Article ; Online: COVID-19 in celiac disease: a multicentric retrospective cohort study.
European review for medical and pharmacological sciences
2021 Volume 25, Issue 12, Page(s) 4400–4404
Abstract: ... cohort study evaluated 542 celiac patients, who answered a questionnaire concerning both the underlying disease ... Objective: Celiac disease (CD) is an autoimmune disorder, characterized by increased ... of CD on the risk of contracting this virus.: Patients and methods: This retrospective multicentric ...
| Abstract | Objective: Celiac disease (CD) is an autoimmune disorder, characterized by increased susceptibility to bacterial and viral infections. Therefore, the CD patients could be exposed to an increased risk of contracting SARS-CoV-2, a virus for which the WHO declared a pandemic status in March 2020. This study aims to investigate the incidence of SARS-CoV-2 infection in CD patients, to assess the impact of CD on the risk of contracting this virus. Patients and methods: This retrospective multicentric cohort study evaluated 542 celiac patients, who answered a questionnaire concerning both the underlying disease (adherence to the gluten-free diet, residual symptoms) and the possible SARS-CoV-2 infection (swab outcome, presence and characteristics of symptoms and type of treatment received), referring to the period between 20th January 2020 and 27th October 2020. Results: Five patients (0.92%) tested positive; of these, 2 were asymptomatic and 3 developed symptoms of COVID-19. The incidence of SARS-CoV-2 infection in CD patients was not significantly different from the general population. The ratio of positive/diagnostic swabs tends to be higher in CD patients than in the general population (IR: 0.15; 0.06; p=0.06), whereas the number of subjects who performed the swab in this group is significantly lower (IR: 0.06; 0.15; p<0.001). Conclusions: Although CD patients are more susceptible to infections, the incidence of SARS-CoV-2 infection in our sample was not significantly different from the general population. However, the positive/diagnostic swabs ratio seems to be higher, probably also due to the lower number of patients tested. |
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| MeSH term(s) | COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/therapy ; COVID-19 Testing/methods ; Celiac Disease/diagnosis ; Celiac Disease/epidemiology ; Celiac Disease/therapy ; Cohort Studies ; Diet, Gluten-Free/methods ; Humans ; Italy/epidemiology ; Retrospective Studies | |||||
| Language | English | |||||
| Publishing date | 2021-07-05 | |||||
| Publishing country | Italy | |||||
| Document type | Journal Article ; Multicenter Study ; Observational Study | |||||
| ZDB-ID | 605550-3 | |||||
| ISSN | 2284-0729 ; 1128-3602 ; 0392-291X | |||||
| ISSN (online) | 2284-0729 | |||||
| ISSN | 1128-3602 ; 0392-291X | |||||
| DOI | 10.26355/eurrev_202106_26150 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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