing country Spain
    Document type Journal Article
    ISSN 2387-0206
    ISSN (online) 2387-0206
    DOI 10.1016/j.medcle.2021.01.010
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  3. Article ; Online: Prevalence of bleeding secondary to anticoagulation and mortality in patients with atrial fibrillation admitted with SARS-CoV-2 infection.

    Rubini-Costa, Ricardo / Bermúdez-Jiménez, Francisco / Rivera-López, Ricardo / Sola-García, Elena / Nagib-Raya, Hadi / Moreno-Escobar, Eduardo / López-Zúñiga, Miguel Ángel / Briones-Través, Adela / Sanz-Herrera, Francisco / Sequí-Sabater, Jose Miguel / Romero-Cabrera, Juan Luis / Maíllo-Seco, Javier / Fernández-Vázquez, Felipe / Rivadeneira-Ruiz, María / López-Valero, Lucas / Gómez-Navarro, Carlos / Aparicio-Gómez, Jose Antonio / López, Miguel Álvarez / Tercedor, Luis /
    Molina-Jiménez, María / Macías-Ruiz, Rosa / Jiménez-Jáimez, Juan

    Medicina clinica (English ed.)

    2022  Volume 158, Issue 12, Page(s) 569–575

    Abstract: Introduction and purpose: Atrial fibrillation (AF) is common in patients admitted with severe ... 10.6%) vs 3 (2%), : Conclusions: AF patients admitted with COVID-19 represent a population at high ... in these patients. We assessed the anticoagulation and incidence of major cardiovascular events in hospitalized ...

    Abstract Introduction and purpose: Atrial fibrillation (AF) is common in patients admitted with severe COVID-19. However, there is limited data about the management of chronic anticoagulation therapy in these patients. We assessed the anticoagulation and incidence of major cardiovascular events in hospitalized patients with AF and COVID-19.
    Methods: We retrospectively investigated all consecutive patients with AF admitted with COVID-19 between March and May 2020 in 9 Spanish hospitals. We selected a control group of non-AF patients consecutively admitted with COVID-19. We compared baseline characteristics, incidence of major bleeding, thrombotic events and mortality. We used propensity score matching (PSM) to minimize potential confounding variables, as well as a multivariate analysis to predict major bleeding and death.
    Results: 305 patients admitted with AF and COVID-19 were included. After PSM, 151 AF patients were matched with 151 control group patients. During admission, low-molecular-weight heparin was the principal anticoagulant and the incidence of major bleeding and mortality were higher in the AF group [16 (10.6%) vs 3 (2%),
    Conclusions: AF patients admitted with COVID-19 represent a population at high risk for bleeding and mortality during admission. It seems advisable to individualize anticoagulation therapy during admission, considering patient specific bleeding and thrombotic risk.
    Language English
    Publishing date 2022-06-22
    Publishing country Spain
    Document type Journal Article
    ISSN 2387-0206
    ISSN (online) 2387-0206
    DOI 10.1016/j.medcle.2021.06.026
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  4. Article ; Online: Mortality risk factors in patients with SARS-CoV-2 infection and atrial fibrillation: Data from the SEMI-COVID-19 registry.

    Azaña Gómez, Javier / Pérez-Belmonte, Luis M / Rubio-Rivas, Manuel / Bascuñana, José / Quirós-López, Raúl / Taboada Martínez, María Luisa / Montero Hernandez, Esther / Roque-Rojas, Fernando / Méndez-Bailón, Manuel / Gómez-Huelgas, Ricardo

    Medicina clinica (English ed.)

    2022  Volume 159, Issue 10, Page(s) 457–464

    Abstract: ... morbidity and development of complications in patients admitted for COVID-19.: Objectives: To describe ... the clinical, epidemiological, radiological and analytical characteristics of patients with AF admitted ... prognosis of COVID-19 in patients with AF.: Methods: Retrospective, observational, multicenter ...

