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  1. Article ; Online: Evaluation and treatment of patients with systemic hypertension.

    Garg, Jay / Messerli, Adrian W / Bakris, George L

    Circulation

    2002  Volume 105, Issue 21, Page(s) 2458–2461

    MeSH term(s) Adrenergic beta-Antagonists/therapeutic use ; Aged ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Antihypertensive Agents/adverse effects ; Antihypertensive Agents/therapeutic use ; Blood Pressure/drug effects ; Calcium Channel Blockers/therapeutic use ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Diabetes Complications ; Disease Management ; Humans ; Hypertension/complications ; Hypertension/diagnosis ; Hypertension/therapy ; Kidney Diseases/complications ; Kidney Diseases/diagnosis ; Kidney Diseases/therapy ; Life Style ; Male ; Practice Guidelines as Topic ; Risk Factors
    Chemical Substances Adrenergic beta-Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Antihypertensive Agents ; Calcium Channel Blockers
    Language English
    Publishing date 2002-05-28
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/01.cir.0000017143.59204.aa
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  2. Article ; Online: TIPS: indications, Contraindications, and Evaluation.

    Carroll, Allison / Boike, Justin R

    Current gastroenterology reports

    2023  Volume 25, Issue 10, Page(s) 232–241

    Abstract: ... hepatic encephalopathy, opening TIPS to a larger patient population. Overall, with newer stent technology and more ... and evaluation for TIPS. In the last three decades of use, there have been substantial changes and ... Purpose of review: This review summarizes the current and emerging indications, contraindications ...

    Abstract Purpose of review: This review summarizes the current and emerging indications, contraindications, and evaluation for TIPS. In the last three decades of use, there have been substantial changes and progress in this field, including the use of controlled-expansion, covered stents, which has broadened the clinical uses of TIPS.
    Recent findings: Recent findings have rapidly expanded the indications for TIPS, including emerging uses in hepatorenal syndrome, hepatopulmonary syndrome and before abdominal surgery. The widespread use of controlled-expansion, covered stents has decreased rates of post-TIPS hepatic encephalopathy, opening TIPS to a larger patient population. Overall, with newer stent technology and more research in this area, the clinical utility and potential of TIPS has rapidly expanded. Going forward, a renewed focus on randomized-control trials and long-term outcomes will be a crucial element to selecting appropriate TIPS recipients and recommending emerging indications for this procedure.
    MeSH term(s) Humans ; Hypertension, Portal ; Hepatic Encephalopathy ; Stents ; Contraindications ; Treatment Outcome ; Portasystemic Shunt, Transjugular Intrahepatic/methods ; Ascites/surgery ; Esophageal and Gastric Varices ; Gastrointestinal Hemorrhage
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2041376-2
    ISSN 1534-312X ; 1522-8037
    ISSN (online) 1534-312X
    ISSN 1522-8037
    DOI 10.1007/s11894-023-00884-7
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  3. Article ; Online: Resistant hypertension: Diagnosis, evaluation, and treatment practical approach.

    Parodi, Roberto / Brandani, Laura / Romero, César / Klein, Manuel

    European journal of internal medicine

    2024  Volume 123, Page(s) 23–28

    Abstract: ... True RH is considered when appropriate lifestyle measures and treatment with optimal or best tolerated ... patients are at a high risk of cardiovascular events and death. RH is associated with a higher prevalence ... evidence of adherence to therapy and exclusion of secondary causes of hypertension are required. RH ...

    Abstract The term RH describes a subgroup of hypertensive patients whose BP is uncontrolled despite the use of at least three antihypertensive drugs in an appropriate combination at optimal or best tolerated doses. True RH is considered when appropriate lifestyle measures and treatment with optimal or best tolerated doses of three or more drugs (a thiazide/thiazide-like diuretic, plus renin-angiotensin system -RAS- blocker and a calcium channel blocker -CCB-) fail to lower office BP to <140/90 mmHg; besides the inadequate BP control should be confirmed by home blood pressure monitoring (HBPM) or 24-hour ambulatory; and evidence of adherence to therapy and exclusion of secondary causes of hypertension are required. RH patients are at a high risk of cardiovascular events and death. RH is associated with a higher prevalence of end-organ damage. When stricter criteria are applied, a reasonable estimate of the prevalence of true RH is 5 % of the total hypertensive population. The predominant hemodynamic pattern appears to be increased systemic vascular resistance and plasma volume with normal or even low cardiac output. We must rule out pseudo-resistance before diagnosing true drug resistance. RH is a therapeutic challenge, and its management includes lifestyle interventions, avoiding nonadherence to treatment, avoiding inertia, appropriate use of antihypertensive drugs based on current evidence, especially long-acting diuretics, and the addition of mineralocorticoid receptor antagonists. RCTs to identify the most protective medical therapy in RH are needed. A series of drugs in different stages of investigation could significantly impact RH treatment in the future.
    MeSH term(s) Humans ; Hypertension/drug therapy ; Hypertension/diagnosis ; Antihypertensive Agents/therapeutic use ; Drug Resistance ; Blood Pressure Monitoring, Ambulatory ; Blood Pressure/drug effects ; Drug Therapy, Combination ; Calcium Channel Blockers/therapeutic use ; Diuretics/therapeutic use
    Chemical Substances Antihypertensive Agents ; Calcium Channel Blockers ; Diuretics
    Language English
    Publishing date 2024-01-15
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.12.026
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    Zs.A 2608: Show issues Location:
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  4. Article ; Online: CLINICAL AND EPIDEMIOLOGICAL EVALUATION OF COMPLICATIONS ASSOCIATED WITH GALLSTONES IN A TERTIARY HOSPITAL.

    Aguiar, Ridson Guilherme Parente de / Souza Júnior, Francisco Emanoel Albuquerque de / Rocha Júnior, José Leonardo Gomes / Pessoa, Francisco Sérgio Rangel de Paula / Silva, Leidiane Pinho da / Carmo, Gardênia Costa do

    Arquivos de gastroenterologia

    2022  Volume 59, Issue 3, Page(s) 352–357

    Abstract: ... complications.: Methods: We evaluated 158 patients admitted through discharge reports and medical records ... and the mean age of patients was 51.6 years. Men were significantly older than women (P=0.005). Most ... endoscopic retrograde cholangiopancreatography was necessary for 47.3% of patients without previous cholecystectomy and 81.4% of patients ...

    Abstract Background: Gallstones are the presence of bile clay in the gallbladder or bile ducts. The disease can be asymptomatic or symptomatic and can lead to complications and consequently a worse prognosis, such as acute cholecystitis, choledocholithiasis, cholangitis, and acute pancreatitis. The risk of complications increases after the first episode of biliary colic.
    Objective: A clinical-epidemiological evaluation of patients admitted to a gastroenterology ward of a tertiary care hospital with gallstone-related complications.
    Methods: We evaluated 158 patients admitted through discharge reports and medical records analysis from January 1, 2013, to February 24, 2021.
    Results: The female sex was predominant (76.6%), and the mean age of patients was 51.6 years. Men were significantly older than women (P=0.005). Most (57.6%) had some comorbidity, the most frequent being systemic arterial hypertension, diabetes mellitus, and obesity. The mean hospitalization time was 24 days, significantly longer in men (P=0.046) but without a direct relationship with age (P=0.414). The most frequent complication was choledocholithiasis, and 55.7% of patients without previous cholecystectomy had a report of biliary colic before admission, on average 1.5 years previously. A history of a prior cholecystectomy was present in 17.1% of those evaluated. Abdominal ultrasonography followed by magnetic resonance cholangiography was the most frequently performed exam for diagnostic definition. Regarding therapeutic measures, endoscopic retrograde cholangiopancreatography was necessary for 47.3% of patients without previous cholecystectomy and 81.4% of patients who have already had a cholecystectomy. Among patients not yet cholecystectomized, 84% underwent the procedure before discharge.
    Conclusion: The female patients were predominant. Men were significantly older than women and had more extended hospital stays. The most frequent complication was choledocholithiasis, and around half of the patients reported previous biliary colic. endoscopic retrograde cholangiopancreatography has been necessary for the majority of the patients.
    MeSH term(s) Acute Disease ; Choledocholithiasis/complications ; Choledocholithiasis/epidemiology ; Colic ; Female ; Gallstones/complications ; Gallstones/epidemiology ; Humans ; Male ; Middle Aged ; Pancreatitis/complications ; Pancreatitis/epidemiology ; Tertiary Care Centers
    Language English
    Publishing date 2022-09-12
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 137743-7
    ISSN 1678-4219 ; 0004-2803
    ISSN (online) 1678-4219
    ISSN 0004-2803
    DOI 10.1590/S0004-2803.202203000-64
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  5. Article: The evaluation of the effect of long-term antihypertensive drug usage on bone density with dental volumetric tomography.