    Abstract Introduction: Atrial fibrillation and associated comorbidities pose a risk factor for mortality, morbidity and development of complications in patients admitted for COVID-19.
    Objectives: To describe the clinical, epidemiological, radiological and analytical characteristics of patients with AF admitted for COVID-19 in Spain. Secondarily, we aim to identify those variables associated with mortality and poor prognosis of COVID-19 in patients with AF.
    Methods: Retrospective, observational, multicenter, nationwide, retrospective study of patients hospitalized for COVID-19 from March 1 to October 1, 2020. Data were obtained from the SEMI-COVID-19 Registry of the Spanish Society of Internal Medicine (SEMI) in which 150 Spanish hospitals participate.
    Results: Between March 1 and October 1, 2020, data from a total of 16,461 patients were entered into the SEMI-COVID-19 registry. 1,816 (11%) had a history of AF and the number of deaths among AF patients amounted to 738 (41%). Regarding clinical characteristics, deceased patients were admitted with a higher heart rate (88.38 vs 84.95; p > 0.01), with a higher percentage of respiratory failure (67.2% vs 20.1%; p < 0.01) and high tachypnea (58% vs 30%; p < 0.01). The comorbidities that presented statistically significant differences in the deceased group were: age, hypertension and diabetes with target organ involvement. There was also a higher prevalence of a history of cardiovascular disease in the deceased. On multivariate analysis, DOACs treatment had a protective role for mortality (OR:0,597) IC (0,402-0,888

    p = 0.011).
    Conclusions: Previous treatment with DOACs and DOACs treatment during admission seem to have a protective role in patients with AF, although this fact should be verified in prospective studies.
    Language English
    Publishing date 2022-10-13
    Publishing country Spain
    Document type Journal Article
    ISSN 2387-0206
    ISSN (online) 2387-0206
    DOI 10.1016/j.medcle.2022.01.020
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  5. Article ; Online: Mortality risk factors in patients with SARS-CoV-2 infection and atrial fibrillation: Data from the SEMI-COVID-19 registry.

    Azaña Gómez, Javier / Pérez-Belmonte, Luis M / Rubio-Rivas, Manuel / Bascuñana, José / Quirós-López, Raúl / Taboada Martínez, María Luisa / Montero Hernandez, Esther / Roque-Rojas, Fernando / Méndez-Bailón, Manuel / Gómez-Huelgas, Ricardo

    Medicina clinica

    2022  Volume 159, Issue 10, Page(s) 457–464

    Abstract: ... the clinical, epidemiological, radiological and analytical characteristics of patients with atrial fibrillation ... and poor prognosis of COVID-19 in patients with atrial fibrillation.: Methods: Retrospective ... a history of atrial fibrillation and the number of deaths among AF patients amounted to 738 (41%). Regarding ...

    Title translation Factores de riesgo de mortalidad en pacientes con infección por SARS-CoV-2 y fibrilación auricular: datos del registro SEMI-COVID-19.
    Abstract Introduction: Atrial fibrillation and associated comorbidities pose a risk factor for mortality, morbidity and development of complications in patients admitted for COVID-19.
    Objectives: To describe the clinical, epidemiological, radiological and analytical characteristics of patients with atrial fibrillation admitted for COVID-19 in Spain. Secondarily, we aim to identify those variables associated with mortality and poor prognosis of COVID-19 in patients with atrial fibrillation.
    Methods: Retrospective, observational, multicenter, nationwide, retrospective study of patients hospitalized for COVID-19 from March 1 to October 1, 2020. Data were obtained from the SEMI-COVID-19 Registry of the Spanish Society of Internal Medicine (SEMI) in which 150 Spanish hospitals participate.
    Results: Between March 1 and October 1, 2020, data from a total of 16,461 patients were entered into the SEMI-COVID-19 registry. 1816 (11%) had a history of atrial fibrillation and the number of deaths among AF patients amounted to 738 (41%). Regarding clinical characteristics, deceased patients were admitted with a higher heart rate (88.38 vs. 84.95; P>0.01), with a higher percentage of respiratory failure (67.2 vs. 20.1%; P<0.01) and high tachypnea (58 vs. 30%; P<0.01). The comorbidities that presented statistically significant differences in the deceased group were: age, hypertension and diabetes with target organ involvement. There was also a higher prevalence of a history of cardiovascular disease in the deceased. On multivariate analysis, DOACs treatment had a protective role for mortality (OR: 0.597; CI: 0.402-0.888; P=0.011).
    Conclusions: Previous treatment with DOACs and DOACs treatment during admission seem to have a protective role in patients with atrial fibrillation, although this fact should be verified in prospective studies.
    MeSH term(s) Humans ; Atrial Fibrillation/complications ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/drug therapy ; COVID-19/complications ; Retrospective Studies ; Prospective Studies ; SARS-CoV-2 ; Registries ; Risk Factors
    Language Spanish
    Publishing date 2022-03-10
    Publishing country Spain
    Document type Multicenter Study ; Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2022.01.008
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  6. Article ; Online: Prevalence of bleeding secondary to anticoagulation and mortality in patients with atrial fibrillation admitted with SARS-CoV-2 infection.