    Guler, Ridvan / Agacayak, Kamil-Serkan

    Journal of clinical and experimental dentistry

    2024  Volume 16, Issue 2, Page(s) e172–e177

    Abstract: ... treatment for over 5 years, Group 3: 60 patients who received Beta Blocker treatment for over 5 years, Group ... 4: 60 patients who received ACE inhibitor treatment for over 5 years. Radiomorphometric measurements ... of Dentistry and underwent the Dental Volumetric Tomography (DVT) scan for any reason. The patients included ...

    Abstract Background: HT is a systemic disease that presents with persistent high blood pressure, which has become an important health problem due to its cause of serious complications and high prevalence in the community. Aim: This study aims to examine the bone mineral density (BMD) of male patients using different groups of antihypertensive drugs for long terms with dental volumetric tomography.
    Material and methods: The study was carried out using the data of patients who applied to the Dicle University Faculty of Dentistry and underwent the Dental Volumetric Tomography (DVT) scan for any reason. The patients included in the study were divided into 4 groups according to their antihypertensive use; Group 1: 60 patients who never used hypertensive medication before, Group 2: 60 patients who received Calcium Channel Blocker treatment for over 5 years, Group 3: 60 patients who received Beta Blocker treatment for over 5 years, Group 4: 60 patients who received ACE inhibitor treatment for over 5 years. Radiomorphometric measurements were made on the DVT data and the DVT-Mandibular Index Inferior, DVT-Cortical Index, Hounsfield Unit-Cortical and Hounsfield Unit-Spongios values were calculated. The Kruskal-Wallis test, the Mann Whitney test with Bonferroni correction, the One-Way ANOVA and Post-Hoc Tukey test were used in the study.
    Results: A significant increase in DVT-CI and a significant decrease in HU-CORTIKAL, HU-SPONGIOS and DVT-MII values were observed in the patients using Calcium Channel Blocker medication. These findings pointed to osteoporosis. In addition, no statistically significant difference in the use of antihypertensive drugs in the Beta Blocker and ACE Inhibitor groups compared to the Control Group were found.
    Conclusions: The long term use of Calcium Channel Blocker group antihypertensive drugs should be considered as a risk factor for osteoporosis in men.
    Language English
    Publishing date 2024-02-01
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2586647-3
    ISSN 1989-5488
    ISSN 1989-5488
    DOI 10.4317/jced.61240
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  6. Article ; Online: Evaluation of the European Society of Cardiology Risk Assessment Score in Incident Systemic Sclerosis-Associated Pulmonary Arterial Hypertension.

    Brown, Zoe / Hansen, Dylan / Stevens, Wendy / Ferdowsi, Nava / Ross, Laura / Quinlivan, Alannah / Sahhar, Joanne / Ngian, Gene-Siew / Apostolopoulos, Diane / Walker, Jennifer G / Proudman, Susanna / Teng, Gim Gee / Low, Andrea H L / Morrisroe, Kathleen / Nikpour, Mandana

    Arthritis care & research

    2024  

    Abstract: Objective: Patients with pulmonary arterial hypertension (PAH) may be stratified as low ... at baseline and follow-up (within 2 years) to a multinational incident cohort of systemic sclerosis-associated ... PAH. Treatment decisions for SSc-PAH should include risk assessments, aiming to achieve low-risk ...

    Abstract Objective: Patients with pulmonary arterial hypertension (PAH) may be stratified as low, intermediate, or high risk of 1-year mortality. In 2022, the European Society of Cardiology (ESC) updated and simplified its risk stratification tool, based on three variables: World Health Organization functional class, serum N-terminal pro-brain type natriuretic peptide and six-minute walk distance, applied at follow-up visits, intended to guide therapy over time.
    Methods: We applied the 2022 ESC risk assessment tool at baseline and follow-up (within 2 years) to a multinational incident cohort of systemic sclerosis-associated PAH (SSc-PAH). Kaplan-Meier curves, Cox hazards regression, and accelerated failure time models were used to evaluate survival by risk score.
    Results: At baseline (n = 260), the majority of SSc-PAH (72.2%) were graded as intermediate risk of death according to the 2022 tool. At follow-up, according to 2022 tool, half (55.5%) of the cohort were classified as low or intermediate-low risk. The 2022 risk model at follow-up was able to differentiate survival between risk strata. All three individual parameters (World Health Organization functional class, N-terminal pro-brain type natriuretic peptide, six-minute walk distance) were significantly associated with mortality at baseline and/or follow-up.
    Conclusion: The 2022 ESC risk assessment strategy applied at baseline and follow-up predicts survival in SSc-PAH. Treatment decisions for SSc-PAH should include risk assessments, aiming to achieve low-risk status according to the 2022 ESC guidelines.
    Language English
    Publishing date 2024-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645059-3
    ISSN 2151-4658 ; 0893-7524 ; 2151-464X
    ISSN (online) 2151-4658
    ISSN 0893-7524 ; 2151-464X
    DOI 10.1002/acr.25328
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  7. Article ; Online: Evaluation of photobiomodulation in the salivary production of patients with hyposalivation induced by antihypertensive drugs - A blind, randomized, controlled clinical trial.