    Rubini-Costa, Ricardo / Bermúdez-Jiménez, Francisco / Rivera-López, Ricardo / Sola-García, Elena / Nagib-Raya, Hadi / Moreno-Escobar, Eduardo / López-Zúñiga, Miguel Ángel / Briones-Través, Adela / Sanz-Herrera, Francisco / Sequí-Sabater, Jose Miguel / Romero-Cabrera, Juan Luis / Maíllo-Seco, Javier / Fernández-Vázquez, Felipe / Rivadeneira-Ruiz, María / López-Valero, Lucas / Gómez-Navarro, Carlos / Aparicio-Gómez, Jose Antonio / López, Miguel Álvarez / Tercedor, Luis /
    Molina-Jiménez, María / Macías-Ruiz, Rosa / Jiménez-Jáimez, Juan

    Medicina clinica

    2021  Volume 158, Issue 12, Page(s) 569–575

    Abstract: Introduction and purpose: Atrial fibrillation (AF) is common in patients admitted with severe ... in these patients. We assessed the anticoagulation and incidence of major cardiovascular events in hospitalized ... patients with AF and COVID-19.: Methods: We retrospectively investigated all consecutive patients ...

    Abstract Introduction and purpose: Atrial fibrillation (AF) is common in patients admitted with severe COVID-19. However, there is limited data about the management of chronic anticoagulation therapy in these patients. We assessed the anticoagulation and incidence of major cardiovascular events in hospitalized patients with AF and COVID-19.
    Methods: We retrospectively investigated all consecutive patients with AF admitted with COVID-19 between March and May 2020 in 9 Spanish hospitals. We selected a control group of non-AF patients consecutively admitted with COVID-19. We compared baseline characteristics, incidence of major bleeding, thrombotic events and mortality. We used propensity score matching (PSM) to minimize potential confounding variables, as well as a multivariate analysis to predict major bleeding and death.
    Results: 305 patients admitted with AF and COVID-19 were included. After PSM, 151 AF patients were matched with 151 control group patients. During admission, low-molecular-weight heparin was the principal anticoagulant and the incidence of major bleeding and mortality were higher in the AF group [16 (10.6%) vs 3 (2%), p=0.003; 52 (34.4%) vs 35 (23.2%), p=0.03, respectively]. The multivariate analysis showed the presence of AF as independent predictor of in-hospital major bleeding and mortality in COVID-19 patients. In AF group, a secondary multivariate analysis identified high levels of D-dimer as independent predictor of in-hospital major bleeding.
    Conclusions: AF patients admitted with COVID-19 represent a population at high risk for bleeding and mortality during admission. It seems advisable to individualize anticoagulation therapy during admission, considering patient specific bleeding and thrombotic risk.
    MeSH term(s) Anticoagulants/adverse effects ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/epidemiology ; COVID-19/complications ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Humans ; Prevalence ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 ; Thrombosis
    Chemical Substances Anticoagulants
    Language Spanish
    Publishing date 2021-07-15
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2021.06.015
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  7. Article ; Online: Atrial fibrillation is an independent predictor for in-hospital mortality in patients admitted with SARS-CoV-2 infection.

    Mountantonakis, Stavros E / Saleh, Moussa / Fishbein, Joanna / Gandomi, Amir / Lesser, Martin / Chelico, John / Gabriels, James / Qiu, Michael / Epstein, Laurence M

    Heart rhythm

    2021  Volume 18, Issue 4, Page(s) 501–507

    Abstract: ... of AF (55.2% vs 46.8%; P = .009). The risk ratio of in-hospital mortality for new-onset AF in patients ... with worse in-hospital outcomes.: Objective: This study was to determine the incidence of AF in patients ... Methods: Patients hospitalized with a positive COVID-19 polymerase chain reaction test between March 1 ...

    Abstract Background: Atrial fibrillation (AF) is the most encountered arrhythmia and has been associated with worse in-hospital outcomes.
    Objective: This study was to determine the incidence of AF in patients hospitalized with coronavirus disease 2019 (COVID-19) as well as its impact on in-hospital mortality.
    Methods: Patients hospitalized with a positive COVID-19 polymerase chain reaction test between March 1 and April 27, 2020, were identified from the common medical record system of 13 Northwell Health hospitals. Natural language processing search algorithms were used to identify and classify AF. Patients were classified as having AF or not. AF was further classified as new-onset AF vs history of AF.
    Results: AF occurred in 1687 of 9564 patients (17.6%). Of those, 1109 patients (65.7%) had new-onset AF. Propensity score matching of 1238 pairs of patients with AF and without AF showed higher in-hospital mortality in the AF group (54.3% vs 37.2%; P < .0001). Within the AF group, propensity score matching of 500 pairs showed higher in-hospital mortality in patients with new-onset AF as compared with those with a history of AF (55.2% vs 46.8%; P = .009). The risk ratio of in-hospital mortality for new-onset AF in patients with sinus rhythm was 1.56 (95% confidence interval 1.42-1.71; P < .0001). The presence of cardiac disease was not associated with a higher risk of in-hospital mortality in patients with AF (P = .1).
    Conclusion: In patients hospitalized with COVID-19, 17.6% experienced AF. AF, particularly new-onset, was an independent predictor of in-hospital mortality.
    MeSH term(s) Aged ; Aged, 80 and over ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/virology ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/mortality ; Female ; Hospital Mortality ; Hospitalization ; Humans ; Incidence ; Male ; Middle Aged ; Propensity Score ; Retrospective Studies
    Language English
    Publishing date 2021-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2021.01.018
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  8. Article: Atrial Fibrillation and Clinical Outcomes in a Cohort of Hospitalized Patients with Sars-Cov-2 Infection and Chronic Kidney Disease.

    Genovesi, Simonetta / Rebora, Paola / Occhino, Giuseppe / Rossi, Emanuela / Maloberti, Alessandro / Belli, Michele / Bonfanti, Paolo / Giannattasio, Cristina / Rossetti, Claudio / Epis, Oscar Massimiliano / Ughi, Nicola / Valsecchi, Maria Grazia

    Journal of clinical medicine

    2021  Volume 10, Issue 18

    Abstract: ... on in-hospital mortality and on incident atrial fibrillation (AF) in patients infected with SARS-CoV-2. The incidence ... mortality [HR 2.202 (1.728-2.807)]. Incident AF was more frequent in patients with CKD ... mL/min) and in-hospital all-cause mortality and incident AF and AKI. A cohort of 2816 patients ...

    Abstract The aim of the study was to investigate the role of chronic kidney disease (CKD) on in-hospital mortality and on incident atrial fibrillation (AF) in patients infected with SARS-CoV-2. The incidence of acute kidney injury (AKI) was also investigated. Multivariable regression models were used to assess the association between renal function groups (estimated Glomerular Filtration Rate, eGFR, >60 mL/min, 30-59 mL/min, <30 mL/min) and in-hospital all-cause mortality and incident AF and AKI. A cohort of 2816 patients admitted in one year for COVID-19 disease in two large hospitals was analyzed. The independent predictors of mortality were severe CKD [HR 1.732 (95%CI 1.264-2.373)], older age [HR 1.054 (95%CI 1.044-1.065)], cerebrovascular disease [HR 1.335 (95%CI (1.016-1.754)], lower platelet count [HR 0.997 (95%CI 0.996-0.999)], higher C-reactive protein [HR 1.047 (95%CI 1.035-1.058)], and higher plasma potassium value 1.374 (95%CI 1.139-1.658). When incident AKI was added to the final survival model, it was associated with higher mortality [HR 2.202 (1.728-2.807)]. Incident AF was more frequent in patients with CKD, but in the multivariable model only older age was significantly related with a higher incidence of AF [OR 1.036 (95%CI 1.022-1.050)]. Incident AF was strongly associated with the onset of AKI [HR 2.619 (95%CI 1.711-4.009)]. In this large population of COVID-19 patients, the presence of severe CKD was an independent predictor of in-hospital mortality. In addition, patients who underwent AKI during hospitalization had a doubled risk of death. Incident AF became more frequent as eGFR decreased and it was significantly associated with the onset of AKI.
    Language English
    Publishing date 2021-09-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10184108
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  9. Article ; Online: Atrial Fibrillation and Clinical Outcomes in a Cohort of Hospitalized Patients with Sars-Cov-2 Infection and Chronic Kidney Disease