    Varellis, Maria Lucia Zarvos / Bussadori, Sandra Kalil / Pavesi, Vanessa Christina Santos / Pereira, Benedito Jorge / Bezerra, Cícero Dayves Silva / Silva, Felipe Gonçalves / Castro, Gabriela Silva / Afonso, Rafaela Campos Teixeira / Barbosa Filho, Valdomiro Franscisco / Deana, Alessandro Melo

    Complementary therapies in clinical practice

    2024  Volume 56, Page(s) 101845

    Abstract: ... their salivary flow measured before and after the whole treatment.: Results: The intragroup analysis ... before and after treatment) shows a significant difference for both non-stimulated and stimulated salivary ... Background: Arterial hypertension is a systemic condition that affects about 35% of the world ...

    Abstract Background: Arterial hypertension is a systemic condition that affects about 35% of the world population. The drugs that are used for its control can produce hyposalivation. This work evaluated the effect of photobiomodulation on salivary flow rate, salivary pH, total protein concentration, and calcium concentration in individuals using antihypertensive medications.
    Material and methods: 41 subjects were randomly allocated in one of two groups: control (placebo) and photobiomodulation. The subjects had their salivary glands (20 sites) irradiated with a laser emitting at 808 nm, 4J/site once a week for 4 weeks and had their salivary flow measured before and after the whole treatment.
    Results: The intragroup analysis (before and after treatment) shows a significant difference for both non-stimulated and stimulated salivary flow in the photobiomodulation group (p = 0.0007 and p = 0.0001, respectively). Comparing the placebo with the photobiomodulation group, significant differences were found for both non-stimulated (p = 0.0441) and stimulated salivary flow (p = 0.0441) after the treatment. No significant differences were found in pH, total protein concentration, calcium concentration.
    Conclusion: Despite the usage of drugs that influence the nervous system and typically result in a reduction of saliva production, photobiomodulation demonstrated a remarkable ability to enhance saliva production by a significant 75%.
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2182834-9
    ISSN 1873-6947 ; 1744-3881
    ISSN (online) 1873-6947
    ISSN 1744-3881
    DOI 10.1016/j.ctcp.2024.101845
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    Zs.A 4912: Show issues Location:
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  8. Article ; Online: The evaluation of patients with optic disc edema: A retrospective study.

    Urfalioglu, Selma / Ozdemir, Gokhan / Guler, Mete / Duman, Gamze Gizem

    Northern clinics of Istanbul

    2021  Volume 8, Issue 3, Page(s) 280–285

    Abstract: ... findings, topical or systemic drugs, treatment methods, follow-up examination, and related data ... of the patients were obtained retrospectively.: Results: There were 77 female and 23 male patients in the study ... scleroderma in one, and pregnancy in two patients were detected. While 93 patients had no additional ocular ...

    Abstract Objective: Optic disc edema is among major problems that neuro-ophthalmology clinics encounter. We intended to analyze patients with optic disc edema in this article.
    Methods: Data related to the main complaint, associated systemic disease, visual acuity, characteristics of optic disc swelling, other ocular findings, topical or systemic drugs, treatment methods, follow-up examination, and related data of the patients were obtained retrospectively.
    Results: There were 77 female and 23 male patients in the study. Optic disc edema was detected bilaterally in 65 patients, unilaterally in 35 patients. The duration of the symptoms until the first application was 19.82±17.18 (0-90) days. There were no systemic disorders in 74 patients but diabetes mellitus in 11 patients, hypertension in four patients, coronary artery disease in three patients, urticaria in two patients, lymphoma in one, multiple sclerosis in one patient, mastoiditis in one patient, scleroderma in one, and pregnancy in two patients were detected. While 93 patients had no additional ocular findings, 2 had uveitis, 1 had corneal dystrophy, 1 had keratoconus, 1 had cataract, 1 had previous cataract surgery, and 1 had peripheral retinal degenerations. The major etiology of the optic disc edema was idiopathic intracranial hypertension, which was detected in 44 patients. In all these patients, bilateral optic disc edema was observed and 43 patients were given oral acetazolamide and one patient oral topiramate.
    Conclusion: The presence of optic nerve edema should be absolutely evaluated in patients presenting with symptoms of vision loss and increased intracranial pressure. The early diagnosis with fundoscopic examination may increase visual acuity in these patients.
    Language English
    Publishing date 2021-04-14
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 3031921-3
    ISSN 2536-4553 ; 2148-4902
    ISSN (online) 2536-4553
    ISSN 2148-4902
    DOI 10.14744/nci.2020.25483
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  9. Article ; Online: Evaluation of hypertension in systemic sclerosis and systemic lupus erythematosus overlap.