    Simonetta Genovesi / Paola Rebora / Giuseppe Occhino / Emanuela Rossi / Alessandro Maloberti / Michele Belli / Paolo Bonfanti / Cristina Giannattasio / Claudio Rossetti / Oscar Massimiliano Epis / Nicola Ughi / Maria Grazia Valsecchi

    Journal of Clinical Medicine, Vol 10, Iss 4108, p

    2021  Volume 4108

    Abstract: ... on in-hospital mortality and on incident atrial fibrillation (AF) in patients infected with SARS-CoV-2. The incidence ... mortality [HR 2.202 (1.728–2.807)]. Incident AF was more frequent in patients with CKD ... mL/min) and in-hospital all-cause mortality and incident AF and AKI. A cohort of 2816 patients ...

    Abstract The aim of the study was to investigate the role of chronic kidney disease (CKD) on in-hospital mortality and on incident atrial fibrillation (AF) in patients infected with SARS-CoV-2. The incidence of acute kidney injury (AKI) was also investigated. Multivariable regression models were used to assess the association between renal function groups (estimated Glomerular Filtration Rate, eGFR, >60 mL/min, 30–59 mL/min, <30 mL/min) and in-hospital all-cause mortality and incident AF and AKI. A cohort of 2816 patients admitted in one year for COVID-19 disease in two large hospitals was analyzed. The independent predictors of mortality were severe CKD [HR 1.732 (95%CI 1.264–2.373)], older age [HR 1.054 (95%CI 1.044–1.065)], cerebrovascular disease [HR 1.335 (95%CI (1.016–1.754)], lower platelet count [HR 0.997 (95%CI 0.996–0.999)], higher C-reactive protein [HR 1.047 (95%CI 1.035–1.058)], and higher plasma potassium value 1.374 (95%CI 1.139–1.658). When incident AKI was added to the final survival model, it was associated with higher mortality [HR 2.202 (1.728–2.807)]. Incident AF was more frequent in patients with CKD, but in the multivariable model only older age was significantly related with a higher incidence of AF [OR 1.036 (95%CI 1.022–1.050)]. Incident AF was strongly associated with the onset of AKI [HR 2.619 (95%CI 1.711–4.009)]. In this large population of COVID-19 patients, the presence of severe CKD was an independent predictor of in-hospital mortality. In addition, patients who underwent AKI during hospitalization had a doubled risk of death. Incident AF became more frequent as eGFR decreased and it was significantly associated with the onset of AKI.
    Keywords COVID-19 ; chronic kidney disease ; atrial fibrillation ; mortality ; acute kidney injury ; Medicine ; R
    Subject code 616 ; 610
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  10. Article: Atrial fibrillation in a child with multisystem inflammatory syndrome in children.

    Sheriff, Abraar / Rashid, Asrar / Hazeem, Anas Abu / Ismail, Javed / Zeyada, Abdulrahman Ahmed

    Annals of pediatric cardiology

    2023  Volume 16, Issue 2, Page(s) 131–133

    Abstract: ... MIS-C) associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A 10 ... year-old boy with a history of SARS-CoV-2 infection 10 weeks before presentation developed AF following ... Atrial fibrillation (AF) is a rare complication of multisystem inflammatory syndrome in children ...

    Abstract Atrial fibrillation (AF) is a rare complication of multisystem inflammatory syndrome in children (MIS-C) associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A 10-year-old boy with a history of SARS-CoV-2 infection 10 weeks before presentation developed AF following the onset of MIS-C. The patient presented with high fever, conjunctival congestion, erythematous throat, and a diffuse erythematous macular rash involving the face and both legs, in addition to respiratory distress and shock requiring oxygen and vasopressor support. Echocardiography revealed poor left ventricular contractility and normal-appearing coronary vessels. The patient received intravenous immunoglobulin, pulse methylprednisolone, and aspirin. AF resolved with synchronized cardioversion and the patient's clinical condition subsequently improved. This case reports a rare phenomenon of AF in a case of MIS-C. Further research is required to verify the association.
    Language English
    Publishing date 2023-08-16
    Publishing country India
    Document type Case Reports
    ZDB-ID 2430956-4
    ISSN 0974-5149 ; 0974-2069
    ISSN (online) 0974-5149
    ISSN 0974-2069
    DOI 10.4103/apc.apc_2_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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