    Chew, Erin / Barnado, April / Ikizler, Talat Alp / Zent, Roy / Frech, Tracy

    Journal of scleroderma and related disorders

    2022  Volume 8, Issue 1, Page(s) 14–19

    Abstract: ... in systemic sclerosis and systemic lupus erythematosus overlap patients with systemic hypertension. Long-term assessment ... Patients with systemic sclerosis and systemic lupus erythematosus serologies present a unique ... challenge to the clinician when hypertension is detected in the outpatient setting. Treatment choices ...

    Abstract Patients with systemic sclerosis and systemic lupus erythematosus serologies present a unique challenge to the clinician when hypertension is detected in the outpatient setting. Treatment choices for non-renal crisis hypertension are different for systemic sclerosis versus systemic lupus erythematosus. Urgent laboratory studies and, in the presence of certain symptoms, imaging assessment are indicated in systemic sclerosis and systemic lupus erythematosus overlap patients with systemic hypertension. Long-term assessment of systemic hypertension may be enhanced by advances in non-contrast imaging that serve as valuable biomarkers for progressive vasculopathy. In this review, the diagnostic approach to systemic sclerosis and systemic lupus erythematosus overlap patients presenting with hypertension is discussed.
    Language English
    Publishing date 2022-09-14
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2397-1991
    ISSN (online) 2397-1991
    DOI 10.1177/23971983221122673
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  10. Article ; Online: Evaluation of the Demographic and Clinical Data of Psoriasis Patients

    Tugba Ozkok Akbulut / Filiz Topaloglu Demir / Ayse Nur Tufan / Nazli Caf / Baran Cayhan / Senay Agirgol / Zafer Turkoglu

    Haseki Tıp Bülteni, Vol 60, Iss 1, Pp 72-

    A Detailed Analysis of a Big Series

    2022  Volume 77

    Abstract: ... involvement. The follow-up and treatment of patients with psoriasis are important in terms of comorbidities. ... of the patients received only topical treatment, 80.1% underwent systemic treatment.Conclusions:The socio ... with the psoriasis area severity score index (PASI), comorbidities, and treatment of psoriasis in our follow-up ...

    Abstract Aim:Psoriasis is a chronic disease and requires follow-up settings to manage. The aim of the study is to evaluate the clinical characteristics, disease course, the factors associated with the psoriasis area severity score index (PASI), comorbidities, and treatment of psoriasis in our follow-up psoriasis outpatient clinic.Methods:Clinical data from patients who were followed in the University of Health Sciences Turkey, Haseki Training and Research Hospital psoriasis outpatient clinic between January 2015 and March 2021 were examined. The relationships between age, age of the disease onset, gender, joint involvement, and nail involvement were analyzed.Results:In total, 618 patients were included in our study (320 males and 298 females). The median age of the patients was 42 (1- 87) years. Family history was present in 25.9% of the patients. The most common clinical type was plaque psoriasis (80.2%). The median value of the PASI was 8.1. The disease course of the patients was progressive (46.4%), remission and exacerbations (37%), and regressive (16.7%). Nail involvement and joint involvement were observed in 58.1% and 24.2% of the patients, respectively. A significant correlation was found between PASI and joint involvement (p=0.009). Onycholysis (a type of nail involvement) was a positive predictive indicator for joint involvement (p=0.004). Comorbidity was present in 34.5% of the patients. Obesity, hypertension, diabetes mellitus, and dyslipidemia were the most common comorbidities. While 19.9% of the patients received only topical treatment, 80.1% underwent systemic treatment.Conclusions:The socio-demographic and enriched clinical data of psoriasis highlight the features that should be considered, especially in follow-up outpatient clinics. Patients showing an early onset of the disease should be investigated for severe involvement, such as the presence of onycholysis in the nail or evidence of joint involvement. The follow-up and treatment of patients with psoriasis are important in terms of comorbidities.
    Keywords psoriasis ; demographic ; plaque ; joint ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
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